Broad-Spectrum Antibiotic Use in the First Six Months of Life Increases Risk for Pediatric Atopic Asthma

Does Antibiotic Exposure During Infancy Lead to Development of Asthma?

“…Our initial search identified 2,056 titles, of which 2,042 were excluded because they either did not investigate an association between antibiotic exposure and childhood asthma or were not in English. Of the 14 remaining articles, we excluded one study 17 18 that only examined prenatal antibiotic exposure, three studies that investigated exposures at either Ͻ 1 year of age 19 or Ͼ 1 year of age, 20,21 and one study 22 in which a discrete diagnosis of asthma was not reported as an outcome. As such, eight articles [23][24][25][26][27][28][29][30] met our inclusion criteria (Table 1); half were prospective, and the other half were retrospective.…”