“…The aim of the present work is to explore the aptness of CPG fibers to perform time-domain broadband diffuse optical spectroscopy (TD-DOS) deep into biological tissues. Since TD-DOS can provide absolute estimate of the absorption and reduced scattering spectra of the diffusive medium [19,20], it conveys information on the chemical composition (mainly water, oxy-and deoxy-hemoglobin, water, lipids, collagen), on the functional status (e. g. oxygenation) and on the scattering properties (changes in tissue microstructure, edema) [21]. Such information can then be related to the tissue regeneration, to the healing process or to a harmful evolution.…”