Bronchial asthma triggered by house dust mites in patients with local allergic rhinitis

Campo, Paloma; Eguiluz‐Gracia, Ibon; Plaza-Serón, María del Carmen; Salas, María; Rodrí­guez, Marí­a José; Pérez‐Sánchez, Natalia; González, Miguel; Molina, Ana; Mayorga, Cristobalina; Torres, Marı́a José; Rondón, Carmen

doi:10.1111/all.13775

Cited by 54 publications

(77 citation statements)

References 42 publications

(51 reference statements)

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“…Meanwhile, type 2 cytokine response bias characterized by an over‐production of interleukin (IL)‐4 (a cytokine that causes isotype class switching in B cells to produce IgE), IL‐5 (a cytokine that promotes eosinophil activation and recruitment), and IL‐13 (a cytokine that triggers mucus hypersecretion and airway hypersensitivity) can be observed in both upper and lower airways 9‐19 . Nasal allergen exposure tests in nonasthmatic AR patients result in eosinophilia in both upper and lower airway mucosa as well as peripheral blood 20,21 . These indicate that there exists a certain systemic linkage between the upper and lower airways.…”

Section: Introductionmentioning

confidence: 99%

Role of IL‐25, IL‐33, and TSLP in triggering united airway diseases toward type 2 inflammation

Hong

Liao

Chen

et al. 2020

Allergy

121

107

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Under the concept of "united airway diseases," the airway is a single organ wherein upper and lower airway diseases are commonly comorbid. The upper and lower airways are lined with respiratory epithelium that plays a vital role in immune surveillance and modulation as the first line of defense to various infective pathogens, allergens, and physical insults. Recently, there is a common hypothesis emphasizing epithelium‐derived cytokines, namely IL‐25, IL‐33, and TSLP, as key regulatory factors that link in immune‐pathogenic mechanisms of allergic rhinitis (AR), chronic rhinosinusitis (CRS), and asthma, mainly involving in type 2 inflammatory responses and linking innate and adaptive immunities. Herein, we review studies that elucidated the role of epithelium‐derived triple cytokines in both upper and lower airways with the purpose of expediting better clinical treatments and managements of AR, CRS, asthma, and other associated allergic diseases via applications of the modulators of these cytokines.

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Section: Introductionmentioning

confidence: 99%

Role of IL‐25, IL‐33, and TSLP in triggering united airway diseases toward type 2 inflammation

Hong

Liao

Chen

et al. 2020

Allergy

121

107

View full text Add to dashboard Cite

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“…Current published studies suggest that asthma symptoms are reported by 20-47% of LAR patients 12,13 In a recent study asthma was confirmed by methacholine test in 50% of LAR patients. 32 This proportion was found to increase to 83.3% and 57.9% in AR and NAR individuals, respectively. On the other hand, 28.8% and 83.3% of LAR and AR patients, respectively experienced a positive response in the bronchial allergen challenge (BAC), and none of the NAR or healthy control subjects did.…”

Section: Lar and Asthmamentioning

confidence: 87%

“…On the other hand, 28.8% and 83.3% of LAR and AR patients, respectively experienced a positive response in the bronchial allergen challenge (BAC), and none of the NAR or healthy control subjects did. 32 Investigators also found a significant increase in airway hyperreactivity measured by metacholine test after allergen exposure. Moreover, allergen administration induced a significant increase in sputum eosinophils, monocytes and ECP in BAC+ patients regardless of their atopic status, with no changes in BAC-individuals.…”

Section: Lar and Asthmamentioning

confidence: 93%

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Local allergic rhinitis: a pediatric perspective

Beken¹,

Eguiluz‐Gracia²,

Yazıcıoğlu³

et al. 2020

Turk J Pediatr

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Local allergic rhinitis (LAR) is a differentiated rhinitis phenotype defined by perennial or seasonal rhinitis symptoms without systemic atopy. The diagnosis can be made by a positive response to the nasal allergen challenge (NAC) (the gold standard for diagnosis) in the absence of skin prick test and/or serum allergenspecific immunoglobulin E. Clinical and epidemiological studies have demonstrated that LAR affects individuals from different countries, races, and age ranges. Several studies have shown that the onset of nasal symptoms occurs during childhood in a significant proportion of LAR individuals. Evidence of LAR has been growing, especially in pediatric and Asian populations. A review of the literature reveals that most LAR studies of pediatric populations have appeared in the last three years. The prevalence of LAR in children ranges from 3.7% to 66.6%, and similar to what has been observed in adults, prevalence is higher in Western countries. Publications have shown that LAR in children can be either seasonal or perennial, and diagnosis of LAR confirmed by NAC have been reported with numerous allergens (house dust mites, pollens, molds, and dander). These findings illustrate that LAR is an important differential diagnosis in children with presumed non-allergic rhinitis, and a through review of the very recent literature can contribute to the clinical identification and diagnosis of LAR in children with no evidence of systemic atopy, as well as update readers' knowledge of the topic.

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“…Первоначально энтопию не относили к разновидности атопии. В настоящее время этот [19,20], локальный аллергический конъюнктивит [21] и локальную аллергическую астму [22]. Среди всех энтопий наибольшее число исследований проведено в отношении локального аллергического ринита [19,20,[23][24][25][26].…”

Section: Source Of Financingunclassified

Allergic rhinitis and the phenomenon of entopy

et al. 2020

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Представлен обзор современных исследований, посвященных недавно открытому явлению-феномену энтопии (локальной атопии), с точки зрения его фенотипов и эндотипов. Клиническим вариантом эндотипа энтопии является локальный аллергический ринит, новая патология,-объект исследований в современной иммунологии, аллергологии и оториноларингологии. Точные механизмы срыва толерантности к аллергенам при энтопии остаются неясными. Между тем феномен энтопии может стать ключом для расшифровки нерешенных вопросов срыва аллергической толерантности в разных анатомических сайтах. Обзор посвящен патогенезу, диагностическому алгоритму и проблеме выбора терапевтических подходов при локальном аллергическом рините. Ключевые слова: aллергены, aтопия, энтопия, толерантность к аллергенам, aллергический ринит, локальный аллергический ринит, фенотипы, эндотипы, биомаркеры, Т-хелперы 2-го типа, T-регуляторные клетки. Конфликт интересов. Авторы декларируют отсутствие явных и потенциальных конфликтов интересов, связанных с публикацией настоящей статьи. Источник финансирования. Авторы заявляют об отсутствии финансирования.

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Bronchial asthma triggered by house dust mites in patients with local allergic rhinitis

Cited by 54 publications

References 42 publications

Role of IL‐25, IL‐33, and TSLP in triggering united airway diseases toward type 2 inflammation

Role of IL‐25, IL‐33, and TSLP in triggering united airway diseases toward type 2 inflammation

Local allergic rhinitis: a pediatric perspective

Allergic rhinitis and the phenomenon of entopy

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