Bromocriptine-induced dissociation of hyperglycemia and prolactin response to restraint

Ribeiro-de-Oliveira, A; Guerra, Rachel Menezes; Fóscolo, Rodrigo Bastos; Marubayashi, Umeko; Reis, Adelina Martha dos; Coimbra, Cândido Celso

doi:10.1016/s0091-3057(00)00453-6

Cited by 9 publications

(8 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is known that PRL plays an essential role in milk synthesis and secretion during lactation and it is needed for the onset of lactation and maintenance. Moreover, the PRL concentration is also positively correlated with mammary gland wet weight (Farmer, 2001 PRL secretion and decreases plasma PRL levels in rats (Ribeiro-De-Oliveira et al, 2001). The observed effect of bromocriptine on PRL concentrations was associated with changes in PRL levels in our study.…”

Section: Discussionsupporting

confidence: 67%

Therapeutic Effect of Cuirutang on Maternal Rats with Hypogalactia Induced by Bromocriptine

Dong¹,

Li²,

Bian³

et al. 2015

International J. of Pharmacology

View full text Add to dashboard Cite

To study the galactagogue effect of Cuirutang (a new traditional Chinese lactogenic decoction) on rats with postpartum hypogalactia, maternal rats were fed bromocriptine to induce hypogalactia and were subsequently treated with Cuirutang. The galactagogue effects of Cuirutang were evaluated based on changes in milk production, the prolactin level and the amount of prolactin receptor in the mammary gland as well as based on mass gains in the pups and mammary glands of maternal rats. The results demonstrated that Cuirutang significantly increased milk production (p<0.01), prolactin levels (p<0.05) and mammary gland parameters (p<0.05) during puerperal hypogalactia. The mass gain of the suckling pups was also significantly increased (p<0.05). In addition, Cuirutang markedly diminished the postpartum hypogalactia and mastatrophy effects induced by bromocriptine. These results demonstrate that Cuirutang was capable of improving the lactation function of maternal rats.

show abstract

Section: Discussionsupporting

confidence: 67%

Therapeutic Effect of Cuirutang on Maternal Rats with Hypogalactia Induced by Bromocriptine

Dong¹,

Li²,

Bian³

et al. 2015

International J. of Pharmacology

View full text Add to dashboard Cite

show abstract

“…Thus, the recovery effect of MG on BDG level may result from MG activating BDG level and glucose tolerance. In contrast, previous results showed that RS induced hyperglycemia [ 22 , 25 - 27 ]. Different measurement times for BDG level may result in different findings, such as hyperglycemia and hypoglycemia.…”

Section: Discussionmentioning

confidence: 58%

Anti-Depressant Like Effect of Methyl Gallate Isolated fromAcer barbinervein Mice

Lee

2013

Korean J Physiol Pharmacol

View full text Add to dashboard Cite

In the present study, the anti-depressant like effect of methyl gallate (MG) isolated from the stem bark of Acer barbinerve was examined in ICR mice. Body weight (BDW) and blood glucose (BDG) levels significantly decreased in the repeated restraint stress (RRS) group (2 h/day for 14 days) compared to the no stress (NS) group. To examine the effect of MG on RS-induced BDW loss and hypoglycemia, MG (10 mg/kg) and the anti-depressant fluoxetine (10 mg/kg) were administered daily for 14 days. Orally administered MG and fluoxetine significantly attenuated the RS-induced BDW loss and hypoglycemia. Interestingly, MG administered mice showed increased BDG levels in the normal and glucose feeding condition. Chronic RS-subjected mice showed immobilized and depressed behaviors. The effect of MG on the depressed behaviors was evaluated using the tail-suspension test (TST) and the forced swimming test (FST). In both tests, RS-induced immobilized behaviors were significantly reversed in MG and fluoxetine administered groups. Taken together, MG significantly attenuated the RS-induced BDW loss, hypoglycemia, and depressed behaviors. Considering that decreased BDG levels (hypoglycemia) can cause depression, MG may exert its anti-depressant like effect by preventing hypoglycemia. Our results suggest that MG isolated from A. barbinerve can exert anti-depressant like effect, and could be used as a new and natural anti-depressant therapy.

show abstract

“…Chronic treatment with bromocriptine [2‐bromo‐ergocriptine (BR)] has been described as altering autonomic response to stress including metabolic adjustments, such as hyperglycaemia and the sympathetic inhibition of insulin secretion (Ribeiro de Oliveira et al. , 1999, 2001; Ribeiro Oliveira et al.…”

Section: Introductionmentioning

confidence: 99%

“…, 1999). Considering that BR treatment alters autonomic tone, it is reasonable to suppose that other metabolic adjustments to stress dependent on autonomic regulation, such as free fatty acids (FFA) mobilization from adipose tissue and lactate production/utilization, would also be modified by chronic BR treatment (Ribeiro de Oliveira et al. , 1999, 2001; Ribeiro Oliveira et al.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Chronic treatment with bromocriptine modifies metabolic adjustments in response to restraint stress in rats

Balthazar

Oliveira

Marubayashi

et al. 2007

Auton Autocoid Pharmacol

View full text Add to dashboard Cite

1. We investigated the influence of bromocriptine (BR) chronic treatment in the autonomic adjustments to energetic metabolism during restraint stress (RS). To achieve this, Wistar male rats were chronically treated with BR before the application of RS. The rats were divided into two groups: those treated with BR and control rats, treated with saline. 2. Chronic treatment with BR did not affect rat growth and induced a 20% higher basal plasma glucose concentration. During RS, BR rats presented higher plasma glucose concentrations than the control animals. Despite this, the 30-min analysis of the areas under the glucose curve showed that the control rats presented a hyperglycemic response to RS two-fold greater than the BR rats. 3. RS induced an increase in plasma lactate concentration in both groups of rats; however, the 30-min analyses under the lactate curves showed that BR rats presented a lactate response to RS three times higher than control rats. 4. RS induced an increase in plasma free fatty acids (FFA) concentration in both groups; however, plasma FFA concentration of BR rats returned to the basal values at the end of RS. In contrast, in the control group, this concentration continued to rise until the end of RS. 5. The results showed that BR chronic treatment shifts the balance of substrate utilization in response to RS, suggesting that the essential role of lactate in the metabolism homeostasis may be altered by chronic BR treatment.

show abstract

Bromocriptine-induced dissociation of hyperglycemia and prolactin response to restraint

Cited by 9 publications

References 38 publications

Therapeutic Effect of Cuirutang on Maternal Rats with Hypogalactia Induced by Bromocriptine

Therapeutic Effect of Cuirutang on Maternal Rats with Hypogalactia Induced by Bromocriptine

Anti-Depressant Like Effect of Methyl Gallate Isolated fromAcer barbinervein Mice

Chronic treatment with bromocriptine modifies metabolic adjustments in response to restraint stress in rats

Contact Info

Product

Resources

About