Broiler chickens (Ross strain) lack insulin-responsive glucose transporter GLUT4 and have GLUT8 cDNA

Seki, Yoshinori; Sato, Kei; Kono, Tatsuyoshi; Abé, Hiroyuki; Akiba, Yukio

doi:10.1016/s0016-6480(03)00145-x

Cited by 111 publications

(69 citation statements)

References 39 publications

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“…To determine whether b-AR agonists influenced memory consolidation by metabolic mechanisms known to be involved in memory, the glycolysis inhibitor iodoacetate, the glycogenolysis inhibitor DAB, or the inhibitor of glucose metabolism 2-DG were administered into IMM at predetermined times prior to the different doses of agonists given subcutaneously. The expression patterns of GLUT-1 and GLUT-3 mRNA in chicken tissues are generally similar to those in mammals (Kono et al, 2005), but chickens have an insulin-sensitive GLUT-8 gene in place of the GLUT-4 gene found in mammals (Seki et al, 2003).…”

Section: Experimental Designmentioning

confidence: 75%

Role of β-Adrenoceptors in Memory Consolidation: β3-Adrenoceptors Act on Glucose Uptake and β2-Adrenoceptors on Glycogenolysis

Gibbs

Hutchinson

Summers

2007

Neuropsychopharmacol

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Noradrenaline, acting via b 2 -and b 3 -adrenoceptors (AR), enhances memory formation in single trial-discriminated avoidance learning in day-old chicks by mechanisms involving changes in metabolism of glucose and/or glycogen. Earlier studies of memory consolidation in chicks implicated b 3 -rather than b 2 -ARs in enhancement of memory consolidation by glucose, but did not elucidate whether stimulation of glucose uptake or of glycolysis was responsible. This study examines the role of glucose transport in memory formation using central injection of the nonselective facilitative glucose transporter (GLUT) inhibitor cytochalasin B, the endothelial/astrocytic GLUT-1 inhibitor phloretin and the Na + /energy-dependent endothelial glucose transporter (SGLT) inhibitor phlorizin. Cytochalasin B inhibited memory when injected into the mesopallium (avian cortex) either close to or between 25 and 45 min after training, whereas phloretin and phlorizin only inhibited memory at 30 min. This suggested that astrocytic/endothelial (GLUT-1) transport is critical at the time of consolidation, whereas a different transporter, probably the neuronal glucose transporter (GLUT-3), is important at the time of training. Inhibition of glucose transport by cytochalasin B, phloretin, or phlorizin also interfered with b 3 -AR-mediated memory enhancement 20 min posttraining, whereas inhibition of glycogenolysis interfered with b 2 -AR agonist enhancement of memory. We conclude that in astrocytes (1) activities of both GLUT-1 and SGLT are essential for memory consolidation 30 min posttraining; (2) neuronal GLUT-3 is essential at the time of training; and (3) b 2 -and b 3 -ARs consolidate memory by different mechanisms; b 3 -ARs stimulate central glucose transport, whereas b 2 -ARs stimulate central glycogenolysis.

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Section: Experimental Designmentioning

confidence: 75%

Role of β-Adrenoceptors in Memory Consolidation: β3-Adrenoceptors Act on Glucose Uptake and β2-Adrenoceptors on Glycogenolysis

Gibbs

Hutchinson

Summers

2007

Neuropsychopharmacol

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“…In addition, they show immunohistochemical evidence of protein expression of GLUT1 and GLUT3, as well as western blots showing the absence of GLUT4. Similarly, Seki et al report the absence of GLUT4 in broiler chickens (Seki et al, 2003). Sweazea and Braun argue that previous reports of GLUT4 in avian skeletal muscles are probably erroneous (Sweazea and Braun, 2006).…”

