Bromineless Bromine as an Efficient Desulfurizing Agent for the Preparation of Cyanamides and 2-Aminothiazoles from Dithiocarbamate Salts

Yella, Ramesh; Kavala, Veerababurao; Patel, Bhisma K.

doi:10.1080/00397911003642658

Cited by 12 publications

(1 citation statement)

References 24 publications

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“…Oxidative desulfurization of the in situ generated thiourea 27 is the key step of this synthesis (Scheme 11). Molecular iodine 29 or brominating agent 1,2-ethylenedipyridinium bistribromide (EDPBT) 30 can also be employed as oxidant.…”

Section: Desulfurization Of Thioureasmentioning

confidence: 99%

The Cyanamide Moiety, Synthesis and Reactivity

et al. 2012

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The cyanamide moiety provides many opportunities as a building block for the synthesis of nitrogen-containing heterocycles. This review discusses the reported methods for the preparation of alkyl-and N-acylcyanamides and illustrates their reactivity visà-vis nucleophilic additions, cycloadditions, radical chemistry and coordination chemistry. 1 Introduction 2 Biological Relevance of the Cyanamide Moiety 3 Access to Cyanamides 3.1 Cyanation of Amines 3.2 Palladium Catalysis 3.3 Deoxygenation of Isocyanates 3.4 Desulfurization of Thioureas 4 Reactivity of Cyanamides 4.1 Nucleophilic Additions 4.2 Cycloadditions 4.3 Additions to Carbonyl Groups 4.4 Chlorinations and Oxidations with tert-Butyl-N-chlorocyanamide 4.5 Cyanamides as Radical Partners 5 Coordination Chemistry of Cyanamides 6 Conclusion

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Section: Desulfurization Of Thioureasmentioning

confidence: 99%

The Cyanamide Moiety, Synthesis and Reactivity

et al. 2012

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KI‐assisted Sulfur Activation/Insertion/Denitration Strategy towards Dual C−S Bond Formation for One‐pot Synthesis of β‐Carboline‐tethered 2‐Acylbenzothiophenes

Singh

Jamra

et al. 2022

Asian J Org Chem

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A simple and efficient KI promoted sulfur activation‐insertion/de‐nitration strategy has been developed for the synthesis of β‐carboline C1 tethered 2‐acylbenzothiophenes via one‐pot assembly of 1‐acetyl β‐carbolines (an alkaloid based scaffold), 2‐nirobenzaldehydes and elemental sulfur. This expeditious reaction proceeds through the formation of β‐carboline linked nitro‐chalcones followed by embodiment of elemental sulfur to generate the multifunctional β‐carboline linked benzothiophene derivatives. The highlighted features of this efficient methodology are transition metal‐free conditions, use of inexpensive and non‐toxic catalyst, easy procedure, short reaction time, and broad substrate scope with good yields. The scope of this protocol has been extended for the synthesis of a range of novel compounds with significant diversity.

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