Bronchial epithelial cell B7-1 and B7-2 mRNA expression after lung transplantation: a role in allograft rejection?

Elssner, Andreas; Jaumann, F.; Wp, Wolf; Schwaiblmair, Martin; Behr, Jürgen; Fürst, H.; Reichenspurner, Hermann; Briegel, Josef; Niedermeyer, J; Vogelmeier, Claus

doi:10.1183/09031936.02.00268102

Cited by 20 publications

(14 citation statements)

References 15 publications

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“…Compared with other grafts such as skin and hepatocytes, lungs are rich in nonhematopoietic cells such as vascular endothelial cells and airway epithelial cells. Interestingly, bronchial epithelial cells, a nonhematopoietic cell population unique to lung grafts, have been shown to express B7 after lung transplantation in humans (57). Thus, attenuated rejection after CD28/B7 blockade in CD4-depleted lung transplant recipients may at least in part be due to inhibition of CD8 ϩ T cell activation by nonhematopoietic allograft cells.…”

Section: Discussionmentioning

confidence: 99%

CD4+ T Lymphocytes Are Not Necessary for the Acute Rejection of Vascularized Mouse Lung Transplants

Gelman¹,

Okazaki²,

Lai³

et al. 2008

The Journal of Immunology

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Acute rejection continues to present a major obstacle to successful lung transplantation. Although CD4+ T lymphocytes are critical for the rejection of some solid organ grafts, the role of CD4+ T cells in the rejection of lung allografts is largely unknown. In this study, we demonstrate in a novel model of orthotopic vascularized mouse lung transplantation that acute rejection of lung allografts is independent of CD4+ T cell-mediated allorecognition pathways. CD4+ T cell-independent rejection occurs in the absence of donor-derived graft-resident hematopoietic APCs. Furthermore, blockade of the CD28/B7 costimulatory pathways attenuates acute lung allograft rejection in the absence of CD4+ T cells, but does not delay acute rejection when CD4+ T cells are present. Our results provide new mechanistic insight into the acute rejection of lung allografts and highlight the importance of identifying differences in pathways that regulate the rejection of various organs.

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Section: Discussionmentioning

confidence: 99%

CD4+ T Lymphocytes Are Not Necessary for the Acute Rejection of Vascularized Mouse Lung Transplants

Gelman¹,

Okazaki²,

Lai³

et al. 2008

The Journal of Immunology

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“…Respiratory tract epithelial cells are well known to be directly involved in tissue rejection following lung transplant (5,27), indicating their participation in T cell immune regulatory processes involving the airway mucosa. The broad range of immune molecule genes expressed constitutively by HNE cells suggests the possibility of a role for cells of upper and lower airways in other immunity-associated inflammatory processes that entail the activation of CD4ϩ memory T cells.…”

Section: Discussionmentioning

confidence: 99%

Expression of genes for B7-H3 and other T cell ligands by nasal epithelial cells during differentiation and activation

Saatian¹,

Yu²,

Lane³

et al. 2004

American Journal of Physiology-Lung Cellular and Molecular Phys

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Epithelial cells of the human respiratory tract express human leukocyte antigen (HLA) and the costimulatory molecules B7-1 and B7-2. Little is known, however, about the constitutive expression of genes encoding for the more recently identified members of the B7 homolog family of costimulatory molecules or about the influence of cellular differentiation and cytokines on their activity or on that of HLA or B7-1 and B7-2. Human nasal epithelial (HNE) cells were grown at the air-liquid interface (ALI) for 2 or 21 days to model in vivo conditions. Expression of genes for HLA-B and HLA-DR1 increased during mucociliary differentiation during this period and became more similar to HNE cells obtained fresh by brush biopsy from nasal turbinates. Gene transcripts for B7-H3 and B7-H2 were abundantly expressed in cells cultured at the ALI, but neither their activities nor that of B7-2 was significantly altered during differentiation. IFN-gamma and TNF-alpha upregulated mRNA encoding for both HLA molecules, but not for the B7 molecules. This study describes, for the first time, the expression of B7-H3 and B7-H2 by HNE cells and thus expands the range of potential costimulatory signals through which these cells may interact with activated mucosal T lymphocytes. In addition, the results suggest that the extent of mucociliary differentiation of cultured cells may influence this capability

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“…In patients with BOS, bronchial epithelial cells overexpress the Ki-67 antigen [30] (which is a proliferation marker) and co-stimulatory B7 molecules [95]. As a result of epithelium destruction, there is a decline in Clara cell function and protein production with decreased concentration in BAL fluid [96].…”

Section: Human Studiesmentioning

confidence: 99%

Post-transplant bronchiolitis obliterans

Boehler

Estenne²

2003

European Respiratory Journal

177

105

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Over the last decade, improvements in surgical techniques, lung preservation, immunosuppression, and management of ischaemia/reperfusion injury and infections have made intermediate-term survival after lung transplantation an achievable goal. However, chronic allograft dysfunction in the form of bronchiolitis obliterans remains a major hurdle that threatens both the quality of life and long-term survival of the recipients. It affects up to 50-60% of patients who survive 5 yrs after surgery, and it accounts for w30% of all deaths occurring after the third postoperative year.This article discusses the alloimmune-dependent and -independent risk factors for bronchiolitis obliterans, the current understanding of the pathogenesis of bronchiolitis obliterans based on results of animal and human studies, the clinical staging of the complication, strategies that may contribute to the prevention and/or early detection of bronchiolitis obliterans, and suggestions for future research.

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Bronchial epithelial cell B7-1 and B7-2 mRNA expression after lung transplantation: a role in allograft rejection?

Cited by 20 publications

References 15 publications

CD4+ T Lymphocytes Are Not Necessary for the Acute Rejection of Vascularized Mouse Lung Transplants

CD4+ T Lymphocytes Are Not Necessary for the Acute Rejection of Vascularized Mouse Lung Transplants

Expression of genes for B7-H3 and other T cell ligands by nasal epithelial cells during differentiation and activation

Post-transplant bronchiolitis obliterans

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