Broca's area, sentence comprehension, and working memory: an fMRI study

Rogalsky, Corianne; Matchin, William; Hickok, Gregory

doi:10.3389/neuro.09.014.2008

Cited by 143 publications

(139 citation statements)

References 65 publications

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“…However, the left IFG was also found to be involved with semantic, syntactic, and phonological processes that are relevant to both the production and comprehension of speech (41). These processes include semantic retrieval (60), lexical decision (61), syntactic transformations (62,63), and verbal working memory (64)(65)(66)(67)(68)(69). Based on such reports it was argued that the left IFG is involved with both production and comprehension processes (21,70,71).…”

Section: Discussionmentioning

confidence: 99%

Coupled neural systems underlie the production and comprehension of naturalistic narrative speech

Silbert

Honey

Simony

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

320

246

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Neuroimaging studies of language have typically focused on either production or comprehension of single speech utterances such as syllables, words, or sentences. In this study we used a new approach to functional MRI acquisition and analysis to characterize the neural responses during production and comprehension of complex real-life speech. First, using a time-warp based intrasubject correlation method, we identified all areas that are reliably activated in the brains of speakers telling a 15-min-long narrative. Next, we identified areas that are reliably activated in the brains of listeners as they comprehended that same narrative. This allowed us to identify networks of brain regions specific to production and comprehension, as well as those that are shared between the two processes. The results indicate that production of a real-life narrative is not localized to the left hemisphere but recruits an extensive bilateral network, which overlaps extensively with the comprehension system. Moreover, by directly comparing the neural activity time courses during production and comprehension of the same narrative we were able to identify not only the spatial overlap of activity but also areas in which the neural activity is coupled across the speaker's and listener's brains during production and comprehension of the same narrative. We demonstrate widespread bilateral coupling between production-and comprehension-related processing within both linguistic and nonlinguistic areas, exposing the surprising extent of shared processes across the two systems.speech production | speech comprehension | intersubject correlation | brain-to-brain coupling S uccessful verbal communication requires the finely orchestrated interaction between production-based processes in the speaker's brain and comprehension-based processes in the listener's brain. The extent of brain areas involved in the production of real-world speech in a speaker's brain during naturalistic communication is largely unknown. As a result, the degree of overlap between the production and comprehension systems, and the ways in which they interact, remain controversial. This study pursues three aims: (i) to map all areas (including but not limited to sensory, motoric, linguistic, and extralinguistic) that are reliably activated during the production of complex, real-world narrative; (ii) to map the overlap between areas that respond reliably during the production and the comprehension of real-world narrative; and (iii) to assess the coupling between activity in the speaker's brain during naturalistic production and activity in the listener's brain during comprehension of the same narrative. We discuss each challenge in turn.The functional-anatomic architecture underlying the production of speech in an ecological context is incompletely characterized. Studies investigating production-based brain activity have been mainly restricted to the production of single phonemes (1-5), words (6-8), or short phrases in decontextualized, isolated environments (9-13) (see refs. 14...

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Section: Discussionmentioning

confidence: 99%

Coupled neural systems underlie the production and comprehension of naturalistic narrative speech

Silbert

Honey

Simony

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

320

246

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“…In our study, area BA44 in the PreG responded strongly right lateralized. The role of the left BA44 corresponding to the Broca's area (covering the pars triangularis and pars opercularis) as a syntactic processor or as a WM resource in sentence comprehension has been debated over the last 30 years and remains controversial (Rogalsky, Matchin, & Hickok, 2008). In the context of music, fMRI studies (Koelsch & Siebel, 2005) using chord sequence and melody paradigms have linked music syntactic processing with a predominantly right activation in the pars opercularis.…”

Section: Neuroanatomy Of Working Memory For Musicmentioning

confidence: 99%

Dynamics of brain activity underlying working memory for music in a naturalistic condition

