Bronchial epithelial changes associated with small cell carcinoma of the lung

Yoneda, K; Boucher, Leslie D.

doi:10.1016/0046-8177(93)90213-z

Cited by 9 publications

(5 citation statements)

References 13 publications

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“…In 1953, Slaughter et al (1953 proposed the "field cancerization" concept for oral cancer based on the observation in resected oral tumor samples of separate foci of in situ cancer, isolated islands of invasive squamous-cell carcinoma and pre-cancerous lesions surrounding the oral tumor, which suggested multicentric origin. Similar histologic changes have been described in the bronchial epithelium of patients with lung cancer (Auerbach et al, 1957;Yoneda and Boucher, 1993). However, in another tobacco-associated malignancy, bladder cancer, X-chromosome inactivation and genetic analyses have shown that multifocal bladder cancers are clonal (Habuchi et al, 1993;Sidransky et al, 1992), presumably arising from the progeny of a pre-invasive cell spread by propagation through the bladder epithelium (Sidransky et al, 1992) or by intraluminal seeding (Habuchi et al, 1993).…”

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confidence: 99%

TP53 and RAS mutations in metachronous tumors from patients with cancer of the upper aerodigestive tract

Yang

Linnoila

Conrad³

et al. 1995

Intl Journal of Cancer

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Patients who initially develop an upper aerodigestive tract cancer have an increased risk of second primary cancers. We examined TP53 and RAS mutations and p53 protein in 21 tumors from 10 patients with upper aerodigestive tract cancer who developed a metachronous tumor, to assess the genetic changes that occur in multiple primary tumors from the same individual. Thirteen of 21 (62%) tumors were found to have mis-sense mutations of either TP53 or RAS. Six tumors had TP53 mutations in codons 5 to 8 and 10 tumors from 7 patients had mutations of codons 12 or 13 of K-RAS. Only one patient had concordance of a mutation in 2 tumors; this mutation occurred in K-RAS and was accompanied by discordance of TP53 mutation. Three patients had tumors discordant for both TP53 and RAS mutations. Smoking-related tumors had TP53 and RAS mutations which were transversions in 11 (9 G:C to T:A and 2 G:C to C:G) and transitions in 3 (2 G:C to A:T and 1 A:T to G:C). Tumors not associated with smoking contained only transitions (both G:C to A:T). p53 protein was detected by immunohistochemistry in 7 of 13 (54%) tumors and was concordant in the multiple tumors of 3 patients. Three of the 7 tumors staining for p53 also had TP53 mutations. Thus, genetic alterations are discordant in multiple primary cancers and the pattern of mutations is similar to that found in patients with a single primary tumor, supporting the concept that these cancers arise independently.

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confidence: 99%

TP53 and RAS mutations in metachronous tumors from patients with cancer of the upper aerodigestive tract

Yang

Linnoila

Conrad³

et al. 1995

Intl Journal of Cancer

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“…It has been well recognized that lung carcinoma can provoke reactive atypia in bronchial epithelium that is adjacent to or undermined by carcinoma. 25,26 In one patient, from whom histology of an adenocarcinoma was available, we found a normal FISH pattern in the atypical cells in the BAL but marked chromosomal aberrations in the histologic tumor specimen. In another patient, atypical squamous cells in the sputum were followed by a diagnosis of SCLC.…”

Section: Discussionmentioning

confidence: 96%

Multitarget Fluorescence In Situ Hybridization Elucidates Equivocal Lung Cytology

Savic¹,

Glatz²,

Schoenegg

et al. 2006

Chest

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“…1(p30) The medical literature contains several reports of microscopic findings in the bronchial epithelium in patients with SCLC. [2][3][4][5][6] In 1957, Ryan et al 2 reported on their examination of macroscopically normal epithelium obtained from the proximal portion of a bronchus in 38 pneumonectomy specimens with SCLC. Squamous metaplasia was observed in 71%; there were no examples of carcinoma in situ.…”

Section: Discussionmentioning

confidence: 99%

“…In 1993, Yoneda and Boucher 4 reported the results of their study of bronchial epithelial changes associated with SCLC derived from examination of bronchoscopic biopsy specimens of SCLC from 128 cases. A total of 37% of the cases showed normal bronchial epithelium, 47% showed benign squamous metaplasia, 9% atypical squamous metaplasia, and 5% SCC in situ.…”

Section: Discussionmentioning

confidence: 99%

Small Cell Lung Carcinoma With Marked Bronchial Epithelial Involvement

Rosen

Durie

2011

Int J Surg Pathol

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Marked involvement of bronchial epithelium by malignant cells with a neuroendocrine immunophenotype was observed in a pulmonary lobectomy specimen containing combined small cell lung carcinoma (SCLC). Review of the medical literature reveals scant information on malignant neuroendocrine cells in bronchial epithelium accompanying SCLC and no documentation of an SCLC precursor. We discuss the possibility that the intraepithelial neoplastic lesion that we have described may be a primary lesion and possibly a precursor of SCLC and the alternative possibility that it represents invasion by underlying invasive SCLC. The need for further comprehensive study of the morphology and immunophenotype of bronchial mucosal abnormalities accompanying SCLC utilizing lung resection specimens is emphasized.

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Bronchial epithelial changes associated with small cell carcinoma of the lung

Cited by 9 publications

References 13 publications

TP53 and RAS mutations in metachronous tumors from patients with cancer of the upper aerodigestive tract

TP53 and RAS mutations in metachronous tumors from patients with cancer of the upper aerodigestive tract

Multitarget Fluorescence In Situ Hybridization Elucidates Equivocal Lung Cytology

Small Cell Lung Carcinoma With Marked Bronchial Epithelial Involvement

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