Bronchial Mucoepidermoid Carcinoma

Gieraerts, Christopher; Proesmans, Marijke; Sauer, Kate; Smet, Maria-Helena; Breysem, Luc

doi:10.5334/jbr-btr.1215

Cited by 2 publications

(6 citation statements)

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“…MEC was first reported by Franz in 1959. 8 Although the disease generally occurs in the salivary glands, MEC in other organs such as the conjunctiva, 9 bronchus, 10 thymus, 11 and anal canal 12 has also been reported. MEC in other organs shares similar histological features with Sal-MEC.…”

Section: Discussionmentioning

confidence: 99%

Targeted-Gene Sequencing and Bioinformatics Analysis of Patients with Pancreatic Mucoepidermoid Carcinoma: A Case Report and Literature Review

Chen

Zhang

Huang

et al. 2021

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Background Primary pancreatic mucoepidermoid carcinoma (MEC) is an extremely rare malignant tumor with unclear etiology and pathogenesis. There are only eleven reported cases in English papers published from 1959 to 2020. MEC generally occurs in the salivary gland, but cases in the pancreas have also been reported. Although being considered as a low-grade indolent carcinoma, pancreatic MEC always invades the surrounding lymph node and metastasizes. The prognosis of pancreatic MEC is unsatisfactory. To date, the genetic alterations, mechanistic relationships among mutated genes and signaling pathways of pancreatic MEC are unclear. Patient and Methods This paper presents a case of rare primary pancreatic MEC in a 56-year-old male patient with liver metastasis. Radical surgery of distal pancreatectomy and radiofrequency ablation (RFA) of two liver metastatic lesions is conducted. Targeted-gene sequencing and bioinformatics analysis tools, including STRING, DAVID, cBioPortal, DGidb and Human Protein Atlas database (HPA), are used to clarify the biological functions and features of mutated genes in pancreatic MEC. Results Eight gene mutations (TP53, KRAS, ATR, FLI1, FLT4, MAGI2, RBM10, and TNFAIP3) were observed, and a tumor mutation burden (TMB) of 5.6 muts/Mb was calculated in the pancreatic MEC using targeted-gene sequencing. The patient subsequently underwent adjuvant chemotherapy and died three months after surgery. Gene–gene interaction network was constructed, which showed the significant interactions among eight mutated genes. In terms of the functions and pathways of eight gene mutations based on GO and KEGG, 20 tumor-related results are presented in this paper, Furthermore, the biological functions and features of pancreatic MEC are further compared with pancreatic ductal adenocarcinoma. Conclusion Pancreatic MEC requires early and effective treatment, and lymph node metastases and multiple organ metastases were unfavorable prognostic factors. Pancreatic MEC can be compared with other pancreatic cancers that have characteristic clinical phenotype, molecular alterations, functional information and enrichment pathway.

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Section: Discussionmentioning

confidence: 99%

Targeted-Gene Sequencing and Bioinformatics Analysis of Patients with Pancreatic Mucoepidermoid Carcinoma: A Case Report and Literature Review

Chen

Zhang

Huang

et al. 2021

OTT

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“…Bronchial mucoepidermoid carcinoma is an extremely rare disease in clinical practice. 1 It is a low-grade malignant epithelial tumour that originates from bronchial mucinous glands and consists of mucinous cells, squamous cells and intermediate cells. 3 Abundant mucus cells indicate a low degree of malignancy.…”

Section: Discussionmentioning

confidence: 99%

“…Bronchial mucoepidermoid carcinoma is rare in clinical practice, accounting for 0.1-0.2% of primary lung cancers. 1,2 This disease is even more rare in children.…”

Section: Introductionmentioning

confidence: 99%

“…2 Bronchial mucoepidermoid carcinoma is a low-grade malignant epithelial tumour that originates from bronchial mucinous glands and consists of mucinous cells, squamous cells and intermediate cells. 1,3 Unlike other malignant tumours, the younger the age of onset , the lower the grade of malignancy. 1 Surgical removal is the treatment choice for this disease.…”

Section: Introductionmentioning

confidence: 99%

“…1,3 Unlike other malignant tumours, the younger the age of onset , the lower the grade of malignancy. 1 Surgical removal is the treatment choice for this disease. 3 Clinically, most patients choose to undergo bronchoscopy to remove tumours but this method is only applicable for patients with tumours located in the main bronchus; and it cannot be removed, if located in the distal parts of the bronchus.…”

Section: Introductionmentioning

confidence: 99%

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Video-assisted Thoracoscopic Right Inferior Lobe Resection for Bronchial Mucoepidermoid Carcinoma in a 10-year Child

2021

J Coll Physicians Surg Pak

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Bronchial mucoepidermoid carcinoma is a rare disease in the field of thoracic surgery, and it is even more rarer in children. A 10-year Chinese child whose chief complaint was intermittent fever and cough for one year was referred to our hospital. Based on the imaging, pathology and immunohistochemistry findings, the patient was diagnosed with right inferior lobar bronchial mucoepidermoid carcinoma; and was treated with video-assisted thoracoscopic (VATS) right inferior lobe resection and had a good prognosis.

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Bronchial Mucoepidermoid Carcinoma

Cited by 2 publications

References 1 publication

Targeted-Gene Sequencing and Bioinformatics Analysis of Patients with Pancreatic Mucoepidermoid Carcinoma: A Case Report and Literature Review

Targeted-Gene Sequencing and Bioinformatics Analysis of Patients with Pancreatic Mucoepidermoid Carcinoma: A Case Report and Literature Review

Video-assisted Thoracoscopic Right Inferior Lobe Resection for Bronchial Mucoepidermoid Carcinoma in a 10-year Child

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