on colorectal cancer screening describes the concerning disproportionate burden of colorectal cancer experienced by Black, American Indian, and Alaska Native adults.In reviewing the evidence on colorectal cancer screening, we found that the primary drivers for the health disparity in Black adults were likely inequities in access, utilization, and quality of colorectal cancer screening and treatment rather than any genetic differences. 2,3 We call on clinicians to ensure that all patients, especially those disproportionately affected by colorectal cancer, get effective screening tests. To facilitate this aim, the USPSTF describes several different screening modalities that we found to reduce colorectal cancer morbidity and mortality effectively. 4 For the USPSTF to recommend a screening test, there must be evidence showing that using the screening test improves health outcomes, such as decreasing deaths from colorectal cancer. Ideally, this proof would come from clinical trials showing decreased colorectal cancer deaths when screened participants are compared with unscreened participants, as has been demonstrated with flexible sigmoidoscopy and guaiac fecal occult blood tests (gFOBTs). If that evidence is not available, the USPSTF then examines whether there is enough evidence that a screening test can accurately detect disease early compared with a colonoscopy reference standard and whether treatment of that screening-detected disease improves health outcomes. The USPSTF found this evidence for other stool tests and direct visualization tests. 4 However, the accuracy of a screening test alone is insufficient evidence for the USPSTF to recommend it. Furthermore, there is a potential concern that recommending a test that has limited evidence of proven benefit may actually widen rather than minimize disparities if that test is more likely to be used in a medically underserved population. As more evidence becomes available on newer screening tests, the USPSTF looks forward to evaluating that evidence to help improve the health of all people living in the US and address health inequities. In the meantime, there are several screening tests and modalities the USPSTF has found to be effective, including direct visualization tests (such as colonoscopy, flexible sigmoidoscopy, and computed tomography colonography) and stool-based tests (such as high-sensitivity gFOBT, FIT, and stool DNA test with FIT).The USPSTF recommendation statement provides information about the specific characteristics of each test that may make it easier or harder for a given individual to complete screening. 4 We encourage clinicians to discuss these tests with patients to help them choose the best option for each individual. The USPSTF believes the best test among these evidence-based options is the one that a patient chooses and will complete.