Bronchial lavage P<sup>16INK4A</sup>gene promoter methylation and lung cancer diagnosis: A meta-analysis

Yifan, D; Luo, Qun; Yingshuang, H; Xulin, L; Jian-Jun, W; Qian, Minfei; Yu, Yuman; Zhaoyang, Ruixue

doi:10.4103/0019-509x.172522

Indian J Cancer

2015

DOI: 10.4103/0019-509x.172522

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Bronchial lavage P^16INK4Agene promoter methylation and lung cancer diagnosis: A meta-analysis

D Yifan¹,

Qun Luo²,

H Yingshuang³

et al.

Abstract: Bronchial lavage P16INK4A promoter methylation can be a potential biomarker for diagnosis of lung cancer.

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2018

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P16^INK4a gene promoter methylation as a biomarker for the diagnosis of non‐small cell lung cancer: An updated meta‐analysis

et al. 2018

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BackgroundThis meta‐analysis was conducted to investigate the diagnostic performance of P16 INK4a gene promoter methylation as a biomarker of non‐small cell lung cancer (NSCLC).MethodsTwo reviewers independently searched the Web of Science, PubMed, Cochrane, Embase, China National Knowledge Infrastructure, and Chinese Biomedical Literature databases. Publications relevant to P16 INK4a gene promoter methylation in serum or bronchoalveolar fluid/sputum were screened and included in this meta‐analysis. Pooled diagnostic sensitivity, specificity, and symmetric receiver operating characteristic curve were calculated.ResultsTwenty‐six publications with 1768 lung cancer cases and 1323 controls were included. The pooled sensitivity, specificity, positive and negative likelihood ratios, and diagnostic odds ratio were 0.46 (95% confidence interval [CI] 0.43–0.48), 0.90 (95% CI 0.88–0.91), 6.33 (95% CI 3.89–10.30), 0.57 (95% CI 0.50–0.65) and 10.72 (95% CI 6.94–16.56), respectively, for P16 INK4a gene promoter methylation as a biomarker for the diagnosis of NSCLC. The area under the symmetric receiver operating characteristic curve was 0.75 with a standard error of 0.004. No publication bias was detected via line regression test (t = 0.95; P = 0.35) and Begg's funnel plot.Conclusion P16 INK4a gene promoter methylation detection in serum or bronchoalveolar fluid/sputum may be a potential biomarker for NSCLC diagnosis; however, the sensitivity was relatively low, which is not suitable for NSCLC screening.

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P16^INK4a gene promoter methylation as a biomarker for the diagnosis of non‐small cell lung cancer: An updated meta‐analysis

et al. 2018

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Bronchial lavage P^16INK4Agene promoter methylation and lung cancer diagnosis: A meta-analysis

Abstract: Bronchial lavage P16INK4A promoter methylation can be a potential biomarker for diagnosis of lung cancer.

Cited by 1 publication

References 0 publications

P16^INK4a gene promoter methylation as a biomarker for the diagnosis of non‐small cell lung cancer: An updated meta‐analysis

P16^INK4a gene promoter methylation as a biomarker for the diagnosis of non‐small cell lung cancer: An updated meta‐analysis

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Bronchial lavage P16INK4Agene promoter methylation and lung cancer diagnosis: A meta-analysis

Abstract: Bronchial lavage P16INK4A promoter methylation can be a potential biomarker for diagnosis of lung cancer.

Cited by 1 publication

References 0 publications

P16INK4a gene promoter methylation as a biomarker for the diagnosis of non‐small cell lung cancer: An updated meta‐analysis

P16INK4a gene promoter methylation as a biomarker for the diagnosis of non‐small cell lung cancer: An updated meta‐analysis

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Bronchial lavage P^16INK4Agene promoter methylation and lung cancer diagnosis: A meta-analysis

P16^INK4a gene promoter methylation as a biomarker for the diagnosis of non‐small cell lung cancer: An updated meta‐analysis

P16^INK4a gene promoter methylation as a biomarker for the diagnosis of non‐small cell lung cancer: An updated meta‐analysis