Burunat

Alluri

Toiviainen

et al. 2014

Cortex

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Sivumäärä -Number of pages 70Tiivistelmä -Abstract Working memory (WM) is at the core of any cognitive function as it is necessary for the integration of information over time. Despite WM's critical role in high-level cognitive functions, its implementation in the neural tissue is poorly understood. Preliminary studies on auditory WM show differences between linguistic and musical memory, leading to the speculation of specific neural networks encoding memory for music. Moreover, in neuroscience WM has not been studied in naturalistic listening conditions but rather in artificial settings (e.g., n-back and Sternberg tasks). Western tonal music provides naturally occurring motivic repetition and variation, recognizable units serving as WM trigger, thus allowing us to study the phenomenon of motif-tracking in the context of real music. Adopting a modern tango as stimulus, behavioural methods were used to identify the stimulus motifs and build a time-course predictor of WM neural responses. This predictor was then correlated with the participants' functional magnetic resonance imaging (fMRI) signal obtained during a continuous listening condition. Neural correlates related to the sensory processing of a set of musical features were filtered out from the brain responses to music to aid in the exclusive recruitment of executive processes of music-related WM. Correlational analysis revealed a widely distributed network of cortical and subcortical areas, predominantly right-lateralized, responding to the WM condition, including ventral and dorsal areas in the prefrontal cortex, basal ganglia, and limbic areas. Significant subcortical processing areas, active in response to the WM condition, were pruned with the removal of the acoustic content, suggesting these music-related perceptual processing areas might aid in the encoding and retrieval of WM. The pattern of dispersed neural activity indicates WM to emerge coherently from the integration of distributed neural activity spread out over different brain subsystems (motoric-, cognitive-and sensory-related areas of the brain).Asiasanat -Keywords working memory; cognitive neuroscience; music; musical motifs; functional magnetic resonance imaging ( Lashley was attempting to identify the locus of memory within the cortex, and, to do so, first trained rats to run mazes, and then removed various cortical regions. He allowed the animals to recover and tested the retention of the maze-running skills. To his surprise it was not possible to find a particular region corresponding to the ability to remember the way through a maze. Instead all the rats which had had cortex regions removed suffered some kind of impairment, and the extent of the impairment was roughly proportional to the amount of cortex taken off. Removing cortex damaged the motor and sensory capacities of the animals, and they would limp, hop, roll, or stagger, but somehow they always managed to traverse the maze. So far as memory 'as concerned, the cortex appeared to be equipotential, that is, with all regions of eq...

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“…Strong activity in Broca's area arises in conditions demanding semantic control (Whitney, Kirk, O'Sullivan, Lambon Ralph & Jefferies, 2011), effort (Wallentin, Roepstorff, Glover & Burgess, 2006), task difficulty (Binder, Desai, Graves & Conant, 2009;Ruff, Blumstein, Myers & Hutchison, 2008), working memory (Rogalsky & Hickok, 2011;Rogalsky, Matchin & Hickok, 2008), and semantic integration (Rappaport Hovav, Doron & Sichel, 2010). Interestingly, whereas previous works have reported this differential activity during the processing of linguistic structures, current data show differential activity in Broca's area after the processing of linguistic structures, during the processing of visual animations.…”

Section: Discussionmentioning

confidence: 99%

Broca's Area Activity in the Lexical Semantics of Visual Causal Events

Limongi

Habib

Young

et al. 2016

RLA

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From a cognitive linguistics perspective, is assessed the effects of causative constructions on the activity of Broca's area during the processing of visual causal and non-causal events. Lexical causatives (e.g., the orange ball moves the purple ball) describe only direct causal events whereas periphrastic causatives (e.g., the orange ball causes the purple ball to move) describe both direct and indirect causal events. Based on this difference, is used lexical and periphrastic causatives as verbal instructions that directed participants to judge billiards balls collisions depicting direct, indirect, and non-causal events. By using functional magnetic resonance imaging (fMRI) and region of interest analysis, is found that judgments of all three visual events more strongly activated Broca's area following the periphrastic instruction than following the lexical instruction, and judgments of direct events produced stronger activity in Broca's area than indirect events. Interestingly, causal judgments were segregated between pars opercularis and pars triangularis. Results are discussed within the context of the linguistic category priming hypothesis, linear ballistic accumulator models, and the hierarchical organization of the prefrontal cortex. Because this our data suggest functional segregation during causal judgments, it is proposed that 44 RLA. Revista de Lingüística Teórica y Aplicada, 54 (2), II Sem. 2016 effective connectivity between these regions is worth evaluating in a follow-up study via dynamic causal modeling of fMRI data.Keywords: Causal judgment; causal conceptualization; lexical causatives; periphrastic causatives; Broca's area. RESuMENDesde una perspectiva de la lingüística cognitiva, se evalúa los efectos de las construcciones causativas en la actividad del área de Broca durante el procesamiento de eventos visuales causales y no causales. Las estructuras léxicas causativas (e.g., la bola anaranjada mueve a la bola púrpura) describen solamente eventos causales directos mientras que las estructuras perifrásticas causativas (e.g., la bola anaranjada hace mover a la bola púrpura) describen tanto los eventos directos como los indirectos. Basados en esta diferencia, se emplea estructuras causativas léxicas y perifrásticas como instrucciones verbales que dirigían a los participantes a juzgar si colisiones del tipo "bolas de billar" simulaban eventos causales directos, causales indirectos y no causales. Mediante el uso de resonancia magnética nuclear funcional (RMNf ) y el análisis por región de interés se encontró que los juicios sobre los tres tipos de eventos activaron más la región de Broca cuando eran precedidos por la instrucción perifrástica que cuando eran precedidos por la instrucción léxica. Por otra parte, los juicios sobre los eventos directos producían mayor actividad en el área de Broca que los eventos indirectos. Se encontró interesante que los juicios causales estuvieron asociados a actividad segregada en el pars opercularis y en el pars triangularis. Los resultados son discutid...

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Broca's area, sentence comprehension, and working memory: an fMRI study

Cited by 143 publications

References 65 publications

Coupled neural systems underlie the production and comprehension of naturalistic narrative speech

Coupled neural systems underlie the production and comprehension of naturalistic narrative speech

Dynamics of brain activity underlying working memory for music in a naturalistic condition

Broca's Area Activity in the Lexical Semantics of Visual Causal Events

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