Bromodomain Protein-directed Agents and MYC in Small Cell Lung
Cancer
Gerhard Hamilton,
Sandra Stickler,
Barbara Rath
Abstract:Abstract::
Small cell lung cancer (SCLC) has a dismal prognosis. In addition to the inactivation of
the tumor suppressors TP53 and RB1, tumor-promoting MYC and paralogs are frequently overexpressed
in this neuroendocrine carcinoma. SCLC exhibits high resistance to second-line chemotherapy
and all attempts of novel drugs and targeted therapy have failed so far to achieve superior
survival. MYC and paralogs have key roles in the oncogenic process, orchestrating proliferation,
apoptosis, differentiation, and meta… Show more
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