Bronchial Carcinoid Tumors in Pediatric Patients

Wang, Linda T.; Wilkins, Earle W.; Bode, Hans H.

doi:10.1378/chest.103.5.1426

Cited by 92 publications

(54 citation statements)

References 13 publications

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“…More recent surgical techniques, which involve sequential anastomosis of each donor lung to the distal main bronchi on each side, result in much less airway ischaemic damage even in the absence of bronchial artery revascularization [27]. Finally, bronchial carcinoid tumours are derived from Kulchitsky cells which are located in the epithelial component of the bronchial mucosa [28]. While the peritracheal and adventitial tissues are supplied predominantly by the pulmonary circulation, the bronchial mucosa derives its blood supply from the bronchial arteries [23].…”

Section: Discussionmentioning

confidence: 99%

Combined Bronchial Artery Embolization and Endobronchial Resection for Bronchial Carcinoid: A Safety and Feasibility Pilot Study

Salamonsen

Tazi-Mezalek²,

López-Lisbona³

et al. 2015

Respiration

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Background: There is growing evidence to support bronchoscopic resection of well-circumscribed typical carcinoids. However, massive bleeding and risk of recurrence can potentially complicate this approach. Objectives: The aim of this study was to assess the safety and feasibility of endobronchial resection of carcinoids preceded by bronchial artery embolization. Methods: Five patients with centrally located typical carcinoids were recruited, 4 with a curative intent and 1 for palliation of a carcinoid with mediastinal invasion. All patients underwent selective embolization of the feeding bronchial artery 24-48 h prior to endobronchial resection, which was performed with a rigid bronchoscope and neodymium:yttrium-aluminium-perovskite laser. Results: Minimal bleeding was noted during tumour resection. After a median (range) follow-up of 20 (14-48) months, only the case with segmental extension of the tumour had local recurrence, which was treated successfully using cryotherapy (with negative endobronchial biopsies since), and no cases of metastatic spread occurred. One patient, in whom the histopathological diagnosis was changed from typical to atypical carcinoid following resection, went on to have a surgical bilobectomy 3 months later. Extensive fibrosis was noted at the site of original tumour resection with no evidence of residual disease. Conclusions: Bronchial artery embolization prior to endobronchial resection of centrally located carcinoids is feasible and safe. The reduction in bleeding may facilitate and simplify the procedure. The possible application of this combined therapy to the management of atypical carcinoids warrants the design of a larger prospective clinical trial.

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Section: Discussionmentioning

confidence: 99%

Combined Bronchial Artery Embolization and Endobronchial Resection for Bronchial Carcinoid: A Safety and Feasibility Pilot Study

Salamonsen

Tazi-Mezalek²,

López-Lisbona³

et al. 2015

Respiration

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“…Pneumonectomy has been reported for BC in children, 21,[32][33][34] but fortunately in more recent years the use of pneumonectomy has declined. 12,16 Clean transaction lines, minimal handling of mucosa, avoidance of devascularisation and precise placement of the suture are the bases for successful bronchoplastic techniques, 27 keeping in mind that in BC the resection can be performed with free margins of only 1-2 mm without an increase in the local recurrence rate. 30 The suture line can be covered with a pedicled flap of autologous tissue to reduce the potential risk of broncho-vascular fistula.…”

Section: Managementmentioning

confidence: 99%

Bronchial Carcinoid Tumours in Children — A Review

Rizzardi¹,

Bertolaccini²,

Terzi³

2011

European Oncology &Amp; Haematology

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Bronchial carcinoids (BCs) are rare, well-differentiated malignant neuroendocrine tumours that account for 2-5 % of all lung neoplasms in adults.In paediatric patients, carcinoids represent the most frequent primary lung cancer. Although BCs in childhood often have an endobronchial location causing airway obstruction, they are frequently misdiagnosed as benign conditions, resulting in a delay in definitive diagnosis and treatment. Surgery represents the treatment of choice for BCs, and lung-sparing resections (sleeve or bronchoplastic procedures) are recommended in central carcinoid tumours; pneumonectomy should be avoided, particularly in childhood. If promptly diagnosed and radically treated, BCs in children have an excellent prognosis. Relapses can occur many years after a radical resection, highlighting the necessity for long-term follow-up.

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“…2 The most common symptoms of bronchial carcinoid tumor are cough, hemoptysis, wheezing, weight loss, dyspnea, and chest pain. 3 Most of the tumors are found in the proximal part of the respiratory tract, where obstruction or hemorrhage is found as a symptom. Sometimes, cough, wheezing, hemoptysis, chest pain, or recurrent pneumonia may be repeatedly found in the same region.…”

Section: Discussionmentioning

confidence: 99%

A 14-year-old boy with endobronchial carcinoid tumor presenting with asthma

Gu¹,

Hwang²,

Kim³

2017

KMJ

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Endobronchial carcinoid tumor is the most common malignant pulmonary tumor of the childhood tumors, accounting for 50 to 80% of childhood tumors. Endobronchial carcinoid tumor is generally accompanied by symptoms such as cough, hemoptysis, wheezing, weight loss, dyspnea, and chest pain, as well as by radiological symptoms including atelectasis, sclerosing lesion, infiltration, and lump patterns. This case report is about a patient whose asthma had been treated for several years but was not properly regulated, and who showed a unilateral overinflation in the chest x-ray that was diagnosed as an endobronchial carcinoid tumor after additional tests. CASEA 14-year old, male, child patient who had been undergoing treatment for asthma in another hospital for three years due to repeated coughing, wheezing, and dyspnea visited our institution. The patient was hospitalized due to the exacerbation of his coughing, wheezing, and dyspnea, and underwent treatment using a bronchodilator, steroids, and a leukotriene receptor antagonist. However, since the Results: This case describes a 14-year-old boy, presenting with asthma-like symptoms throughout 3 years. He was treated as asthma but wax and wane. Chest x-ray showed an hyperlucent left lung, so we rechecked high resolution computed tomography (HRCT) for unilateral hyperinflation diseases diagnosis. It was found 1×1㎝ nodule in left main bronchus. We did bronchoscopy and discovered a round mass in the left bronchus, 2∼3㎝ away from carina. In the biopsy, it was bronchial carcinoid tumor, so we resected tumor. Discussion: Because symptoms of bronchial carcinoid tumors are various, it can often be misdiagnosed firstly. It is confused with asthma, pneumonia and foreign body. An additional examination were necessary when respiratory symptoms persist.

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Bronchial Carcinoid Tumors in Pediatric Patients

Cited by 92 publications

References 13 publications

Combined Bronchial Artery Embolization and Endobronchial Resection for Bronchial Carcinoid: A Safety and Feasibility Pilot Study

Combined Bronchial Artery Embolization and Endobronchial Resection for Bronchial Carcinoid: A Safety and Feasibility Pilot Study

Bronchial Carcinoid Tumours in Children — A Review

A 14-year-old boy with endobronchial carcinoid tumor presenting with asthma

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