Bromelain, the enzyme complex of pineapple (Ananas comosus) and its clinical application. An update

Taussig, S J; Batkin, Stanley

doi:10.1016/0378-8741(88)90127-4

Cited by 218 publications

(158 citation statements)

References 17 publications

Supporting

Mentioning

148

Contrasting

Unclassified

Order By: Relevance

“…Bromelain is a natural mixture of proteolytic enzymes that is derived from pineapple stems and has been proposed be useful for therapy of immune-mediated diseases (1,2). Bromelain has been used either alone or in a multi-enzyme preparation, most commonly combined with trypsin and rutin, in multiple clinical trials in both humans and animals.…”

Section: Introductionmentioning

confidence: 99%

Bromelain treatment decreases neutrophil migration to sites of inflammation

Fitzhugh

Shan

Dewhirst

et al. 2008

Clinical Immunology

114

View full text Add to dashboard Cite

Bromelain, a mixture of proteases derived from pineapple stem, has been reported to have therapeutic benefits in a variety of inflammatory diseases, including murine inflammatory bowel disease. The purpose of this work was to understand potential mechanisms for this anti-inflammatory activity. Exposure to bromelain in vitro has been shown to remove a number of cell surface molecules that are vital to leukocyte trafficking, including CD128a/CXCR1 and CD128b/CXCR2 that serve as receptors for the neutrophil chemoattractant IL-8 and its murine homologues. We hypothesized that specific proteolytic removal of CD128 molecules by bromelain would inhibit neutrophil migration to IL-8 and thus decrease acute responses to inflammatory stimuli. Using an in vitro chemotaxis assay, we demonstrated a 40% reduction in migration of bromelain-vs. sham-treated human neutrophils in response to rhIL-8. Migration to the bacterial peptide analog fMLP was unaffected, indicating that bromelain does not induce a global defect in leukocyte migration. In vivo bromelain treatment generated a 50 -85% reduction in neutrophil migration in 3 different murine models of leukocyte migration into the inflamed peritoneal cavity. Intravital microscopy demonstrated that although in vivo bromelain treatment transiently decreased leukocyte rolling, its primary long-term effect was abrogation of firm adhesion of leukocytes to blood vessels at the site of inflammation. These changes in adhesion were correlated with rapid re-expression of the bromelain-sensitive CD62L/L-selectin molecules that mediate rolling following in vivo bromelain treatment and minimal re-expression of CD128 over the time period studied. Taken together, these studies demonstrate that bromelain can effectively decrease neutrophil migration to sites of acute inflammation and support the specific removal of the CD128 chemokine receptor as a potential mechanism of action.

show abstract

Section: Introductionmentioning

confidence: 99%

Bromelain treatment decreases neutrophil migration to sites of inflammation

Fitzhugh

Shan

Dewhirst

et al. 2008

Clinical Immunology

114

View full text Add to dashboard Cite

show abstract

“…Bromelain is a mixture of proteases. [13] Bromelain alters molecular pathways of carcinogenesis, tumor microenvironment hence could be used as an anticancer agent. Bromelain also exerts anticancer effects by immunomodulation and hemostatic mechanism.…”

Section: Allium Vegetablesmentioning

confidence: 99%

Evidence-based review on anticancer effects of commonly used herbs

Saranya¹,

Malathi²

2014

JCRI

View full text Add to dashboard Cite

Cancer, a disease with high morbidity and mortality rates, is a challenge to human life. The current therapeutic strategies are associated with adverse effects which necessitate alternate treatment with less adverse effects. In addition to this, cancer prevention is desirable which has led to a new concept called biochemoprevention. In this regard, medicinal properties of plants can be exploited for cancer prevention and management as they can be procured cost effectively and are less likely to produce adverse effects as they are diet derived. This article reviews the phytochemicals and evidence-based preventive and therapeutic effects of some commonly used plants with medicinal properties against cancer.

show abstract

“…Bromelain contains, among other compounds, various closely related thiol endopeptidases, exhibiting various fibrinolytic, antithrombotic, and anti-inflammatory activities in vitro and in vivo. Bromelain concentration is high in pineapple stem, thus necessitating its extraction, as the stem is a waste byproduct and thus inexpensive [22]. Bromelain can be absorbed in human intestines without degradation and without losing its biological activity [7].…”

Section: Introductionmentioning

confidence: 99%

Ameliorative potential of stem bromelain on lead-induced toxicity in Wistar rats

Al-Otaibi¹,

Virk²,

Elobeid³

2015

Acta Biologica Hungarica

View full text Add to dashboard Cite

The present study investigates the protective efficacy of stem bromelain against lead-induced toxicity in male Wistar rats. There were six experimental groups; Group I was negative control, Group II was administered only 20 mg/kg of stem bromelain. Group III and V were orally exposed to 30 mg/kg/day and 60 mg/kg/day of lead acetate, respectively. Group IV and Group VI were exposed to both low and high dose of lead acetate, respectively, and treated with 20 mg/kg stem bromelain. The experimental period was 21 days. The end points evaluated were, lead accumulation in kidney, liver and spleen, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activity, serum malonaldehyde (MDA) cholesterol and triglycerides levels. Co-administration of stem bromelain with lead markedly reduced the lead accumulation in the kidney and spleen. The treatment of stem bromelain also reduced the serum MDA levels in the group exposed to lower dose of lead and serum triglyceride level in the group exposed to higher dose of lead. The lead-induced modulated levels of serum ALT and AST were also alleviated by bromelain treatment. Our key findings suggest a chelating potential of stem bromelain for combating lead toxicity and oxidative stress. Bromelain represents a novel approach to the treatment of metal toxicity and metabolic disorders with a limited therapeutic window.

show abstract

Bromelain, the enzyme complex of pineapple (Ananas comosus) and its clinical application. An update

Cited by 218 publications

References 17 publications

Bromelain treatment decreases neutrophil migration to sites of inflammation

Bromelain treatment decreases neutrophil migration to sites of inflammation

Evidence-based review on anticancer effects of commonly used herbs

Ameliorative potential of stem bromelain on lead-induced toxicity in Wistar rats

Contact Info

Product

Resources

About