Broadband ultraviolet <scp>A</scp> in the treatment of psoriasis vulgaris: a randomized controlled trial

El‐Mofty, Medhat; Mostafa, Wedad Z.; Yousef, Randa; Abdel‐Halim, Mona R. E.; Hawary, Marwa El; Kader, Hanaa Abdel; Assaad, Soheir; Ghannam, Bahaa Bedair

doi:10.1111/ijd.12317

Int J Dermatology

2014

DOI: 10.1111/ijd.12317

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Broadband ultraviolet A in the treatment of psoriasis vulgaris: a randomized controlled trial

Medhat El‐Mofty¹,

Wedad Z. Mostafa²,

Randa Yousef³

et al.

Abstract: BB-UVA appears to be safe and acceptable for the treatment of chronic plaque psoriasis possibly through bcl-2-mediated apoptosis of keratinocytes and epidermal lymphocytes.

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Cited by 4 publications

References 15 publications

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UVA1 vs. narrowband UVB phototherapy in the treatment of palmoplantar pustulosis: a pilot randomized controlled study

Ren

Cheng

et al. 2017

Lasers Med Sci

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UVA1 phototherapy, a new therapeutic approach, has recently been shown good efficacy in the treatment of palmoplantar pustulosis (PPP). The purpose of this study was to compare the efficacy of UVA1 and narrowband UVB (NB-UVB) therapy in the treatment of PPP. Patients with PPP were randomly assigned to either UVA1 or NB-UVB therapy according to a left-right randomization table. Both treatments were performed three times weekly for up to 30 sessions. Clinical evaluation was based on the Palmoplantar Pustular Psoriasis Area and Severity Index (PPPASI) score. Totally 64 patients completed the study. Both UVA1 and NB-UVB therapy showed a statistically significant reduction of PPPASI score compared with the baseline value at the end of the treatment period (P < 0.05). There was a significantly greater mean reduction of PPPASI score in the UVA1 treated group when compared to the NB-UVB treated patients at 30 sessions (6.0 ± 2.4 vs. 4.4 ± 1.4, P < 0.05). No phototoxic reaction or bullous changes were observed in either group. Both NB-UVB and UVA1 phototherapy of PPP resulted in significant improvement. UVA1 phototherapy was more effective than NB-UVB irradiation in the treatment of PPP.

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UVA1 vs. narrowband UVB phototherapy in the treatment of palmoplantar pustulosis: a pilot randomized controlled study

Ren

Cheng

et al. 2017

Lasers Med Sci

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Efficacy assessment of UVA1 and narrowband UVB for treatment of scalp psoriasis

et al. 2018

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To compare the efficacy and safety of UVA1 and narrowband UVB (NB-UVB) therapy in the treatment of scalp psoriasis. Patients with scalp psoriasis were randomly assigned to either UVA1 or NB-UVB therapy. Both treatments were performed three times weekly for 6 weeks. Clinical efficacy was evaluated by using Psoriasis Scalp Severity Index (PSSI), and patient-reported quality of life (QoL) was assessed by Dermatology Life Quality Index (DLQI). Totally 68 patients completed the study. Both UVA1 and NB-UVB phototherapy achieved a statistically significant reduction of PSSI and DLQI scores at the end of the treatment period. Compared with the NB-UVB group, the significantly greater improvements occurred in UVA1 treatment group at week 3, although differences declined thereafter through week 10. Both UVA1 and NB-UVB therapy were well-tolerated in this study, and the occurrence of adverse events (AEs) was uncommon. Both UVA1 and NB-UVB phototherapy could offer relief of scalp symptoms in patients with scalp involvement. Furthermore, UVA1 treatment could improve the clinical manifestations and QoL more quickly than NB-UVB therapy.

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A Review and Update of Phototherapy Treatment Options for Psoriasis

2018

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Broadband ultraviolet A in the treatment of psoriasis vulgaris: a randomized controlled trial

Abstract: BB-UVA appears to be safe and acceptable for the treatment of chronic plaque psoriasis possibly through bcl-2-mediated apoptosis of keratinocytes and epidermal lymphocytes.

Cited by 4 publications

References 15 publications

UVA1 vs. narrowband UVB phototherapy in the treatment of palmoplantar pustulosis: a pilot randomized controlled study

UVA1 vs. narrowband UVB phototherapy in the treatment of palmoplantar pustulosis: a pilot randomized controlled study

Efficacy assessment of UVA1 and narrowband UVB for treatment of scalp psoriasis

A Review and Update of Phototherapy Treatment Options for Psoriasis

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