Bromocriptine dose and severity of Parkinson's disease

Jd, Grimes

doi:10.1212/wnl.35.4.614-a

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Evidence For the Early Use Of Dopamine Agonists1

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1999

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“…Unfortunately, there is a relatively high non-response rate and adverse events are common. 57,58 Pergolide has not been extensively studied as early monotherapy.…”

Section: Evidence For the Early Use Of Dopamine Agonistsmentioning

confidence: 99%

Treatment of Early Parkinson's Disease

Grimes

Lang

1999

Can. J. Neurol. Sci.

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The early treatment of Parkinson's disease continues to be controversial as our understanding of the etiology of the disease remains incomplete. Ideally an intervention that reverses or protects against further damage to dopaminergic neurons would be initiated once the symptoms of the disease are recognized. Unfortunately, there are no currently available therapies that have been shown to have a major impact on the progression of the disease. However, delaying effective symptomatic therapy beyond a point of significant disability does result in increased mortality. Concerns have been raised regarding the potential toxicity of levodopa on remaining nigral neurons. Although there is little support for this concept, levodopa is associated with important complications. The development of new symptomatic treatments has made the management of early Parkinson's disease even more complex and requires that many different factors be considered prior to initiating therapy in an attempt to minimize current and future disability caused by the disease and its treatment.

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“…Unfortunately, there is a relatively high non-response rate and adverse events are common. 57,58 Pergolide has not been extensively studied as early monotherapy.…”

Section: Evidence For the Early Use Of Dopamine Agonistsmentioning

confidence: 99%

Treatment of Early Parkinson's Disease

Grimes

Lang

1999

Can. J. Neurol. Sci.

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show abstract

Bromocriptine dose and severity of Parkinson's disease

Cited by 1 publication

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Treatment of Early Parkinson's Disease

Treatment of Early Parkinson's Disease

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