Abstract:25FcMBL, an engineered version of the blood opsonin mannose-binding 26 lectin (MBL) that contains the carbohydrate recognition domain (CRD) and27 flexible neck regions of MBL fused to the Fc portion of human IgG1, has been 28 shown to bind various microbes and pathogen-associated molecular patterns 29 (PAMPs). FcMBL also has been used to create an enzyme-linked lectin sorbent 30 assay (ELLecSA) for use as a rapid ( 1 hr) diagnostic of bloodstream infections.31 Here we extended this work by using the ELLecSA t… Show more
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