Bronchial Hyperreactivity in Allergic Upper Respiratory Disease

Robalo-Cordeiro, A. J. A.; Pinto‐Mendes, J; J, Carvalho; Gouveia, Carolina; Guimarães, Ricardo Morato Fiúza; Oliveira, L. A. C.

doi:10.1159/000411438

Cited by 1 publication

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“…The overall prevalence of airway hyperrepsonsiveness to methacholine in nonasthmatic patients with AR is generally considered to be about twice as high as that reported in the current study (16%). However, the reported frequencies have been quite variable, ranging from 10-15 to 75% [27,28]. A low percentage in the current study may reflect the asymptomatic state of the AR subjects at the time of entry.…”

Section: Discussionmentioning

confidence: 59%

Lower airway responses to rhinovirus 39 in healthy allergic and nonallergic subjects

Skoner

Doyle²,

Seroky³

et al. 1996

European Respiratory Journal

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L Lo ow we er r a ai ir rw wa ay y r re es sp po on ns se es s t to o r rh hi in no ov vi ir ru us s 3 39 9 i in n h he ea al lt th hy y a al ll le er rg gi ic c a an nd d n no on na al ll le er rg gi ic c s su ub bj je ec ct ts s ABSTRACT: Acute asthma is considered to be a complication of respiratory viral infections. This investigation assessed the effects of rhinovirus 39 (RV-39) infection both on the patency and responsiveness of the lower airways. Subjects with allergic rhinitis (AR; n=50) and without AR (non-AR; n=46) were intranasally inoculated with RV-39, and monitored for 8 days in an enclosed environment for changes in symptoms, signs, and airway physiology (pulmonary function, bronchial methacholine provocation). All subjects were infected postinoculation. Significant increases in nasal symptoms and secretion weights were observed, with peak effects on days 2-3. Cough was a relatively minor symptom and none of the subjects developed wheezing. Likewise, there were no significant changes in the measured functions of the lower airways. No allergy status effects were observed.Under these experimental conditions, rhinovirus 39 infection did not produce detectable alterations in lower airway function in healthy subjects with and without allergic rhinitis.

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Section: Discussionmentioning

confidence: 59%