Bronchial Pleomorphic Adenoma Coexisting with Lung Cancer

Abstract

Pleomorphic adenoma usually occurs in the salivary glands but rarely in the trachea or bronchi. A 71-year-old man had abnormal shadows on a chest X-ray. Chest CT revealed one tumor in the right basal segment of the lung and another, in the left main bronchus. Bronchoscopic biopsy of the right tumor revealed well-differentiated squamous cell carcinoma. Right lower lobectomy and lymph node dissection were performed (pT2N0M0, stage IB). At the orifice of the left main bronchus, bronchoscopy identified a polypoid lesion nearly obstructing the airway. The lesion was resected with hot snare ablation. The histological examination revealed a mixture of epithelial and myxoid mesenchymal elements, characterized by ductal structures, squamous metaplasia, and cartilage tissue. The diagnosis was bronchial pleomorphic adenoma coexisting with squamous cell carcinoma of the lung.

Giant primary pleomorphic adenoma of the lung presenting as a post-traumatic pulmonary hematoma: a case report

“…Pleomorphic adenoma is the most common tumor of the major salivary glands, usually developing in the palate, tongue, nasopharynx or larynx. Its primary location in the lungs is extremely rare and it usually arises from the tracheal and bronchial seromucous glands [ 2 , 3 ]. Pulmonary adenomas usually include bronchial adenoma, alveolar adenoma, papillary adenoma and adenomas of the salivary gland while primary salivary-type lung cancers are rare tumors that include adenoid cystic carcinoma and mucoepidermoid carcinoma.…”

“…Pleomorphic adenoma constitutes about 1 % of all the cases of primary lung adenomas [ 2 ]. Considering age and gender there has not been any proven gender predominance and the patients’ age ranges from 8 to 74 [ 3 ], but it seems that they occur more common in younger patients. Clinically, pleomorphic adenoma of the lungs may present with dyspnea and hemoptysis or fever, weight loss, pleural effusion and shortness of breath depending on its location or frequently lacking any symptoms [ 4 ], as it occurred in our case.…”

Pleomorphic Adenoma of the Trachea: A Case Report

“…Pleomorphic adenoma is the most common tumor of the major salivary gland, rarely occurring in the lung and typically arising from the tracheal and bronchial seromucous glands 2,3. The exact definitive incidence has not been reported.…”

“…The exact definitive incidence has not been reported. The age range of patients diagnosed with pleomorphic adenoma is usually between 35 and 74 years, with no gender or age predominance,1,2 although a case has been reponted in an 8-year-old male 4. Almost half of these tumors were localized in the upper one-third of the trachea and 12% were localized in the lower one-third 5.…”

“…Because the tumor rarely occurs, standard management has not been established. In general, endoscopic resection or surgical segmental resection is selected as a treatment on the basis of tumor status and physician's preference 2,5. Endoscopic removal may be used when rapid respiratory symptom improvement or hemorrhage control is required.…”