Bronchial allergen provocation: A useful method to assess the efficacy of specific immunotherapy in children

Rosewich, Martin; Arendt, Sonja; Moussaoui, Samir El; Schulze, Johannes; Schubert, Ralf; Zielen, Stefan

doi:10.1111/pai.12068

Cited by 29 publications

(32 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Studies of Rosewich et al . with immunotherapy against house dust mites showed significantly decreased sIgE after subcutaneous immunotherapy (SCIT), but this reduction was not able to discriminate between responders and non-responders in the SCIT group [26]. …”

Section: Discussionmentioning

confidence: 99%

Specific immunotherapy with mugwort pollen allergoid reduce bradykinin release into the nasal fluid

Gawlik

Grzanka

Jawor

et al. 2016

pdia

View full text Add to dashboard Cite

IntroductionA pathomechanism of allergic rhinitis is complex. A neurogenic mechanism seems to play a significant role in this phenomenon.AimThe evaluation of influence of specific immunotherapy of mugwort pollen allergic patients on the bradykinin concentration in the nasal lavage fluid.Material and methodsThe study included 22 seasonal allergic rhinitis patients. Thirty persons with monovalent allergy to mugwort pollen, confirmed with skin prick tests and allergen-specific immunoglobulin E, underwent a 3-year-long allergen immunotherapy with the mugwort extract (Allergovit, Allergopharma, Germany). The control group was composed of 9 persons with polyvalent sensitivity to pollen, who were treated with pharmacotherapy. Before the allergen-specific immunotherapy (AIT) and in subsequent years before the pollen seasons, a provocation allergen test with the mugwort extract was performed, together with collection of nasal fluids, where bradykinin concentration was determined according to Proud method.ResultsThere were similar levels of bradykinin in both groups at baseline prior to therapy (AIT group: 584.0 ±87.2 vs. controls 606.3 ±106.5 pg/ml) and changes after allergen challenge 1112.4 ±334.8 vs. 1013.3 ±305.9 pg/ml as well. The bradykinin concentration in nasal lavage fluid after mugwort challenge in 1 year was lower in the AIT group (824.1 ±184.2 pg/ml vs. 1000.4 ±411.5 pg/l; p < 005) with a further significant decrease after the 2nd and 3rd year of specific immunotherapy. Significant reduction of symptoms and medications use was observed in hyposensitized patients.ConclusionsA decreased level of bradykinin as a result of AIT suggests that some of the symptomatic benefits of AIT may be related to the reduced release of bradykinin into nasal secretions. These values correlate with clinical improvement within the course of treatment.

show abstract

Section: Discussionmentioning

confidence: 99%

Specific immunotherapy with mugwort pollen allergoid reduce bradykinin release into the nasal fluid

Gawlik

Grzanka

Jawor

et al. 2016

pdia

View full text Add to dashboard Cite

show abstract

“…The first step covered an inhalation of 5 SBU/mL. Afterwards, the dose was doubled until a decrease of FEV1 ≥ 20% was reached or a cumulative dose of 635 SBU/mL was administered …”

Section: Methodsmentioning

confidence: 99%

“…Earlier studies from our working group showed that BAP is a safe and highly reproducible method in children and adults suffering from respiratory diseases . Although great effort has been put into standardizing the procedure, BAP is still rarely used by clinicians due to possible side‐effects and the fear of severe asthmatic reactions . For safety reasons, only patients with mild CF (FEV1 > 75%) and proven sensitization to A fumigatus underwent BAP.…”

Section: Introductionmentioning

confidence: 99%

Clinical relevance of Aspergillus fumigatus sensitization in cystic fibrosis

Eickmeier

Zissler

Wittschorek

et al. 2020

Clin Experimental Allergy

Self Cite

View full text Add to dashboard Cite

Rationale The clinical relevance of sensitization to Aspergillus (A) fumigatus in cystic fibrosis (CF) is unclear. Some researchers propose that specific A fumigatus IgE is an innocent bystander, whereas others describe it as the major cause of TH‐2‐driven asthma‐like disease. Objectives Lung function parameters in mild CF patients may be different in patients with and without A fumigatus sensitization. We aimed to ascertain whether allergen exposure to A fumigatus by bronchial allergen provocation (BAP) induces TH‐2 inflammation comparable to an asthma‐like disease. Methods A total of 35 patients, aged 14.8 ± 8.5 years, and 20 healthy controls were investigated prospectively. The patients were divided into two groups: group 1 (n = 18): specific (s)IgE negative, and group 2 (n = 17): sIgE positive (≥0.7 KU/L) for A fumigatus. Lung function, exhaled NO, and induced sputum were analysed. All sensitized patients with an FEV1 > 75% (n = 13) underwent BAP with A fumigatus, and cell counts, and the expression of IL‐5, IL‐13, INF‐γ, and IL‐8 as well as transcription factors T‐bet, GATA‐3, and FoxP3, were measured. Results Lung function parameters decreased significantly compared to controls, but not within the CF patient group. After BAP, 8 of 13 patients (61%) had a significant asthmatic response and increased eNO 24 hours later. In addition, marked TH‐2‐mediated inflammation involving eosinophils, IL‐5, IL‐13, and FoxP3 became apparent in induced sputum cells. Conclusion Our study demonstrated the clinical relevance of A fumigatus for the majority of sensitized CF patients. A distinct IgE/TH‐2‐dominated inflammation was found in induced sputum after A fumigatus exposure.

show abstract

“…Pediatric data are scarce due to safety and feasibility concerns. Rosewich et al evaluated SIT in house‐dust‐mite allergic children with BAP compared to established tools, such as symptom‐ and medication‐scores and surrogate markers (e.g., IgE and IgG4). The authors could clearly demonstrate that BAP is feasible and safe in children older than five years of age.…”

Section: Bronchial Allergen Provocation: a Useful Methods To Assess Thmentioning

confidence: 99%

The Editor recommends this issue's articles to the reader

2013

Pediatric Allergy Immunology

View full text Add to dashboard Cite

Bronchial allergen provocation: A useful method to assess the efficacy of specific immunotherapy in children

Cited by 29 publications

References 22 publications

Specific immunotherapy with mugwort pollen allergoid reduce bradykinin release into the nasal fluid

Specific immunotherapy with mugwort pollen allergoid reduce bradykinin release into the nasal fluid

Clinical relevance of Aspergillus fumigatus sensitization in cystic fibrosis

The Editor recommends this issue's articles to the reader

Contact Info

Product

Resources

About