Bronchial carcinoid tumors: A retrospective analysis of 126 patients

Harpole, David H.; Feldman, Jerome M.; Buchanan, Scott; Young, W. Glenn; Wolfe, Walter G.

doi:10.1016/0003-4975(92)91139-z

Cited by 192 publications

(122 citation statements)

References 29 publications

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“…Beasley et al found that increased numbers of mitoses, tumor size >3.5 cm, and female gender were negative predictors of survival, whereas smoking was not (3). The same is found in several other studies regarding smoking (12,13). In the present study, survival was associated with gender, Ki67-index, and metastatic disease at diagnosis.…”

Section: Discussionsupporting

confidence: 88%

“…Several studies concluded that smoking was not associated with bronchial carcinoid development, whereas two other studies found higher smoker prevalence among AC patients compared to healthy individuals or patients with TC (8-11). An association between smoking status and survival has not been demonstrated (3,9,12,13). Other predictors of mortality are histological type and stage at diagnosis (3, 9), whereas female gender was a negative predictor in one study (3).…”

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confidence: 99%

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Survival and Predictors of Death for Patients with Bronchopulmonary Carcinoid at a Danish Tertiary NET Centre

Kornerup

Dam

Grønbæk

2017

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Abstract. Background/Aim: Bronchopulmonary carcinoids comprise of typical carcioids (TC) and atypical carcinoids (AC). We present characteristics and associated mortality in patients with TC and AC followed-up Bronchopulmonary neuroendocrine tumors (BP-NETs) account for 20-25% of all neuroendocrine tumors and 20-25% of all lung cancer. BP-NETs comprise of typical carcinoids (TC), atypical carcinoids (AC), large-cell neuroendocrine carcinomas (LCNEC) and small-cell lung carcinomas (SCLC). Bronchial carcinoids (TC 80%, AC 20%) represent 1-2%, LCNEC <1%, and SCLC 10% of all lung cancer (1-4). TCs are considered low-grade and ACs intermediate-grade NETs while LCNECs and SCLCs are high-grade. Survival rates for each subtype reflect these differences. Five-year survival in a retrospective study of 12,345 patients diagnosed with BP-NET between 1978-1997 was 87% for TC, 44% for AC, 15% for LCNEC, and 2% in SCLC (5). However, other studies described 5-year survival of 87-100%, 61-88%, 15-57% and <5% for TC, AC, LCNEC and SCLC, respectively (1-3).Studies on cytogenetics found distinct chromosomal imbalances in BP-NET but to a lesser degree than SCLC. Genetic alterations were less widespread and involved narrower gene regions in BP-NET compared to SCLC, but several alterations were identical for both BP-NET and SCLC (6, 7).Studies investigating an association between smoking and development of AC and TC are conflicting. Several studies concluded that smoking was not associated with bronchial carcinoid development, whereas two other studies found higher smoker prevalence among AC patients compared to healthy individuals or patients with TC (8-11). An association between smoking status and survival has not been demonstrated (3,9,12,13). Other predictors of mortality are histological type and stage at diagnosis (3, 9), whereas female gender was a negative predictor in one study (3).The aim of the present study was to describe demographic, immunohistochemical, and biochemical characteristics, survival, and predictors of death for all patients diagnosed with bronchial carcinoid and referred to our

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Section: Discussionsupporting

confidence: 88%

mentioning

confidence: 99%

Survival and Predictors of Death for Patients with Bronchopulmonary Carcinoid at a Danish Tertiary NET Centre

Kornerup

Dam

Grønbæk

2017

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“…Bronchial carcinoids are neuroendocrine neoplasms arising from Kulchitsky cells of the bronchial epithelium representing 2 % of all primary lung carcinomas [2]. They are locally invasive indolent tumors with 10 to 15 % regional lymph node involvement [3].…”

Section: Discussionmentioning

confidence: 99%

Bronchoscopic Debulking Followed by Bronchoplastic Procedure Helps in Limiting Lung Resection in a Bronchial Carcinoid: A Case Report

Pandey

Ramanathan

Khurse

et al. 2014

Indian J Surg Oncol

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Bronchoplasty is a conservative procedure in lung surgeries used in the past for patients with poor functional status but recently these procedures have been performed in low grade malignant tumors of lung avoiding extensive morbid procedure like pneumonectomy without compromising the oncologic outcome. We describe a case of bronchial carcinoid treated by bronchoscopic intervention followed by wedge bronchoplasty. The importance of bronchoscopic debulking of the tumor for accurate assessment of its extent has been highlighted. A parenchyma preserving pulmonary resection can then be performed with bronchoplastic technique, thus avoiding pneumonectomy.

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“…20,26,27) The 5-year survival rate for patients with APCT ranges from 25% to 69%, which shows that APCT is essentially a malignant neoplasm. 1,4,5,7,11,15,16,23,25,28) APCT has a high potential for local and/or distant metastasis, frequently to the lymph nodes, liver, lungs, and bone. 1,4,5,7,11,15,16,23,25,28) Skull metastasis is a rare type of bone metastasis.…”

Section: Introductionmentioning

confidence: 99%

“…1,4,5,7,11,15,16,23,25,28) APCT has a high potential for local and/or distant metastasis, frequently to the lymph nodes, liver, lungs, and bone. 1,4,5,7,11,15,16,23,25,28) Skull metastasis is a rare type of bone metastasis. 19,21,22,29) We recently treated a 19-year-old man with skull metastases from APCT which were controlled by treatment, but he died of progression of the primary tumor.…”

Section: Introductionmentioning

confidence: 99%

Skull Metastases From Atypical Pulmonary Carcinoid Tumor in a 19-Year-Old Man-Case Report-

Isaka

Maruno

Suzuki

et al. 2006

Neurol. Med. Chir.(Tokyo)

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A 19-year-old man presented with a rare skull metastasis from atypical pulmonary carcinoid tumor (APCT) manifesting as headache, diplopia, and cough. Head magnetic resonance imaging showed a skull base tumor extending from the posterior clinoid process to the clivus, and calvarial tumors in the right temporal and occipital bones. Chest and abdominal computed tomography showed a round tumor, 4 cm in diameter, in the lower lobe of the right lung and multiple small tumors in the liver. Surgery for the calvarial tumor in the right temporal bone was performed on June 27, 2003. The histological diagnosis was skull metastasis of neuroendocrine tumor. Gamma knife radiosurgery was performed for the residual skull metastases. Partial resection of the right lower lobe was performed for the lung tumor on August 22, 2003. The histological diagnosis was atypical carcinoid tumor. Subsequent adjuvant systematic chemotherapy was performed. The patient died of progression of the tumors in the lung and liver on April 19, 2004. We must consider APCT in the differential diagnosis of pulmonary tumors in adolescents, and perform follow-up observation or treatment, including surgery, if APCT is suspected.

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Bronchial carcinoid tumors: A retrospective analysis of 126 patients

Cited by 192 publications

References 29 publications

Survival and Predictors of Death for Patients with Bronchopulmonary Carcinoid at a Danish Tertiary NET Centre

Survival and Predictors of Death for Patients with Bronchopulmonary Carcinoid at a Danish Tertiary NET Centre

Bronchoscopic Debulking Followed by Bronchoplastic Procedure Helps in Limiting Lung Resection in a Bronchial Carcinoid: A Case Report

Skull Metastases From Atypical Pulmonary Carcinoid Tumor in a 19-Year-Old Man-Case Report-

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