Bronchial hyper‐responsiveness in preterm‐born subjects: A systematic review and meta‐analysis

Kotecha, Sailesh; Clemm, Hege; Halvorsen, Thomas

doi:10.1111/pai.12957

Cited by 32 publications

(27 citation statements)

References 44 publications

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“…Several studies have shown evidence of persistent abnormal lung function in later childhood for infants diagnosed with CLD. In previous systematic reviews, we have reported that preterm‐born subjects have deficits in FEV 1 , increased rates of bronchial hyper‐responsiveness, and single doses of bronchodilators appeared to improve FEV 1 . It has been reported that preterm‐born subjects have higher rates of wheezing and are often diagnosed with asthma.…”

Section: Introductionmentioning

confidence: 89%

Fractional exhaled nitric oxide in preterm‐born subjects: A systematic review and meta‐analysis

Course

Kotecha

2019

Pediatric Pulmonology

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Background Decreased lung function is common in preterm‐born survivors. Increased fractional exhaled nitric oxide (FeNO) appears to be a reliable test for eosinophillic airway inflammation especially in asthma. We, systematically, reviewed the literature to compare FeNO levels in preterm‐born children and adults who did or did not have chronic lung disease of prematurity (CLD) in infancy with term‐born controls. Methods We searched eight databases up to February 2018. Studies comparing FeNO levels in preterm‐born subjects (<37 weeks’ gestation) in childhood and adulthood with and without (CLD) with term‐born subjects were identified and extracted by two reviewers. Data were analysed using Review Manager v5.3. Results From 6042 article titles, 183 full articles were screened for inclusion. Nineteen studies met the inclusion criteria. Seventeen studies compared FeNO levels in preterm‐ and term‐born children and adults; 11 studies (preterm n = 640 and term n = 4005) were included in a meta‐analysis. The mean FeNO concentration difference between the preterm‐born and term‐born group was −0.74 (95% CI −1.88 to 0.41) ppb. For the six studies reporting data on CLD (preterm n = 204 and term n = 211) the mean difference for FeNO levels was −2.82 (95% CI −5.87 to 0.22) ppb between the preterm‐born CLD and term‐born groups. Conclusions Our data suggest that preterm born children with and without CLD have similar FeNO levels to term‐born children suggesting an alternative mechanism to eosinophilic inflammation for symptoms of wheezing and airway obstruction observed in preterm‐born subjects.

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Section: Introductionmentioning

confidence: 89%

Fractional exhaled nitric oxide in preterm‐born subjects: A systematic review and meta‐analysis

Course

Kotecha

2019

Pediatric Pulmonology

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“…The mechanisms of ASM contractility have been well studied in adults, 9,10 but are relatively less known in developing airways. Nonetheless, using isolated ASM cells from lungs of [18][19][20][21][22] week fetuses, we have demonstrate their suitability for studying regulation of [Ca 2+ ] i and proliferation, 11 showing that fASM cells express [Ca 2+ ] i regulatory proteins and respond to bronchoconstrictor agonists such as acetylcholine (ACh) and histamine with robust [Ca 2+ ] i responses. Using this model, we previously found that O 2 enhances fASM [Ca 2+ ] i 11 as well as cellular contractility, 12 and O 2induced increases in airway contractility have also been observed in neonatal mouse models of hyperoxia.…”

Section: Introductionmentioning

confidence: 89%

Hydrogen sulfide, oxygen, and calcium regulation in developing human airway smooth muscle

et al. 2020

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Preterm infants can develop airway hyperreactivity and impaired bronchodilation following supplemental O2 (hyperoxia) in early life, making it important to understand mechanisms of hyperoxia effects. Endogenous hydrogen sulfide (H2S) has anti‐inflammatory and vasodilatory effects with oxidative stress. There is little understanding of H2S signaling in developing airways. We hypothesized that the endogenous H2S system is detrimentally influenced by O2 and conversely H2S signaling pathways can be leveraged to attenuate deleterious effects of O2. Using human fetal airway smooth muscle (fASM) cells, we investigated baseline expression of endogenous H2S machinery, and effects of exogenous H2S donors NaHS and GYY4137 in the context of moderate hyperoxia, with intracellular calcium regulation as a readout of contractility. Biochemical pathways for endogenous H2S generation and catabolism are present in fASM, and are differentially sensitive to O2 toward overall reduction in H2S levels. H2S donors have downstream effects of reducing [Ca2+]i responses to bronchoconstrictor agonist via blunted plasma membrane Ca2+ influx: effects blocked by O2. However, such detrimental O2 effects are targetable by exogenous H2S donors such as NaHS and GYY4137. These data provide novel information regarding the potential for H2S to act as a bronchodilator in developing airways in the context of oxygen exposure.

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“…58 A comprehensive systematic review and meta-analysis has recently reviewed bronchial hyperresponsiveness (BHR) in preterm-born subjects. 59 Bronchial provocation tests to methacholine and exercise indicated that preterm-born individuals had greater BHR compared with term-born, particularly those with chronic lung disease.…”

Section: Pred Ic Ti On and Pre Venti On Of Allerg I C D Is E A S Ementioning

confidence: 99%

Highlights and recent developments in airway diseases in EAACI journals (2018)

Bousquet

Akdiş

Grattan

et al. 2019

Allergy

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The European Academy of Allergy and Clinical Immunology (EAACI) supports three journals: Allergy, Pediatric Allergy and Immunology, and Clinical and Translational Allergy. EAACI's major goals include supporting the promotion of health, in which the prevention of allergy and asthma plays a critical role, and disseminating the knowledge of allergic disease to all stakeholders. In 2018, the remarkable progress in the identification of basic mechanisms of allergic and respiratory diseases as well as the translation of these findings into clinical practice were observed. Last year's highlights include publication of EAACI guidelines for allergen immunotherapy, many EAACI Position Papers covering important aspects for the specialty, better understanding of molecular and cellular mechanisms, identification of biomarkers for disease prediction and progress monitoring, novel prevention and intervention studies, elucidation of mechanisms of multimorbidities, introduction of new drugs to the clinics, recently completed phase three clinical studies, and publication of a large number of allergen immunotherapy studies and meta‐analyses.

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Bronchial hyper‐responsiveness in preterm‐born subjects: A systematic review and meta‐analysis

Abstract: Preterm-born subjects especially those who had CLD had increased rates of BHR to direct (methacholine) and indirect (exercise) stimuli compared to term-born subjects suggesting subgroups might benefit from anti-inflammatory or bronchodilator therapies.

Cited by 32 publications

References 44 publications

Fractional exhaled nitric oxide in preterm‐born subjects: A systematic review and meta‐analysis

Fractional exhaled nitric oxide in preterm‐born subjects: A systematic review and meta‐analysis

Hydrogen sulfide, oxygen, and calcium regulation in developing human airway smooth muscle

Highlights and recent developments in airway diseases in EAACI journals (2018)

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