2019
DOI: 10.1002/ppul.24599
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Bronchiectasis in common variable immunodeficiency: A systematic review and meta‐analysis

Abstract: Background Common variable immunodeficiency (CVID) is the most prevalent symptomatic primary immunodeficiency disorder characterized by infectious and noninfectious complications. Bronchiectasis continues to be a common respiratory problem and therapeutic challenge in CVID. The aim of this study is to estimate the overall prevalence of bronchiectasis and its associated phenotype in patients with CVID. Methods A systematic literature search was performed in Web of Science, PubMed, and Scopus from the earliest a… Show more

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Cited by 35 publications
(26 citation statements)
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“…Patients in our follow-up cohort had a strikingly low prevalence of lymphopenia, which may underlie the milder course of immunodeficiency and possibly explain the absence of bronchiectasis. The finding of higher prevalence of low IgM levels in patients with subtle bronchiectasis changes is in concordance with reported correlations in patients with common variable immunodeficiency and bronchiectasis [16].…”
Section: Discussionsupporting
confidence: 91%
“…Patients in our follow-up cohort had a strikingly low prevalence of lymphopenia, which may underlie the milder course of immunodeficiency and possibly explain the absence of bronchiectasis. The finding of higher prevalence of low IgM levels in patients with subtle bronchiectasis changes is in concordance with reported correlations in patients with common variable immunodeficiency and bronchiectasis [16].…”
Section: Discussionsupporting
confidence: 91%
“…Therefore, the generalizability of the findings for the Manual Push Cohort in this study are limited to adults (aged ≥ 18 to 65 years) and normal-weight or obese individuals (BMI ≥ 19 kg/m 2 ). Finally, while the proportion of patients with bronchiectasis in this cohort (25%) compares well with the average proportion among patients with CVID in Europe (25%, range 0-66) [29], it is lower than the recently reported global average for patients with CVID (34%; 95% confidence interval: 30-38) [30]. Overall, the proportion of patients with bronchiectasis among patients with PID depends on many factors and shows great regional variability [31].…”
Section: Discussionsupporting
confidence: 45%
“…Bacterial sinopulmonary infections are often the presenting feature, most frequently caused by Haemophilus influenzae or Streptococcus pneumoniae (11,12). Recurrent and/ or severe lower respiratory tract infections, particularly pneumonia, lead to bronchiectasis with an overall estimated prevalence of 30-35% among CVID patients, which, when present in isolation, does not contribute to increased mortality (8,(11)(12)(13)(14). Interstitial lung disease (ILD), on the other hand, probably occurs due to immune dysregulation and/or viral infection rather than as a consequence of bacterial infection (7,15,16), and occurs alongside other diseaserelated complications, and shortens survival (7)(8)(9)16).…”
Section: Introductionmentioning
confidence: 99%