Bromo<i>iso</i>butyramide as an Intermolecular Surface Binder for the Preparation of Free‐standing Biopolymer Assemblies

Mertz, Damien; Tan, Pramudana; Wang, Yajun; Goh, Tor Kit; Blencowe, Anton; Caruso, Frank

doi:10.1002/adma.201102890

Cited by 42 publications

(48 citation statements)

References 29 publications

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“…Tetraethyl orthosilicate (TEOS) (Sigma–Aldrich), cetyltrimethylammonium bromide (CTAB) (ROTH, >98 %), aminopropyltriethoxysilane (APTES) (Sigma Aldrich), isobutyramide chloride (IBC) (Sigma Aldrich), ammonium hydroxide (25 % in water) (Fluka), triethylamine (Sigma Aldrich), sodium hydroxide (Carlo Elba), ammonium nitrate (Sigma Aldrich, >99 %), human serum albumin (HSA) (Sigma Aldrich, >97 %), rhodamine B isothiocyanate (RITC) (Sigma Aldrich), curcumin (Sigma Aldrich), camptothecin (CPT) (Enzo Life Science), dimethylformamide (DMF) (Carlo Elba) were used as received, without further purification. The HSA functionalized with RITC fluorophore (HSA RITC ) has been prepared according to previous protocols from Mertz et al …”

Section: Methodsmentioning

confidence: 99%

“…Procedure for the silica dissolution with HF : This method was adapted from Mertz et al . Mesoporous silica coated materials dispersed in aqueous solution were mixed with HF/NH 4 F (2/7 m ) in 1:1 proportion and let the dissolution occurs during 10 min.…”

Section: Methodsmentioning

confidence: 99%

“…Indeed, MS may be coated with proteins and further used as a suitable sacrificial matrix template for the formation of thin self‐supported protein films. Recently, we pioneered a new strategy based on the use of isobutyramide (IBAM) grafts and silica templates to form innovative non‐covalent but strongly bound macromolecular nanoassemblies . IBAM groups and their derivatives (BrIBAM) grafted at silica surfaces were shown to behave as versatile non‐covalent surface binders to form physically stable cross‐linked nanofilms through a single step adsorption of macromolecules.…”

Section: Introductionmentioning

confidence: 99%

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Design of Protein‐Coated Carbon Nanotubes Loaded with Hydrophobic Drugs through Sacrificial Templating of Mesoporous Silica Shells

Fiegel

Harlepp

Bégin

et al. 2018

Chemistry A European J

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One key challenge in the fields of nanomedicine and tissue engineering is the design of theranostic nanoplatforms able to monitor their therapeutic effect by imaging. Among current developed nano-objects, carbon nanotubes (CNTs) were found suitable to combine imaging, photothermal therapy, and to be loaded with hydrophobic drugs. However, a main problem is their resulting low hydrophilicity. To face this problem, an innovative method is developed here, which consists in loading the surface of carbon nanotubes (CNTs) with drugs followed by a protein coating around them. The originality of this method relies on first covering CNTs with a sacrificial template mesoporous silica (MS) shell grafted with isobutyramide (IBAM) binders on which a protein nanofilm is strongly adhered through IBAM-mediated physical cross-linking. This concept is first demonstrated without drugs, and is further improved with the suitable loading of hydrophobic drugs, curcumin (CUR) and camptothecin (CPT), which are retained between the CNTs and human serum albumin (HSA) layer. Such novel nanocomposites with favorable photothermal properties are very promising for theranostic systems, drug delivery, and phototherapy applications.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Design of Protein‐Coated Carbon Nanotubes Loaded with Hydrophobic Drugs through Sacrificial Templating of Mesoporous Silica Shells

Fiegel

Harlepp

Bégin

et al. 2018

Chemistry A European J

Self Cite

View full text Add to dashboard Cite

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“…The molecular conformation of proteins could be somehow transformed by such a treatment, which thus principally enhances hydrophobic interactions between protein molecules. Such intermolecular forces within protein particles are not sufficiently robust to retain the stability against dilution in vitro and in vivo 33–35. Therefore, it remains a remarkable challenge to design and fabricate well‐defined protein‐based colloids with multifunctional properties for nanomedicine and other biological applications by a facile, but green route.…”

Section: Introductionmentioning

confidence: 99%

Nanoengineering of Stimuli‐Responsive Protein‐Based Biomimetic Protocells as Versatile Drug Delivery Tools

Zhao

Shen

Chen

et al. 2014

Chemistry A European J

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We present a general strategy to nanoengineer protein-based colloidal spheres (biomimetic protocells) as versatile delivery carriers with stimuli responsiveness by the electrostatic assembly of binary components (proteins and polypeptides) in association with intermolecular disulfide cross-linking. The size of the colloidal spheres, ranging from nanoscale to microscale, is readily tuned through parameters like protein and polypeptide concentration, the ratio between both, pH, and so on. Moreover, such colloidal spheres show versatile encapsulation of various guest molecules including small organic molecules and biomacromolecules. The pH and redox dual-responsiveness facilitates the rapid release of the payload in an acidic and reductant-enriched ambient such as in lysosomes. Thus, nanoengineering of protein-based biomimetic protocells opens a new alternative avenue for developing delivery vehicles with multifunctional properties towards a range of therapeutic and diagnostic applications.

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“…Mertz et al designed theranostic nanoparticles based on human serum albumin for simultaneous gene silencing and MRI applications [165]. The researchers described an effective method based on the use of isobutyramide grafts and their derivatives to assemble different biomacromolecules, composing proteins, at interfaces or in freestanding form [165,166]. Nanoparticles were covalently grafted with macrocyclic gadolinium complexes (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid-Gd) as an MRI contrast agent.…”

Section: Organic Nanoparticlesmentioning

confidence: 99%

Oligonucleotide-Based Theranostic Nanoparticles in Cancer Therapy

Shahbazi

Özpolat

Ulubayram

2016

Nanomedicine (Lond.)

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Theranostic approaches, combining the functionality of both therapy and imaging, have shown potential in cancer nanomedicine. Oligonucleotides such as small interfering RNA and microRNA, which are powerful therapeutic agents, have been effectively employed in theranostic systems against various cancers. Nanoparticles are used to deliver oligonucleotides into tumors by passive or active targeting while protecting the oligonucleotides from nucleases in the extracellular environment. The use of quantum dots, iron oxide nanoparticles and gold nanoparticles and tagging with contrast agents, like fluorescent dyes, optical or magnetic agents and various radioisotopes, has facilitated early detection of tumors and evaluation of therapeutic efficacy. In this article, we review the advantages of theranostic applications in cancer therapy and imaging, with special attention to oligonucleotide-based therapeutics.

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Bromoisobutyramide as an Intermolecular Surface Binder for the Preparation of Free‐standing Biopolymer Assemblies

Cited by 42 publications

References 29 publications

Design of Protein‐Coated Carbon Nanotubes Loaded with Hydrophobic Drugs through Sacrificial Templating of Mesoporous Silica Shells

Design of Protein‐Coated Carbon Nanotubes Loaded with Hydrophobic Drugs through Sacrificial Templating of Mesoporous Silica Shells

Nanoengineering of Stimuli‐Responsive Protein‐Based Biomimetic Protocells as Versatile Drug Delivery Tools

Oligonucleotide-Based Theranostic Nanoparticles in Cancer Therapy

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