Bromodimethylsulfonium Bromide (BDMS)-Catalyzed Synthesis of 1,5-Benzodiazepines Using a Multi-Component Reaction Strategy

Abstract

A new approach for the synthesis of multi-functionalized 1,5-benzodiazepines is developed starting from o-phenylenediamines, β-keto esters and aromatic aldehydes utilizing a one-pot, three-component strategy employing bromodimethylsulfonium bromide as the catalyst. The simple reaction procedure, good yields, mild reaction conditions and applicability to a wide range of substrates are some of the salient features of this protocol.

The Role of (BDMS) Bromodimethylsulfonium bromide as a Catalyst and Brominating Reagent: A Concise Overview

“…A novel synthetic procedure was reported by Sarkar et al for the formation of bioactive heterocyclic compounds via multicomponent reactions and to explore the efficacy of bromodimethylsulfonium bromide for the preparation of 1, 5benzodiazepine derivatives (Scheme 7). [16] The prominent features of this method are excellent yields, mild and fresh reaction conditions, solvent-free reaction conditions and better atom economy makes this method superior than the other existing methods.…”