2005
DOI: 10.1111/j.1399-3038.2005.00296.x
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Bronchial hyper‐responsiveness predicts the development of mild clinical asthma within 2 yr in school children with hay‐fever

Abstract: In children with mild asthma, symptoms are not always apparent. Therefore, results of tests play an important role for the diagnosis. First, to investigate whether children with bronchial hyper-responsiveness (BHR) but no symptoms of asthma in 1992 had developed clinical asthma at follow up in 1994. The second aim was to find out the diagnostic properties of tests for asthma/allergic inflammation, using either doctor diagnosed asthma (DDA), self-assessed symptoms of asthma or iso-capnic hyperventilation of col… Show more

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Cited by 22 publications
(11 citation statements)
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“…43 These findings may play an important role for the follow-up of children with allergic rhinitis without clinical asthma because asymptomatic bronchial hyperresponsiveness is described in association with subsequent development of asthma later in life. [44][45][46] Assessment of nasal eosinophilia does not seem to help the clinician identifying rhinitis children at particular risk of asthma because nasal eosinophilia was not a frequent finding in this age group, nor was nasal eosinophilia associated with any of the intermediary asthma endpoints.…”
Section: Discussionmentioning
confidence: 88%
“…43 These findings may play an important role for the follow-up of children with allergic rhinitis without clinical asthma because asymptomatic bronchial hyperresponsiveness is described in association with subsequent development of asthma later in life. [44][45][46] Assessment of nasal eosinophilia does not seem to help the clinician identifying rhinitis children at particular risk of asthma because nasal eosinophilia was not a frequent finding in this age group, nor was nasal eosinophilia associated with any of the intermediary asthma endpoints.…”
Section: Discussionmentioning
confidence: 88%
“…1 In children allergic rhinitis has also been shown to increase the prevalence of AHR, 22 and the presence of AHR with concomitant atopic manifestation increases the risk of asthma. 23,24 Rhinitis in preschool children is a risk factor for wheezing onset after the age of 5 years, but only when associated with atopic sensitization. Although this finding goes in line with the concept of united airways, 4 nonallergic rhinitis would also be expected to be associated with wheezing onset in this concept.…”
Section: Discussionmentioning
confidence: 99%
“…AR is often associated with allergic asthma, according to the concept of united airway disease [24], and up to 50% of patients with AR can present bronchial hyper-reactivity [25]. …”
Section: Prevention Of Asthma In Patients With Allergic Rhinitismentioning
confidence: 99%