Bromelain’s penetration into the blood and sinonasal mucosa in patients with chronic rhinosinusitis

Passàli, Desiderio; Passàli, Giulio Cesare; Bellussi, Luisa; Sarafoleanu, Codruț; Loglisci, Michele; Manea, Claudiu; Iosif, Cristina; Passàli, Francesco Maria

doi:10.14639/0392-100x-1693

Cited by 21 publications

(29 citation statements)

References 9 publications

(9 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A decrease in the severity of pain, swelling, or signs of inflammation was observed. According to Passali et al [178], an appropriate bromelain's biological activity level may be due to its excellent distribution by diffusion from the blood to rhinosinusal mucosa.…”

Section: Chronic Rhinosinusitismentioning

confidence: 99%

Beneficial Properties of Bromelain

Hikisz

Bernasińska-Słomczewska

2021

Nutrients

View full text Add to dashboard Cite

Bromelain is a major sulfhydryl proteolytic enzyme found in pineapple plants, having multiple activities in many areas of medicine. Due to its low toxicity, high efficiency, high availability, and relative simplicity of acquisition, it is the object of inexhaustible interest of scientists. This review summarizes scientific reports concerning the possible application of bromelain in treating cardiovascular diseases, blood coagulation and fibrinolysis disorders, infectious diseases, inflammation-associated diseases, and many types of cancer. However, for the proper application of such multi-action activities of bromelain, further exploration of the mechanism of its action is needed. It is supposed that the anti-viral, anti-inflammatory, cardioprotective and anti-coagulatory activity of bromelain may become a complementary therapy for COVID-19 and post-COVID-19 patients. During the irrepressible spread of novel variants of the SARS-CoV-2 virus, such beneficial properties of this biomolecule might help prevent escalation and the progression of the COVID-19 disease.

show abstract

Section: Chronic Rhinosinusitismentioning

confidence: 99%

Beneficial Properties of Bromelain

Hikisz

Bernasińska-Słomczewska

2021

Nutrients

View full text Add to dashboard Cite

show abstract

“…Other extracts have been shown to possess activity against coronaviruses, mediated through inhibition of viral entry and/or replication, or through an as-yet unknown antiviral mechanism [ 67 ]. In the respiratory setting, bromelain has demonstrated good distribution to serum and rhinosinusal tissues when administered as a tablet in people with chronic rhinosinusitis showing relief of symptoms [ 68 , 69 ]. In children with acute sinusitis, bromelain was associated with a faster recovery from symptoms without side effects (except in one participant with a pineapple allergy) when compared with children receiving one of the combination therapies (bromelain + standard treatment) and children receiving standard treatments only [ 70 ].…”

Section: The Rationale For Enzyme Therapeuticsmentioning

confidence: 99%

Harnessing the Potential of Enzymes as Inhaled Therapeutics in Respiratory Tract Diseases: A Review of the Literature

Vanderstocken¹,

Woolf²,

Trigiante

et al. 2022

Biomedicines

View full text Add to dashboard Cite

Respiratory tract diseases (RTDs) are a global cause of mortality and affect patient well-being and quality of life. Specifically, there is a high unmet need concerning respiratory tract infections (RTIs) due to limitations of vaccines and increased antibiotic resistance. Enzyme therapeutics, and in particular plant-based enzymes, represent an underutilised resource in drug development warranting further attention. This literature review aims to summarise the current state of enzyme therapeutics in medical applications, with a focus on their potential to improve outcomes in RTDs, including RTIs. We used a narrative review approach, searching PubMed and clinicaltrials.gov with search terms including: enzyme therapeutics, enzyme therapy, inhaled therapeutics, botanical enzyme therapeutics, plant enzymes, and herbal extracts. Here, we discuss the advantages and challenges of enzyme therapeutics in the setting of RTDs and identify and describe several enzyme therapeutics currently used in the respiratory field. In addition, the review includes recent developments concerning enzyme therapies and plant enzymes in (pre-)clinical stages. The global coronavirus disease 2019 (COVID-19) pandemic has sparked development of several promising new enzyme therapeutics for use in the respiratory setting, and therefore, it is timely to provide a summary of recent developments, particularly as these therapeutics may also prove beneficial in other RTDs.

show abstract

“…In children, the most commonly aspirated foreign bodies are peanuts. Tooth aspiration is uncommon 1,3 . Most cases occur secondary to trauma, 4 so the aspiration of an exfoliated primary tooth is extremely rare, with only three cases described in the literature 2 .…”

Section: Figmentioning

confidence: 99%