Brominated Flame Retardants in Edible Fishes from Three Gorges Reservoir, China

Ding, Xiangyi; Liu, Jiahong; Wen, Wu

doi:10.24850/j-tyca-2019-04-03

Cited by 4 publications

(1 citation statement)

References 33 publications

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“…As an additive flame retardant, PBBs are slowly released into the environment and taken up by the organisms [ 2 ]. Researchers have detected PBBs in mussels [ 3 ], fish [ 4 , 5 , 6 ], birds [ 7 ], etc., with the highest concentration reaching 12.4 ng/g. Even after 40 years of the Michigan pollution incident, PBBs are still detected in the human serum in the Michigan area [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Establishment of a CoMFA Model Based on the Combined Activity of Bioconcentration, Long-Range Transport, and Highest Infrared Signal Intensity and Molecular Design of Environmentally Friendly PBB Derivatives

Yang

Liu

2021

Polymers

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In the current study, a comparative molecular field analysis (CoMFA) model with the combined activity of polybrominated biphenyls (PBBs) bioconcentration, long-range transport, and the highest infrared signal intensity (weight ratio of 5:4:1) was constructed based on the threshold method and was further evaluated and analyzed. PBB-153 derivatives with improved combined activity values of bioconcentration, long-range transport, and the highest infrared signals intensity were designed based on contour maps of the CoMFA model. The environmental stability and functionality of the derivatives were also evaluated. The constructed model showed good prediction ability, fitting ability, stability, and external prediction ability. The contribution rates of electrostatic and steric fields to the combined activity of PBBs were 53.4% and 46.6%, respectively. Four PBB-153 derivatives with significantly improved bioconcentration, long-range transport and the highest infrared signal intensity (the combined activity value of these three parameters decreased) were screened with good environmental stability and functionality. Results validated the accuracy and reliability, and ability of the generated model to realize the simultaneous modification of the three activities of the target molecule. The binding ability of the designed derivatives to food chain biodegradation enzymes increased, thereby verifying the improvement in the bioconcentration. The half-lives of the derivatives in air and their ability to be absorbed by the plants significantly improved compared to the target molecule, further showing that the long-range transport of derivatives was reduced. In addition, the introduction of the –NO group caused the N =O stretching vibration of the derivatives to increase the infrared signal intensity. The present model provides a theoretical design method for the molecular modification of environmentally friendly PBBs.

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Section: Introductionmentioning

confidence: 99%

Establishment of a CoMFA Model Based on the Combined Activity of Bioconcentration, Long-Range Transport, and Highest Infrared Signal Intensity and Molecular Design of Environmentally Friendly PBB Derivatives

Yang

Liu

2021

Polymers

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Survey on endocrine-disrupting chemicals in seafood: Occurrence and distribution

Cunha

Menezes-Sousa

Mello

et al. 2022

Environmental Research

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Analysis of brominated flame retardants in the aquatic environment: a review

Jagić

Dvoršćak

Klinčić

2021

Archives of Industrial Hygiene and Toxicology

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The most common and consequently analysed brominated flame retardants (BFRs) are polybrominated biphenyls (PBBs), polybrominated diphenyl ethers (PBDEs), tetrabromobisphenol A (TBBPA), tetrabromobisphenol S (TBBPS), and hexabromocyclododecane (HBCD). As these persistent organic pollutants are widespread in the environment and have a number of harmful effects on human health, the production and use of most has been banned for several years. The aquatic environment is polluted by these compounds through their deposition from the atmosphere, sewage sludge, wastewater treatment plants, and landfills, and higher levels are found in areas with developed industry and agriculture and near landfills. Each compound also seems to show preference for specific compartments of the aquatic environment, i.e. water, sediment, or aquatic organisms, according to their physicochemical properties. The aim of this review was to take a closer look at the analysis of BFRs, as without reliable analysis we would not be able to determine their levels and distribution across the aquatic compartments and assess human exposure and health risks. Particularly worrying are the health risks associated with PBDEs in fish, whose levels generally exceed the permitted values.

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Brominated Flame Retardants in Edible Fishes from Three Gorges Reservoir, China

Cited by 4 publications

References 33 publications

Establishment of a CoMFA Model Based on the Combined Activity of Bioconcentration, Long-Range Transport, and Highest Infrared Signal Intensity and Molecular Design of Environmentally Friendly PBB Derivatives

Establishment of a CoMFA Model Based on the Combined Activity of Bioconcentration, Long-Range Transport, and Highest Infrared Signal Intensity and Molecular Design of Environmentally Friendly PBB Derivatives

Survey on endocrine-disrupting chemicals in seafood: Occurrence and distribution

Analysis of brominated flame retardants in the aquatic environment: a review

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