2021
DOI: 10.1038/s41586-021-04356-8
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Broadly neutralizing antibodies target a haemagglutinin anchor epitope

Abstract: Broadly neutralizing antibodies that target epitopes of haemagglutinin on the influenza virus have the potential to provide near universal protection against influenza virus infection1. However, viral mutants that escape broadly neutralizing antibodies have been reported2,3. The identification of broadly neutralizing antibody classes that can neutralize viral escape mutants is critical for universal influenza virus vaccine design. Here we report a distinct class of broadly neutralizing antibodies that target a… Show more

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Cited by 92 publications
(111 citation statements)
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“…consistent VDJ gene identification) and enough donor information to distinguish bona fide recurrence from clonal expansion within given individuals. Generation of such truth data at scale is feasible using existing methods 21,[38][39][40][41] .…”
Section: Discussionmentioning
confidence: 99%
See 3 more Smart Citations
“…consistent VDJ gene identification) and enough donor information to distinguish bona fide recurrence from clonal expansion within given individuals. Generation of such truth data at scale is feasible using existing methods 21,[38][39][40][41] .…”
Section: Discussionmentioning
confidence: 99%
“…A clonotype can therefore be treated as the minimal functional group of antibodies. Next, as has been observed, nature repeats itself by creating similar clonotypes that appear to have the same function 2-21 , and these might be combined into groups. Such recurrences have been observed between donors, but also occur within single donors, as we will demonstrate.…”
Section: A Novel Approach To Grouping Antibodies Reveals Light Chain ...mentioning
confidence: 92%
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“…Many factors contribute to the paucity of broadly neutralizing influenza antibodies, including steric hindrance and molecular constraints caused by the proximity of some conserved epitopes to the viral membrane (Angeletti and Yewdell, 2018b;Guthmiller et al, 2021;Krammer, 2016;Lee and Wilson, 2015). A prevailing hypothesis was that B cells with high-affinity receptors specific for the variable epitopes outcompete B cells specific for conserved HA epitopes in germinal centers (Angeletti and Yewdell, 2018a).…”
Section: Introductionmentioning
confidence: 99%