Broken Pancreas, Broken Heart

Cheezum, Michael K.; Willis, Scott L.; Duffy, Sean; Moawad, Fouad J.; Horwhat, John D.; Huffer, Linda; Welch, Timothy

doi:10.1038/ajg.2009.520

Cited by 15 publications

(12 citation statements)

References 3 publications

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“…Traditionally, TCM is more common in post-menopausal women, and about 90% of diagnosed patients are women aged 61-76 years. 8 , 9 This phenomenon is hypothesized to be due to estrogen deficiency in the later years of life. Estrogen is cardioprotective through down-regulation of hypothalamicadrenal axis and stimulation of atrial natriuretic peptide and shock-protein-70.…”

Section: Discussionmentioning

confidence: 99%

“…All these factors strongly suggest a female preponderance of TCM and, consistent with the same, the 5 reported cases of pancreatitis-induced TCM are women older than 40 years. 2 , 4 , 9 , 11 , 12 …”

Section: Discussionmentioning

confidence: 99%

“… 3 This hypothesis is further strengthened by highlighting the role of other sympathetic overdrive states such as pheochromocytoma and subarachnoid haemorrhage in the causation of TCM. 3 , 4 , 9 , 12 Additionally, the distributive shock that develops with severe acute pancreatitis can cause transient myocardial dysfunction and microvascular hypoperfusion. This phenomenon has been well-described as the causative mechanism of acute decompensated heart failure in septic shock, but its role in acute pancreatitis is not well elucidated.…”

Section: Discussionmentioning

confidence: 99%

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Acute Pancreatitis-Induced Takotsubo Cardiomyopathy in an African American Male

Bruenjes

Vallabhajosyula

Vacek

et al. 2016

ACG Case Reports Journal

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Takotsubo cardiomyopathy (TCM) is triggered by multiple physical and psychological stressors and frequently mimics acute coronary syndrome. Acute pancreatitis as a trigger for TCM has rarely been reported. We report a 55-year-old African American man with hypertension and alcohol abuse history, who presented with epigastric and sub-sternal pain and electrocardiogram demonstrating ischemic changes. Laboratory parameters revealed elevated troponin-I, amylase, lipase, and metabolic acidosis. He was diagnosed with acute pancreatitis and ACS. Coronary angiogram was unrevealing for coronary atherosclerosis and he was managed conservatively for acute pancreatitis and heart failure from TCM.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Acute Pancreatitis-Induced Takotsubo Cardiomyopathy in an African American Male

Bruenjes

Vallabhajosyula

Vacek

et al. 2016

ACG Case Reports Journal

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“…Besides the causes of TCM presented above, also acute pancreatitis (via exaggeration of sympathetic stimulation that leads to transient myocardial dysfunction and microvascular hypoperfusion distributive shock) could act as a trigger for TCM. To date, only a few cases of acute pancreatitis induced TCM have been described [5][6][7]. We present, to the best of our knowledge, first case report of TCM resulting from the exacerbation of chronic pancreatitis.…”

Section: Introductionmentioning

confidence: 85%

Takotsubo cardiomyopathy resulting from exacerbation of chronic pancreatitis

2016

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Takotsubo cardiomyopathy (TCM) is a medical condition characterized by a transient left ventricular apical dysfunction with unknown etiology. The clinical presentation mimics acute myocardial syndrome in the absence of obstructive coronary artery disease. The association between acute pancreatitis and TCM, however, is rarely reported in the literature. To date, no cases of TCM resulting from the exacerbation of chronic pancreatitis have been described.

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“…This syndrome presents a diagnostic challenge, given the wide spectrum of responsible physiological stressors. Numerous cases of gastrointestinal diseases or procedures have been described including recurrent vomiting, achalasia, upper digestive tract bleeding, cholecystitis, pancreatitis, cancers, all acting as triggers [4][5][6][7][8][9][10], but to the best of our knowledge, this patient is the first reported case of gastritis-induced TCM in literature to date.…”

Section: Discussionmentioning

confidence: 99%

Acute gastritis‐induced Takotsubo's cardiomyopathy

Villablanca

Sukhal

Ansari

et al. 2013

Clinical Case Reports

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Key Clinical MessageA 50-year-old lady presented with epigastralgia, electrocardiogram (ECG) showed T-wave inversions and the echocardiogram low ejection fraction (EF) with apical ballooning. An esophagogastroduodenoscopy (EGD) revealed gastritis. She recovered with proton pump inhibitors treatment. This is the first case that describes gastritis-induced stress cardiomyopathy. Clinicians should be aware of Takotsubo's cardiomyopathy (TCM) as a possible complication of gastritis.

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Broken Pancreas, Broken Heart

Cited by 15 publications

References 3 publications

Acute Pancreatitis-Induced Takotsubo Cardiomyopathy in an African American Male

Acute Pancreatitis-Induced Takotsubo Cardiomyopathy in an African American Male

Takotsubo cardiomyopathy resulting from exacerbation of chronic pancreatitis

Acute gastritis‐induced Takotsubo's cardiomyopathy

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