Broadly conserved FlgV controls flagellar assembly andBorrelia burgdorferidissemination in mice
Maxime Zamba-Campero,
Daniel Soliman,
Huaxin Yu
et al.
Abstract:Flagella propel pathogens through their environments yet are expensive to synthesize and are immunogenic. Thus, complex hierarchical regulatory networks control flagellar gene expression. Spirochetes are highly motile bacteria, but peculiarly in the Lyme spirochete Borrelia burgdorferi, the archetypal flagellar regulator σ28 is absent. We rediscovered gene bb0268 in B. burgdorferi as flgV, a broadly-conserved gene in the flagellar superoperon alongside σ28 in many Spirochaetes, Firmicutes and other phyla, with… Show more
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