Bronchial circulation in high altitudes

Zapata-Ortiz, V.; Mata, Ramiro Castro de la; Fernández, Erika; A, Geu; Batalla, L

doi:10.1152/ajplegacy.1967.212.6.1464

Cited by 6 publications

(4 citation statements)

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“…Histamine causes vasoconstriction of the pulmonary circulation and vasodilation of the systemic vascular bed 6. In the bronchial circulation, histamine inhalation causes an increase in blood flow which is mediated via H 2 -receptors 7…”

Section: Physiology Of the Bronchial Circulationmentioning

confidence: 99%

The airway vasculature: recent advances and clinical implications

Paredi¹,

Barnes

2009

Thorax

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It is increasingly recognised that the airway circulation plays an important role in airway diseases, either through a change in blood flow or through microvascular leakage. Most of the information available regarding the anatomy and physiology of bronchial blood flow and its regulation has necessarily derived from animal studies. However, there have recently been important advances in understanding airway blood flow in airway disease in humans through the development of non-invasive methods and in the quantification of microvascular leakage using plasma markers. These studies have shown that bronchial blood flow is increased in patients with asthma but not in those with chronic obstructive pulmonary disease, confirming previous pathology investigations. Changes in bronchial blood flow may in part reflect the generation of new vascular vessels, a process known as ''angiogenesis'' which is caused by airway inflammation. Angiogenesis and the resulting plasma leak affect airway physiology, drug clearance and its bioavailability. This review discusses the anatomy, physiology and regulation of bronchial blood flow in the normal and diseased lung, In addition, it analyses the effect of current medical treatment and discusses the potential use of new antiangiogenesis medications. The development of noninvasive assessment of bronchial blood flow and the study of angiogenesis have provided a tool to investigate airway physiology in vivo; these advances will contribute to a better understanding of inflammatory airway diseases as well as the implication of these findings to management.

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Section: Physiology Of the Bronchial Circulationmentioning

confidence: 99%

The airway vasculature: recent advances and clinical implications

Paredi¹,

Barnes

2009

Thorax

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“…Systemic arterial pressure has been shown to be a direct determinant of both total 48 and anastomotic bronchial blood flow. 49,50 In sheep a reduction in Q br was observed when systemic perfusion pressures decreased, with cessation occurring at upstream pressures of between 25 and 60 mmHg.…”

Section: Vascular and Airway Pressuresmentioning

confidence: 99%

The bronchial circulation—worth a closer look: A review of the relationship between the bronchial vasculature and airway inflammation

McCullagh

Rosenthal

Wanner

et al. 2009

Pediatric Pulmonology

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Until recently, the bronchial circulation has been relatively ignored in the research and clinical arenas, perhaps because of its small volume and seeming dispensability relative to the pulmonary circulation. Although the bronchial circulation only receives around 1% of the cardiac output in health, it serves functions that are critical to maintaining airway and lung function. The bronchial circulation also plays an important role in many lung and airway diseases; through its ability to increase in size, the bronchial circulation is able to provide lung parenchymal perfusion when the pulmonary circulation is compromised, and more recently the role of the bronchial circulation in the pathogenesis of inflammatory airway disease has been explored. Due to the anatomic variability and small volume of the bronchial circulation, much of the research to date has necessitated the use of animal models and invasive procedures. More recently, non-invasive techniques for measuring bronchial blood flow in the mucosal microvascular network have been developed and offer a new avenue for the study of this circulation in humans. In conjunction with molecular research, measurement of airway blood flow (Q(aw)) may help elucidate the role of the bronchial circulation in inflammatory airway disease and become a useful tool for monitoring therapy.

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“…Excised strips of bronchial and pulmonary artery were found to contract in a dose-dependent fashion when ex posed to histamine, prostaglandin E2 and F2-alpha, and bovine slow-reacting sub stance of anaphylaxis (SRS-A); the thresh old concentrations for prostaglandins and SRS-A were higher for the bronchial ar tery, whereas histamine was approxi mately equipotent [3]. Histamine has also been shown to increase 0br in dogs [9] and sheep [41].…”

Section: Bronchial Blood Flowmentioning

confidence: 99%

Bronchial Circulation in Asthma

Baier¹,

Long²,

Wanner³

1985

Respiration

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Whereas the anatomical changes of the bronchial circulation in response to a wide variety of congenital and acquired cardiopulmonary diseases have been well described, little is known about its functional response. There is growing evidence that the bronchial circulation plays a major role in the pathophysiology of hyperreactive airway disease. The bronchial vascular system appears to be involved in mediator transport to and from target tissues in the airway wall, in the development of airway wall edema which may contribute to airflow obstruction, and in heat and water exchange in the tracheobronchial tree. Although our current understanding of these functions is rather sketchy, enough is known to outline the contributions of the bronchial, i.e. the systemic circulation to the mechanisms of bronchial asthma.

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Bronchial circulation in high altitudes

Cited by 6 publications

References 0 publications

The airway vasculature: recent advances and clinical implications

The airway vasculature: recent advances and clinical implications

The bronchial circulation—worth a closer look: A review of the relationship between the bronchial vasculature and airway inflammation

Bronchial Circulation in Asthma

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