Bromosulfophthalein disposition in chronically bile duct obstructed rats

Yaari, A; Sikuler, Emanuel; Keynan, Arie; Ben‐Zvi, Zvi

doi:10.1016/0168-8278(92)90013-f

Cited by 6 publications

(1 citation statement)

References 27 publications

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“…Hepatomegaly, in turn, is secondary to biliary retention and subsequent obstruction of biliary drainage, which ultimately leads to liver fibrosis[13,14,36]. Using a model of liver damage induced by administration of polychlorinated biphenyls, Oliveira et al[33] found that splenomegaly was minimal in exposed animals given the antioxidant quercetin.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant and anti-inflammatory action of melatonin in an experimental model of secondary biliary cirrhosis induced by bile duct ligation

Colares¹,

Schemitt²,

Hartmann³

et al. 2016

WJG

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AIMTo evaluate the effects of melatonin (Mel) on oxidative stress in an experimental model of bile duct ligation (BDL).METHODSMale Wistar rats (n = 32, weight ± 300 g) were allocated across four groups: CO (sham BDL), BDL (BDL surgery), CO + Mel (sham BDL and Mel administration) and BDL + Mel (BDL surgery and Mel administration). Mel was administered intraperitoneally for 2 wk, starting on postoperative day 15, at a dose of 20 mg/kg.RESULTSMel was effective at the different standards, reestablishing normal liver enzyme levels, reducing the hepatosomatic and splenosomatic indices, restoring lipoperoxidation and antioxidant enzyme concentrations, reducing fibrosis and inflammation, and thereby reducing liver tissue injury in the treated animals.CONCLUSIONThe results of this study suggest a protective effect of Mel when administered to rats with secondary biliary cirrhosis induced by BDL.

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