Broad Tissue and Cell Tropism of Avian Bornavirus in Parrots with Proventricular Dilatation Disease

Rinder, Monika; Ackermann, Andreas; Kempf, Hermann; Kaspers, Bernd; Korbel, Rüdiger; Staeheli, Peter

doi:10.1128/jvi.00133-09

Cited by 103 publications

(153 citation statements)

References 30 publications

(51 reference statements)

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“…The N/X intergenic region of the two CG bornaviruses was 54 nt long, with an 8-amino-acid-encoding uORF whose termination codon overlaps the X start codon, as does the BDV uORF. As reported previously, the N-X intergenic region of psittacine ABVs is 27 nt long and lacks the BDV regulatory uORF (11,16).…”

mentioning

confidence: 79%

Detection and Characterization of a Distinct Bornavirus Lineage from Healthy Canada Geese (Branta canadensis)

Payne

Covaleda

Guo

et al. 2011

J Virol

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mentioning

confidence: 79%

Detection and Characterization of a Distinct Bornavirus Lineage from Healthy Canada Geese (Branta canadensis)

Payne

Covaleda

Guo

et al. 2011

J Virol

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“…Multiple researchers have described the presence of ABV within the kidney, in Dovepress submit your manuscript | www.dovepress.com PDD-affected and ABV-infected birds via PCR and immunohistochemical staining. 4,5,9 Indeed, some have postulated that ABV may be transmitted via the kidney or urine. 5 Avian droppings consist of a mixture of feces and urine.…”

Section: Introductionmentioning

confidence: 99%

Avian bornavirus in the urine of infected birds

Heatley

Villalobos²

2012

VMRR

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Avian bornavirus (ABV) causes proventricular dilatation disease in multiple avian species. In severe clinical disease, the virus, while primarily neurotropic, can be detected in many organs, including the kidneys. We postulated that ABV could be shed by the kidneys and found in the urine of infected birds. Immunohistochemical staining demonstrated viral N and P proteins of ABV within the renal tubules. We adapted a nonsurgical method of urine collection for use in parrots known to be shedding ABV in their droppings. We obtained urine without feces, and results were compared with swabs of fresh voided feces. Reverse transcription-polymerase chain reaction assay performed on these paired samples from five birds indicated that ABV was shed in quantity in the urine of infected birds, and a single sample was urine-positive and fecal-negative. We suggest that urine sampling may be a superior sample for detection of birds shedding ABV, and advocate that additional birds, known to be shedding or infected with ABV, should be investigated via this method.

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“…However, a recent report also documented the same result in the cerebrum [12], and the reason for these results is unknown. Little is known about the mode of transmission of ABV, including this reported case, but previous studies have suggested horizontal transmission of the virus via oral and/or respiratory routes [13]. A recent report of a PDD outbreak by ABV transmission between two breeder aviaries [8] as well as the presence of healthy or subclinical carriers of ABV in several species [9] suggests that ABV is highly transmissible among psittacines and other avian species.…”

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confidence: 93%

Proventricular Dilatation Disease Associated with Avian Bornavirus Infection in a Citron-Crested Cockatoo that Was Born and Hand-Reared in Japan

Ogawa

Sanada²,

Sanada³

et al. 2011

The Journal of Veterinary Medical Science

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ABSTRACT. A 5-month-old female Citron-crested Cockatoo (Cacatua sulphurea citrinocristata) that was born and hand-reared in Japan died with suspected proventricular dilatation disease (PDD). Macroscopic and microscopic examinations of the bird revealed characteristic features of PDD, i.e., distention of the proventriculus and infiltration of lymphocytes and plasma cells in ganglia of various organs and in central and peripheral nerves. A linkage of this PDD case to infection with avian bornavirus (ABV) was documented by RT-PCR amplification of the virus genomes from the affected bird. Phylogenetic analysis revealed that the ABV identified in this study clustered into the genotype 2, which is one of the dominant ABV genotypes worldwide. To the best of our knowledge, this is the first report of a natural case of PDD associated with ABV infection in Japan.

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Broad Tissue and Cell Tropism of Avian Bornavirus in Parrots with Proventricular Dilatation Disease

Cited by 103 publications

References 30 publications

Detection and Characterization of a Distinct Bornavirus Lineage from Healthy Canada Geese (Branta canadensis)

Detection and Characterization of a Distinct Bornavirus Lineage from Healthy Canada Geese (Branta canadensis)

Avian bornavirus in the urine of infected birds

Proventricular Dilatation Disease Associated with Avian Bornavirus Infection in a Citron-Crested Cockatoo that Was Born and Hand-Reared in Japan

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