Section: Elements Of the Sugar Oxidation Cascadementioning

confidence: 96%

The sugar oxidation cascade: aerial refueling in hummingbirds and nectar bats

Suarez

Welch

2011

Journal of Experimental Biology

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SummaryMost hummingbirds and some species of nectar bats hover while feeding on floral nectar. While doing so, they achieve some of the highest mass-specific V O2 values among vertebrates. This is made possible by enhanced functional capacities of various elements of the 'O 2 transport cascade', the pathway of O 2 from the external environment to muscle mitochondria. Fasted hummingbirds and nectar bats fly with respiratory quotients (RQs; V CO2 /V O2 ) of ~0.7, indicating that fat fuels flight in the fasted state. During repeated hover-feeding on dietary sugar, RQ values progressively climb to ~1.0, indicating a shift from fat to carbohydrate oxidation. Stable carbon isotope experiments reveal that recently ingested sugar directly fuels ~80 and 95% of energy metabolism in hover-feeding nectar bats and hummingbirds, respectively. We name the pathway of carbon flux from flowers, through digestive and cardiovascular systems, muscle membranes and into mitochondria the 'sugar oxidation cascade'. O 2 and sugar oxidation cascades operate in parallel and converge in muscle mitochondria. Foraging behavior that favours the oxidation of dietary sugar avoids the inefficiency of synthesizing fat from sugar and breaking down fat to fuel foraging. Sugar oxidation yields a higher P/O ratio (ATP made per O atom consumed) than fat oxidation, thus requiring lower hovering V O2 per unit mass. We propose that dietary sugar is a premium fuel for flight in nectarivorous, flying animals.

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“…GLUT3 deficiency has been implicated in age of onset in Huntington's disease [24]. Chicken GLUT3 shares 70% sequence similarity with the human's [25,2] and is known to be a neuronal glucose transporter [25]. The neuronal functions of GLUT1 and GLUT3 are similar across chickens and mammals [17,18].…”

Section: Class I Glutsmentioning

confidence: 99%

“…According to the NCBI Gene Database, GLUT4/SLC2A4 orthologs are found in 114 organisms including dog, cow, chimpanzee, mouse, rat and Rhesus monkey. Chickens intrinsically lack GLUT4 expression, and chickens are known to be naturally hyperglycemic with adipose tissue that is poorly sensitive to insulin [2,29].…”

Section: Class I Glutsmentioning

confidence: 99%

Avian and Mammalian Facilitative Glucose Transporters

Byers¹,

Howard²,

Wang³

2017

Preprint

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Abstract:The GLUT members belong to a family of glucose transporter proteins that facilitate glucose transport across the cell membrane. The mammalian GLUT family consists of thirteen members (GLUTs 1-12 and HMIT). Humans have a recently duplicated GLUT member, GLUT14. Avians express the majority of GLUT members. The arrangement of multiple GLUTs across all somatic tissues signifies the important role of glucose across all organisms. Defects in glucose transport have been linked to metabolic disorders, insulin resistance and diabetes. Despite the essential importance of these transporters, our knowledge regarding GLUT members in avians is fragmented. It has been clear that there are no chicken orthologs of mammalian GLUT4 and GLUT7. Our examination of GLUT members in the chicken revealed that some chicken GLUT members do not have corresponding orthologs in mammals. We review the information regarding GLUT orthologs and their function and expression in mammals and birds, with emphasis on chickens and humans.

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Broiler chickens (Ross strain) lack insulin-responsive glucose transporter GLUT4 and have GLUT8 cDNA

Cited by 111 publications

References 39 publications

Role of β-Adrenoceptors in Memory Consolidation: β3-Adrenoceptors Act on Glucose Uptake and β2-Adrenoceptors on Glycogenolysis

Role of β-Adrenoceptors in Memory Consolidation: β3-Adrenoceptors Act on Glucose Uptake and β2-Adrenoceptors on Glycogenolysis

The sugar oxidation cascade: aerial refueling in hummingbirds and nectar bats

Avian and Mammalian Facilitative Glucose Transporters

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