Bronchial carcinoid with massive ossification: A case report and review of literature

Abstract

Case Report AbstractWe report a case of a 47-year-old male with unexplained fatigue, shortness of breath, fever, chronic cough, and weight loss of over 12 pounds over a 3 months period. Chest x-ray revealed complete opacification of the right hemithorax with collapse of the right middle and lower lung lobes and midline shift towards the right. A CT scan with contrast showed a 6 cm mass arising from the right mainstem bronchus that was completely occluding the lumen, causing right lung atelectasis. Histopathologic examination of the tumor revealed an atypical carcinoid tumor with massive ossification. This is a case report and review of the literature of the rare bronchial carcinoid demonstrating bone formation.

Pulmonary ossifying carcinoid – MEN in a male?

“…So far, there have been only six such surgically excised cases have been reported [ Table 2 ]. [ 1 3 4 5 6 7 ] Atypical carcinoid was present in one other patient 6 ; metastases were noted in two cases. [ 5 6 ] The pathogenesis is explained based on “osteomimicry” due to the release of osteopontin and osteocalcin.…”

“…[ 1 3 4 5 6 7 ] Atypical carcinoid was present in one other patient 6 ; metastases were noted in two cases. [ 5 6 ] The pathogenesis is explained based on “osteomimicry” due to the release of osteopontin and osteocalcin. [ 5 ] In our case, osteopontin immunohistochemistry was negative; staining for osteocalcin was not performed.…”