Bronchial Asthma and Comorbid Diseases. Variants of No Synthetases Genetic Polymorphisms

Stafeev, A.N.; Логвиненко, Н. И.; Melnik, A. V.; Астраков, С. В.

doi:10.17513/spno.30062

Cited by 4 publications

(1 citation statement)

References 2 publications

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“…Изучение коморбидности -это актуальное направление в современной медицине, которое требует всестороннего анализа. Важно отметить, что влияние сопутствующих болезней на бронхиальную астму может быть разнообразным и определенно изменяет ее течение и прогноз [3,4]. Оксид азота (NO) играет особую роль в патогенезе бронхиальной астмы и сахарного диабета 2 типа, что вызывает повышенное внимание у ученых.…”

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Nos3 Gene Polymorphism (G894t) in Patients With a Combination of Bronchial Asthma and Type 2 Diabetes Mellitus

Pashkevich,

Serebryakova

2024

jour

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The aim of the research. We aimed to study the prevalence of genetic variants in the NOS3 gene (G894T) related to nitric oxide production in individuals with both asthma and type 2 diabetes.Materials and methods. The study was carried out among 240 patients suffering from asthma and diabetes type 2, dividing them into three groups for comparative analysis, each of which had 80 people. Clinical examination and molecular genetic analysis of the polymorphism of nitric oxide synthase NOS3 (G894T) was performed by PCR in all groups.Results. Patients suffering from type 2 diabetes and asthma have a high frequency of G-allele polymorphism NOS3 894G/T compared with those who have only type 2 diabetes or asthma. The G-allele of the NOS3 894G/T polymorphism contributes to an increased risk of developing diabetes type 2 in patients with asthma.Conclusion. The study of NOS3 polymorphism (G894T) may be useful to identify a group of patients with asthma who are at increased risk of diabetes type 2.

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Nos3 Gene Polymorphism (G894t) in Patients With a Combination of Bronchial Asthma and Type 2 Diabetes Mellitus

Pashkevich,

Serebryakova

2024

jour

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Features of the course and treatment of bronchial asthma combined with arterial hypertension: a review

Cherkashina,

Nikulina,

Averyanov

et al. 2024

Russian Medicine

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Bronchial asthma (BA) is a serious medical and social problem. Many patients with asthma have various concomitant chronic diseases, among which the pathology of the cardiovascular system occupies an important place. Most often, asthma occurs with arterial hypertension (AH). This concurrence can lead to mutual aggravation and progression of these diseases and may negatively affect the prognosis. Usually, difficulties appear when choosing the most effective therapy for BA along with hypertension. This review aimed to analyse the available publications on the problem of the combination of BA and hypertension. A review of the literature presents the summary, examines data on prevalence and indicates risk factors for the development of hypertension among patients with asthma. The coexistence of these diseases is more typical in older people. The review includes questions regarding the pathophysiology of this comorbidity. The role of impaired gas exchange and hypoxia, endothelial dysfunction, participation of the nitric oxide system and obesity in the development of hypertension in combination with asthma are highlighted. The significance of impaired nonrespiratory lung function is shown, and the inflammation features in this comorbid pathology are indicated, as well as the contribution of numerous genes to the development of asthma along with hypertension. In the literature, 330 common genes have been identified that may be involved in the molecular mechanisms of asthma and hypertension. This study shows the effect of concomitant hypertension on the course, asthma control and quality of life of the patients. In addition, the article shows modern approaches to effective therapy with the main groups of drugs used to treat these diseases. To date, studies have demonstrated the prevalence of the combination of asthma and hypertension in the structure of comorbidity, mutual influence and aggravation of these pathologies. Coexistence of BA and hypertension increases the severity of clinical symptoms. This article shows the important aspects of the treatment of a combination of diseases. The need for a thorough assessment of the safety of pharmacological therapy for BA along with hypertension has been demonstrated.

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Metabolic stress and stress-limiting mechanisms in bronchial asthma combined with type 2 diabetes mellitus

Skiba

2024

jour

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Objective: to study the indicators of lipid peroxidation and the antioxidant system in the blood and moisture condensate of exhaled air in patients with AD combined with type 2 diabetes, and in the blood of these patients — total metabolites of nitric oxide. Materials and methods: the study involved 215 patients with persistent BA of moderate severity aged (38.6±2.4) years, including 88 men (40.9%), 127 women (59.1%). Among the examined patients with BA there were 64 — group I, persons with BA combined with type 2 diabetes — 151 (group II). The parameters of the lipid peroxidation system (LPS) in the blood serum were studied: malondialdehyde (MDA), diene conjugates (DC), and the antioxidant system (AOS) according to the activity of catalase and superoxide dismutase (SOD), the amount of total metabolites of nitric oxide (NOx), in the condensate of exhaled air moisture (KEAM) was determined general oxidant (GOA) and antioxidant (AOA) activity. Results: in patients with BA combined with type 2 diabetes, an increase in the concentration of POL products in the blood was revealed: MDA was 2.6 times (p<0.05) compared with the control group and 1.3 times (p<0.05) compared with the indicator in patients with AD, DC, respectively, 2.0 times (p<0.05) compared with the control group and 1.2 times (p<0.05) compared with I group. The activity of the enzymes AOS catalase and SOD in patients with comorbidity of BA and type 2 diabetes was found to be lower than in patients of group I. In the KEAM of patients with comorbidity of BA and type 2 diabetes, a significant increase in OOA and a decrease in OAA were noted. The concentration of NOx in the blood serum of group II patients was 1.6 times higher than in the control group (p<0.05), but 1.4 times lower than in patients with AD without comorbidity with type 2 diabetes (p<0.05). The direction of the revealed correlations between the products of POL in blood serum and KEAM confirmed the systemic nature of metabolic changes in the body of patients with AD, and their strength in group II patients — the negative effect of comorbid type 2 diabetes on the greater severity of these metabolic changes. Conclusions: the resulting changes in the state of LPS and AOS in the blood and KEAM of patients with BA combined with type 2 diabetes can be characterized as systemic metabolic stress, both components of which: oxidative and nitrosive are supported by insufficient stress-limiting mechanisms — low activity of AOS enzymes and possible depletion of nitric oxide production, which should be reflected in the means of correcting metabolic disorders in patients with this comorbidity.

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Bronchial Asthma and Comorbid Diseases. Variants of No Synthetases Genetic Polymorphisms

Cited by 4 publications

References 2 publications

Nos3 Gene Polymorphism (G894t) in Patients With a Combination of Bronchial Asthma and Type 2 Diabetes Mellitus

Nos3 Gene Polymorphism (G894t) in Patients With a Combination of Bronchial Asthma and Type 2 Diabetes Mellitus

Features of the course and treatment of bronchial asthma combined with arterial hypertension: a review

Metabolic stress and stress-limiting mechanisms in bronchial asthma combined with type 2 diabetes mellitus

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