Brominated Radiopaque Liposomes

Radiopaque Liposomes: Effect of Formulation Conditions on Encapsulation Efficiency

“…Some attempts, including the preparation of brominated radiopaque liposomes (7) and the encapsulation of diatrizoic acid salts within liposomes (8), have already been performed, yielding preliminary results that are promising. The radiopaque agent, sodium ioxitalamate (I), is primarily used for urography because of its pharmacokinetic properties, ( 5 6 ) ; however, side COONa I * ' CH,---CO-HN CO-NH-CH,--CH,OH I I effects, allergic reactions, and intolerance have been reported.…”

Liposomes in diagnostic radiology

“…We proposed to use liposomes to carry contrast agents (Caride,198 l), and evaluated liposomes prepared with iodinated phospholipids and with brominated phospholipids (Caride et al, 1982). Another approach is the use of liposomes loaded with diatrizoate, a conventional contrast agent, to achieve contrast enhancement of the spleen and liver (Havron et al, 1981).…”

Gold-coated plant virus as computed tomography imaging contrast agent

“…NPs, such as QDs and magnetic NPs, generate a contrast signal that is unmatched by smaller chemical counterparts [11]. Although iodine-based contrast agents are the most commonly used CT contrast agents nowadays [12], a variety of materials have been used as CT contrast agents including gold nanoparticles (AuNPs) [13], bromine [14], platinum [15], ytterbium [16], gadolinium [4], and tungsten [15]. Many of the systems are made up of a core that is coated with a polymeric material such as liposomes [17], micelles [13], lipoproteins or polymeric nanoparticles [18].…”

“…One of the first examples of such NP-based systems was reported by Caride et al using brominated phospholipids packaged into liposomes and administered to dogs. Contrast enhancement signals of 40 HU were observed in the liver of imaged animals [14]. Two hours after injection, micelles loaded with 17.7 wt % of iodine at a dose of 170 mg of iodine per kilogram were able to show an attenuation of 150 HU in the heart [19], 57 HU in the liver and 90 HU in the spleen [20].…”