Bronchial epithelial cells release inflammatory markers linked to airway inflammation and remodeling in response to TLR5 ligand flagellin

Losol, Purevsuren; Ji, Mi-Hong; Kim, Jin Hee; Choi, Jun-Pyo; Yun, Jeong-Eun; Seo, Jang-Ho; Kim, Byung-Keun; Chang, Yoon-Seok; Kim, Sae‐Hoon

doi:10.1016/j.waojou.2023.100786

Cited by 2 publications

(1 citation statement)

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“…125 The airways of asthmatic patients have an increased relative abundance of Proteobacteria (Haemophilus, Neisseria, and Moraxella genera), 126 which might potentiate inflammation through the expression of immunogenic compounds, such as lipopolysaccharides or flagellin. 127,128 However, in the complete absence of microbes, asthma is also exacerbated as indicated by enhanced type 2 immunity of germ-free mice, which can be restored by microbiota re-colonization. 129 These observations point to the importance of a balanced microbiota composition and microbial metabolites in maintaining lung homeostasis (Figure 2).…”

Section: Asthmamentioning

confidence: 99%

A cross talk between microbial metabolites and host immunity: Its relevance for allergic diseases

Losol,

Wolska,

Wypych

et al. 2024

Clinical & Translational All

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BackgroundAllergic diseases, including respiratory and food allergies, as well as allergic skin conditions have surged in prevalence in recent decades. In allergic diseases, the gut microbiome is dysbiotic, with reduced diversity of beneficial bacteria and increased abundance of potential pathogens. Research findings suggest that the microbiome, which is highly influenced by environmental and dietary factors, plays a central role in the development, progression, and severity of allergic diseases. The microbiome generates metabolites, which can regulate many of the host’s cellular metabolic processes and host immune responses.Aims and MethodsOur goal is to provide a narrative and comprehensive literature review of the mechanisms through which microbial metabolites regulate host immune function and immune metabolism both in homeostasis and in the context of allergic diseases.Results and DiscussionWe describe key microbial metabolites such as short‐chain fatty acids, amino acids, bile acids and polyamines, elucidating their mechanisms of action, cellular targets and their roles in regulating metabolism within innate and adaptive immune cells. Furthermore, we characterize the role of bacterial metabolites in the pathogenesis of allergic diseases including allergic asthma, atopic dermatitis and food allergy.ConclusionFuture research efforts should focus on investigating the physiological functions of microbiota‐derived metabolites to help develop new diagnostic and therapeutic interventions for allergic diseases.

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