Bronchial Epithelial IgA Secretion Is Impaired in Asthma. Role of IL-4/IL-13

Ladjemi, Maha Zohra; Gras, Delphine; Dupasquier, Sébastien; Detry, Bruno; Lecocq, Marylène; Garulli, Céline; Fregimilicka, Chantal; Bouzin, Caroline; Gohy, Sophie; Chanez, Pascal; Pilette, Charles

doi:10.1164/rccm.201703-0561oc

Cited by 42 publications

(32 citation statements)

References 69 publications

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“…A COPD-like phenotype also develops in pIgR knockout mice upon exogenous bacterial challenge (185), and it has been shown in the past that COPD patients have an impaired pIgR expression (186) and reduced sIgA levels on the airway epithelium (187). Recently a similar phenomenon was reported for asthma (188) and rhinosinusitis (189). In the study of Ladjemi et al, asthmatics show a reduced immunostaining of pIgR in airway epithelia, with IL-4 and IL-13 being the suppressors of pIgR formation in the airway epithelium.…”

Section: Siga In Chronic Inflammation Of the Lungmentioning

confidence: 68%

“…In the study of Ladjemi et al, asthmatics show a reduced immunostaining of pIgR in airway epithelia, with IL-4 and IL-13 being the suppressors of pIgR formation in the airway epithelium. Notably, there were no significant differences in the pIgR gene expression rate among asthmatics and healthy individuals (188). Thus, a posttranslational event such as proteolytic degradation of pIgR in the epithelium may be responsible for the observed differences.…”

Section: Siga In Chronic Inflammation Of the Lungmentioning

confidence: 82%

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More Than Just a Barrier: The Immune Functions of the Airway Epithelium in Asthma Pathogenesis

et al. 2020

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Section: Siga In Chronic Inflammation Of the Lungmentioning

confidence: 68%

Section: Siga In Chronic Inflammation Of the Lungmentioning

confidence: 82%

More Than Just a Barrier: The Immune Functions of the Airway Epithelium in Asthma Pathogenesis

et al. 2020

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“…A dimer of two IgA monomers linked by J("joining") chain and secretory component (SC) composes SIgA (6), which is transported across airway epithelial cells via the polymeric immunoglobulin receptor (pIgR). After transportion to the mucosal surface, pIgR is cleaved and SC remains attached to form SIgA (7). SC is an extracellular component of pIgR, which plays a role in stabilizing the structure of SIgA in the process of transportion (8).…”

Section: Introductionmentioning

confidence: 99%

Effect of hydrogen inhalation on IL-40 and SIgA in a Rat Model of Pulmonary Mucosal Immunity

Sun

Zhu

et al. 2020

Preprint

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AbstractBackgroundRecently, some researchers have reported that PIgR expression is down-regulated in Chronic Obstructive Pulmonary Disease (COPD) and SIgA deficiency correlates with severity of airflow obstruction. What’ s more, some studies have demonstrated that 2 percent of hydrogen or hydrogen water is effective in treating and preventing various diseases.ObjectivesThe aim of this study was to observe the effect of hydrogen on the expression of SIgA, PIgR, IL-4, IL-5, TGF-β1 and IL-40 in lung tissue of COPD rats, to study the relationship between lung pathology parameter and SIgA, PIgR, therefore we can understand the effect of hydrogen on the development of COPD by changing SIgA expression of airway mucosal in COPD rats.MethodsA rat model of COPD was established by cigarette smoke exposure, and different concentrations of hydrogen were inhaled as intervention measures. After 4 months of cigarette smoke exposure, pathologic changes and airway wall remodeling of the lung were assessed by optical microscope. The protein expressions of SIgA, PIgR, IL-4, IL-5, TGF-β1 as well as IL-40 in the lung tissues were observed by immunohistochemistry or Western blot. The correlation between lung pathology parameter and the expression of SIgA, PIgR was analyzed. The correlation between SIgA and the expression of IL-4, IL-5, TGF-β1 and IL-40 was analyzed.ResultsThe results showed that hydrogen inhalation significantly ameliorated lung pathology and airway wall remodeling, increased the protein expression of SIgA, PIgR, IL-4, IL-5, and IL-40, and reduced the protein expression of TGF-β1.ConclusionsInhalation of 22% and 41.6% hydrogen showed a better effect than inhalation of 2% hydrogen. Hydrogen inhalation can significantly improve the expression of SIgA on the mucosal surface of COPD rats, which may be one of the mechanisms which hydrogen works on COPD pathogenesis.

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“…Several factors are suspected to contribute to the increased frequency of respiratory infections/exacerbation in these patients: (i) alteration of the host immune response to respiratory pathogens through modulation of cytokines/chemokine secretion [ 30 ] and decreased production and/or activity of epithelial HDPs [ 31 ]; (ii) epithelial injury induced by chronic inflammation or direct exposure to cigarette smoke exposure, resulting in, e.g., decreased mucosal integrity and barrier activity [ 32 ]; (iii) airway epithelium remodelling resulting in impaired ciliary activity and modification of mucus secretion, composition and physical properties leading to altered mucociliary transport and deficient pathogen clearance [ 33 , 34 , 35 , 36 , 37 , 38 ]; (iv) changes in airway epithelial cell composition negatively affecting the presence of host defence proteins and peptides (HDPs) and leading to locally impaired antimicrobial defences [ 39 ]; (v) IgA/IgM transport across the airway epithelium into mucosal secretions may be impaired as a result of changes in pIgR expression in these diseases [ 40 , 41 ]. These processes and how they are affected in chronic inflammatory lung diseases are summarised in Figure 1 .…”

Section: Introductionmentioning

confidence: 99%

Contribution of Host Defence Proteins and Peptides to Host-Microbiota Interactions in Chronic Inflammatory Lung Diseases

et al. 2018

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The respiratory tract harbours a variety of microorganisms, collectively called the respiratory microbiota. Over the past few years, alterations in respiratory and gut microbiota composition have been associated with chronic inflammatory diseases of the lungs. How these changes influence disease development and progression is an active field of investigation. Identifying and understanding host-microbiota interactions and factors contributing to these interactions could promote the development of novel therapeutic strategies aimed at restoring host-microbiota homeostasis. In this review, we discuss recent literature on host-microbiota interactions in the respiratory tract, with a specific focus on the influence of endogenous host defence peptides and proteins (HDPs) on the composition of microbiota populations in vivo and explore possible HDPs-related therapeutic approaches targeting microbiota dysbiosis in chronic inflammatory lung diseases.

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Bronchial Epithelial IgA Secretion Is Impaired in Asthma. Role of IL-4/IL-13

Abstract: This study shows impaired bronchial epithelial pIgR expression in asthma, presumably affecting secretory IgA-mediated frontline defense as a result of type 2 immune activation of the transforming growth factor pathway.

Cited by 42 publications

References 69 publications

More Than Just a Barrier: The Immune Functions of the Airway Epithelium in Asthma Pathogenesis

More Than Just a Barrier: The Immune Functions of the Airway Epithelium in Asthma Pathogenesis

Effect of hydrogen inhalation on IL-40 and SIgA in a Rat Model of Pulmonary Mucosal Immunity

Contribution of Host Defence Proteins and Peptides to Host-Microbiota Interactions in Chronic Inflammatory Lung Diseases

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