Broad Spectrum of Leukoderma Acquisitum Centrifugum

Kopf, Alfred W.; Morrill, Sonia D.; Silberberg, Inga

doi:10.1001/archderm.1965.01600130020003

Cited by 114 publications

(58 citation statements)

References 27 publications

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“…Halo nevi can be solitary or involve multiple lesions. Multiple lesions occur in 20–50% of patients [2,17,18]; however, 90 lesions have been reported in a single patient [18]. In this study, 60% of patients demonstrated a solitary lesion, and 40% had more than two.…”

Section: Discussionmentioning

confidence: 56%

“…In this study, 60% of patients demonstrated a solitary lesion, and 40% had more than two. Halo nevi can occur on any region of the body, but are most common on the skin of the trunk, especially the back [2,19,20,21]. However, in our study, the most common site was the face (40%) followed by the back (17%), probably because the lesions on the face are easily seen, and urged the patients to seek treatment.…”

Section: Discussionmentioning

confidence: 62%

“…The lesion most commonly associated with halo nevi was vitiligo. Vitiligo was previously reported to be involved in 18–26% of patients [2,23,24]; similarly, Ortonne et al [25] stated that 20% of vitiligo patients demonstrated halo nevi. In this study, 2 cases (6.7%) were associated with vitiligo.…”

Section: Discussionmentioning

confidence: 97%

“…Acquired melanocytic nevus is the most common type of nevus surrounded by a hypopigmented halo. Other lesions with a surrounding hypopigmented zone include congenital nevus, dysplastic nevus, blue nevus, Spitz nevus, seborrheic keratosis, verruca plana, histiocytoma, malignant melanoma, basal cell carcinoma and neurofibroma [2,3]. Large-scale studies of its clinical characteristics and progress are scarce, both nationwide and internationally.…”

Section: Introductionmentioning

confidence: 99%

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Foxp3<sup>+</sup> Regulatory T Cells Are Increased in the Early Stages of Halo Nevi: Clinicopathological Features of 30 Halo Nevi

Park¹,

Jin²,

Choi³

et al. 2012

Dermatology

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Background: There have been few clinical studies of the role of regulatory T cells (Tregs) in halo formation of halo nevus. Objective: To evaluate the clinicopathologic features and the presence of Tregs in halo nevi. Methods: We analyzed 30 halo nevi and performed immunohistochemical analysis using antibodies against CD4, CD8, CD25 and Foxp3. We also performed double immunohistochemical staining for Foxp3 and CD25. Results: We found significant increases in Foxp3⁺ Tregs, and the shorter the halo nevus duration, the more Foxp3⁺ Tregs were detected. Also, the ratio of Foxp3 to CD8 T cells was increased in early stages of halo nevi. Double immunohistochemical staining suggested that the Tregs in the halo nevi were CD25⁺Foxp3⁺ T cells. Conclusions: Foxp3⁺ Tregs were greatly increased in the halo nevi. The shorter the halo nevi duration, the more Foxp3⁺ Tregs were involved in the earlier developmental stages of halo nevi.

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Section: Discussionmentioning

confidence: 56%

Section: Discussionmentioning

confidence: 62%

Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

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Foxp3<sup>+</sup> Regulatory T Cells Are Increased in the Early Stages of Halo Nevi: Clinicopathological Features of 30 Halo Nevi

Park¹,

Jin²,

Choi³

et al. 2012

Dermatology

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“…Kopf (15) reported incon sistent results with 0.5 percent colchicine ointment in the treatment of basal cell epitheliomas.…”

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confidence: 99%

Topical Antimetabolites

Zackheim¹,

Farber²

1970

Annu. Rev. Med.

