Bronchial Responsiveness to Ultrasonic Fog in Occupational Asthma Due to Toluene Diisocyanate

Moscato, Gianna; Dellabianca, Antonio; Corsico, Angelo; Biscaldi, G; Gherson, G; Vinci, G.

doi:10.1378/chest.104.4.1127

Cited by 11 publications

(7 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…sECP was measured with a double antibody radioimmunoassay (Pharmacia Diagnostics, Uppsala, Sweden). Spirometry was performed by means of a computerized, (21). The final datum obtained was the dose of MCH causing a 20% fall in FEV) (PD2oFEVlmchl.…”

Section: Methodsmentioning

confidence: 99%

Serum eosinophil cationic protein (sECP) in subjects with a history of asthma symptoms with or without rhinitis

Perfetti

Galdi

Brame

et al. 1999

Allergy

View full text Add to dashboard Cite

show abstract

Section: Methodsmentioning

confidence: 99%

Serum eosinophil cationic protein (sECP) in subjects with a history of asthma symptoms with or without rhinitis

Perfetti

Galdi

Brame

et al. 1999

Allergy

View full text Add to dashboard Cite

show abstract

“…Banks et al [1989] reported responsiveness to methacholine in 91% of isocyanate reactive subjects as compared with 43% of nonreactors. Moscato et al [1993] found that 78% of TDI reactors were AHR+ whereas 46% of nonreactors were AHR+. In this study, A PC20 FEV 1 < 8.0 mg/mL of methacholine was observed in 3.1% (2 of 64) of exposed workers.…”

Section: Discussionmentioning

confidence: 98%

“…The diagnosis of isocyanate-induced asthma has been made on the basis of a work history [Malo et al, 1991], methacholine challenge test [Moscato et al, 1991[Moscato et al, , 1993, TDI challenge test . Foam workers may still have high exposure to TDI, high prevalence of irritative symptoms, increased diurnal variation on peak expiratorȳ ow rate and evidence of chronic airway obstruction, particularly in those with > 10 years of exposure [Lee and Phoon, 1992].…”

Section: Discussionmentioning

confidence: 99%

Increase in airway hyperresponsiveness among workers exposed to methylene diphenyldiisocyanate compared to workers exposed to toluene diisocyanate at a petrochemical plant in Korea

et al. 2000

View full text Add to dashboard Cite

Background The purpose of this study was to investigate the prevalence of airway hyperresponsiveness induced by methylene diphenyldiisocyanate (MDI) and toluene diisocyanate (TDI) at a petrochemical industry complex in Korea. Methods Questionnaires, allergic skin test, and nonspecific airway hyperresponsiveness (AHR) were studied in 64 exposed workers and 27 control subjects. Questionnaires included questions about symptoms of cough, wheezing, chest tightness, dyspnea, rhinorrhea, sneezing, itching, stuffiness, tearing, urticaria, sore throat, and exacerbating time. Methacholine challenge tests were done. Bronchial responsiveness (BRindex) defined as log (% fall in FEV1)/log (last concentration of methacholine +10). Results Prevalence of AHR (PC20 FEV1 < 16.0 mg/mL of methacholine) was higher in MDI‐exposed workers than in TDI‐exposed workers [4/20 (20%) vs. 2/42 (4.7%), P < 0.05]. Twenty‐three workers (36%) of all subjects had respiratory symptoms. MDI‐exposed workers, in comparison with control subjects, had higher BRindex (0.73 ± 0.04 vs. 0.62 ± 0.02, P < 0.05). Workers exposed to TDI or MDI who had respiratory symptoms (n = 23), in comparison to workers exposed to TDI or MDI without respiratory symptoms (n = 41), had significantly higher BRindex (0.82 ± 0.06 vs. 0.60 ± 0.02, P < 0.05). FEV1 was significantly negatively correlated with BRindex (r = −0.253, P < 0.05). BRindex was not correlated with atopy, smoking status, and exposure duration. Conclusions These findings suggest that workers exposed to MDI are at a higher risk of asthma in comparison with TDI‐exposed workers and control subjects at a petrochemical plant in Korea. Am. J. Ind. Med. 37:663–667, 2000. © 2000 Wiley‐Liss, Inc.

show abstract

“…The MCH test was performed by means of a nebulizer (MEFAR, Brescia, Italy) connected to a dosimeter, as previously reported (21). The final datum obtained was the dose of MCH causing a 20% fall in FEV 1 (PD2oFEVlmch).…”

Section: Methodsmentioning

confidence: 99%

Serum eosinophil cationic protein (sECP) in subjects with a history of asthma symptoms with or without rhinitis

Perfetti

Galdi

Brame

et al. 1999

Allergy

View full text Add to dashboard Cite

Background Serum eosinophil cationic protein (sECP) has been proposed as a marker of disease activity in bronchial asthma. The study aimed to evaluate the role of sECP in screening asthmatics in a group of subjects with asthma and rhinitis symptoms, and the relationship between sECP and clinical and functional parameters of asthma. Methods A total of 185 subjects with asthma symptoms, 149 of them with rhinitis as well, underwent skin tests, spirometry, methacholine (MCH) test, blood sampling for eosinophil percentage (bEOS%) and sECP determination, and nasal secretions smear for eosinophil percentage (nEOS%) determination; PEF values, symptoms, and medication over a period of 4 weeks after sampling for sECP quantitation were recorded on a diary. Results A total of 99 (53%) subjects received a diagnosis of asthma (asthmatics), and 86 did not (nonasthmatics). In asthmatics, neither sECP nor bEOS% was significantly different from nonasthmatics. In asthmatics, sECP was higher in subjects with increased than in those with normal daily PEF variability (16.4, 6.8–24.4 vs 5.3, 3.9–8.4 μg/l; P<0.001). sECP was higher in moderate persistent asthma than in intermittent asthma (24.8, 10.6–53 vs 8.4, 5.6–14.1; P<0.05). In nonasthmatics (73 with a history of rhinitis), both sECP and bEOS% correlated with nEOS% (rho=0.35; P<0.01 and rho=0.53; P<0.001). Conclusions In adults with asthma symptoms with or without rhinitis, sECP did not distinguish asthmatics from nonasthmatics. In asthmatics, sECP was associated with PEF variability and symptom severity. In subjects with asthma and rhinitis, as well as in subjects with only rhinitis, sECP levels are possibly influenced by nasal inflammation.

show abstract

Bronchial Responsiveness to Ultrasonic Fog in Occupational Asthma Due to Toluene Diisocyanate

Cited by 11 publications

References 20 publications

Serum eosinophil cationic protein (sECP) in subjects with a history of asthma symptoms with or without rhinitis

Serum eosinophil cationic protein (sECP) in subjects with a history of asthma symptoms with or without rhinitis

Increase in airway hyperresponsiveness among workers exposed to methylene diphenyldiisocyanate compared to workers exposed to toluene diisocyanate at a petrochemical plant in Korea

Serum eosinophil cationic protein (sECP) in subjects with a history of asthma symptoms with or without rhinitis

Contact Info

Product

Resources

About