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A major advance in dermatologic therapy in the past decade is the suc cessful use of cytotoxic agents by topical application in the treatment of early stages of certain cutaneous malignancies. These include solar keratoses (precursors of squamous cell carcinoma), intraepidermal carcinoma (Bow en's disease), superficial basal cell epithelioma, and early stages of the cu taneous lymphoma, mycosis fungoides. Also responsive to these agents are some virus infections of the skin as herpes simplex, and certain types of warts.5-Fluorouracil (5-FU) is probably the most widely used topical anti metabolite in the treatment of cutaneous precancers. It is a pyrimidine antagonist and alters cell function by inhibiting RNA, and, more important, DNA synthesis. Palliative effects have been produced by 5-FU in a number of human cancers including breast, stomach, large intestine, cervix, and ovary. Falkson & Schultz (1) noted disappearance of solar keratoses in pa tients receiving systemic 5-FU for advanced cancers.The first report of the successful use of topical 5-FU in cutaneous malig nancies was that of Klein et al. (2) who described necrosis of cutaneous me tastases from adenocarcinoma of the colon in two patients following the application of 20 percent 5-FU in a. hydrophilic base. In a subsequent com munication, Klein and co-workers (3) reported the involution of a lesion of keratoacanthoma with a 20 percent 5-FU ointment without damaging the surrounding skin. Injection of a 5 percent solution of 5-FU at the base of other keratoacanthomas also caused destruction of the tumors.In 1963, Dillaha and collaborators (4) reported excellent results in the treatment of extensive actinic keratoses on the face and neck with 20 percent 5-FU in hydrophilic ointment. Eighteen patients were treated with this preparation twice daily. In two to three days an inflammatory reaction was noted at the site of the keratoses without much change in the surrounding skin. The reaction reached its height in about two weeks at which time the medication was stopped. Healing of the lesions occurred in about two more 1 This study on Topical Antimetabolites was supported by a grant from the Hart ford Foundation. 59 Annu. Rev. Med. 1970.21:59-66. Downloaded from www.annualreviews.org Access provided by University of California -San Diego on 02/03/15. For personal use only. Quick links to online content Further ANNUAL REVIEWS

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Dermoscopy Patterns of Halo Nevi

Kolm¹,

Stefani²,

Hofmann‐Wellenhof³

et al. 2006

Arch Dermatol

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Background: Halo nevi (HN) are benign melanocytic nevi surrounded by a depigmented area (halo). This study aims to evaluate the dermoscopic features of HN and their changes during digital dermoscopic follow-up and to investigate the frequency of the halo phenomenon in a series of melanomas. Observations: In a retrospective study, digital dermoscopic images of HN from patients who attended the Pigmented Skin Lesions Clinic of the Department of Dermatology, Medical University of Graz, between October 1, 1997, and March 31, 2004, were reviewed and classified by dermoscopic morphologic criteria. For HN that were followed up with digital dermoscopy, the percentages of changes in the size of the nevus and halo components were calculated. In addition, digital dermoscopic images of histopathologically confirmed melanomas obtained from the same database were reviewed for the presence of an encircling halolike depigmentation. We classified 138 HN in 87 patients (mean age, 22.4 years). The most common dermoscopic structures were the globular and/or homogeneous patterns in more than 80% of HN. Follow-up of 33 HN revealed considerable size reduction of the nevus component, but this was not associated with significant structural changes. Of a total of 475 melanomas, only 2 revealed an encircling halo, but both displayed clear-cut melanoma-specific patterns according to dermoscopy. Conclusions: Halo nevi exhibit the characteristic dermoscopic features of benign melanocytic nevi, represented by globular and/or homogeneous patterns that are typically observed in children and young adults. Halo nevi reveal considerable changes of area over time during digital dermoscopic follow-up, albeit their structural patterns remain unchanged. For this reason and because melanoma with halolike depigmentation, despite being rare, additionally exhibits melanoma-specific dermoscopic criteria, the role of digital dermoscopic follow-up in the diagnosis of HN is insignificant.

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Broad Spectrum of Leukoderma Acquisitum Centrifugum

Cited by 114 publications

References 27 publications

Foxp3<sup>+</sup> Regulatory T Cells Are Increased in the Early Stages of Halo Nevi: Clinicopathological Features of 30 Halo Nevi

Foxp3<sup>+</sup> Regulatory T Cells Are Increased in the Early Stages of Halo Nevi: Clinicopathological Features of 30 Halo Nevi

Topical Antimetabolites

Dermoscopy Patterns of Halo Nevi

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