Broad spectrum anti-RNA virus activities of titanium and vanadium substituted polyoxotungstates

Shigeta, S.; Mori, Shuichi; Kodama, Eiichi; Kodama, Junko; Takahashi, Kazuo; Yamase, Toshihiro

doi:10.1016/s0166-3542(03)00009-3

Cited by 121 publications

(77 citation statements)

References 20 publications

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“…Heteropolyoxotungstoantimonate is an effective agent against murine leukemia sarcoma virus, rabies virus and Epslein-Barr virus at very low dose rates [24,25]. In vivo studies show that V(V)-substituted heteropolyoxotungstates can act as insulin mimetic agents [26]. In the present study, we report the antibacterial activity of HPA1, HPA2 and HPA3 in combination with vancomycin and penicillin G against MRSA.…”

Section: Introductionmentioning

confidence: 69%

Vanadium(V)-substituted Keggin-type heteropolyoxotungstophosphates as electron transfer and antimicrobial agents: oxidation of glutathione and sensitization of MRSA towards β-lactam antibiotics

Sami¹,

Anand²,

Premanathan³

et al. 2010

Transition Met Chem

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Glutathione (GSH) undergoes facile electron transfer with vanadium(V)-substituted Keggin-type heteropolyoxometalates, ½PV V W 11 O 40 4À (HPA1) and ½PV V -V V W 10 O 40 5À (HPA2). The kinetics of these reactions have been investigated in phthalate buffers spectrophotometrically at 25°C in aqueous medium. One mole of HPA1 consumes one mole of GSH and the product is the oneelectron reduced heteropoly blue, ½PV IV W 11 O 40 5À . But in the GSH-HPA2 reaction, one mole of HPA2 consumes two moles of GSH and gives the two-electron reduced heteropoly blue ½PV IV V IV W 10 O 40 7À . Both reactions show overall third-order kinetics. At constant pH, the order with respect to both [HPA] species is one and order with respect to [GSH] is two. At constant [GSH], the rate shows inverse dependence on [H ? ], suggesting participation of the deprotonated thiol group of GSH in the reaction. A suitable mechanism has been proposed and a rate law for the title reaction is derived. The antimicrobial activities of HPA1, HPA2 and ½PV V V V V V W 9 O 40 6À (HPA3) against MRSA were tested in vitro in combination with vancomycin and penicillin G. The HPAs sensitize MRSA towards penicillin G.

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Section: Introductionmentioning

confidence: 69%

Vanadium(V)-substituted Keggin-type heteropolyoxotungstophosphates as electron transfer and antimicrobial agents: oxidation of glutathione and sensitization of MRSA towards β-lactam antibiotics

Sami¹,

Anand²,

Premanathan³

et al. 2010

Transition Met Chem

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“…antiviral). [13,14] Recently we have structurally characterized some dimeric and tetrameric titanium-substituted polyoxotungstates based on the Wells-Dawson fragment. [15] Soon afterwards Nomiya et al reported similar tetrameric species.…”

mentioning

confidence: 99%

Structural Control on the Nanomolecular Scale: Self‐Assembly of the Polyoxotungstate Wheel [{β‐Ti₂SiW₁₀O₃₉}₄]²⁴⁻

et al. 2004

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“…The benzimidazole analog of Johnson & Johnson showed potent anti-RSV activity in cell cultures and animal models [108,109]. In cell culture studies, Abbott reported inhibition of RSV by diacetyl tartaric acid mono and diglycerides (DATEM) and Nissin reported inhibition with a sulfated sialyl lipid (NMSO3) [109][110][111]. Enzimidazole from Trimeris inhibited membrane fusion-associated events including syncytium formation with 50% inhibition at 0.01 mg/ml [112].…”

Section: Antiviral Compoundsmentioning

confidence: 99%

New drugs and treatment for respiratory syncytial virus

Maggon¹,

Barik

2004

Reviews in Medical Virology

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The respiratory syncytial virus (RSV) is a global health problem affecting infants and the elderly and claiming more lives than AIDS in many parts of the world. Only two antibody drugs are approved for its prevention, and ribavarin, a relatively nonspecific antiviral, is used for treatment. In the mid-1990s, a number of pharmaceutical and biotech companies initiated research programs against RSV. Together, the academic and the industrial R&D covered the whole spectrum of antibodies, vaccines, synthetic small molecule antiviral and antisense technology, and at one point, accounted for at least 25 active R&D programs. However, coincident to the marketing of the monoclonal antibody palivizumab (Synagis) in 1998, a sharp decline in such projects ensued. Many companies recently cancelled RSV projects during a prioritisation of their R&D portfolios although the continuing medical need, large market size and sales projections clearly indicate that a safe and effective RSV drug or vaccine is likely to attain blockbuster status. Today RSV receives an insignificant fraction of the R&D budget compared with AIDS, for example. This article reviews the present status of the anti-RSV regimen, covers drugs in the market and in development, and attempts to link basic research to industrial drug development, animal models of RSV, clinical trials, current clinical management, and present and future market projections. It is hoped that the unmet medical need of the victims of RSV will encourage continued involvement of the pharmaceutical and biotechnology industry in developing safe and effective prevention and treatments for RSV.

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Broad spectrum anti-RNA virus activities of titanium and vanadium substituted polyoxotungstates

Cited by 121 publications

References 20 publications

Vanadium(V)-substituted Keggin-type heteropolyoxotungstophosphates as electron transfer and antimicrobial agents: oxidation of glutathione and sensitization of MRSA towards β-lactam antibiotics

Vanadium(V)-substituted Keggin-type heteropolyoxotungstophosphates as electron transfer and antimicrobial agents: oxidation of glutathione and sensitization of MRSA towards β-lactam antibiotics

Structural Control on the Nanomolecular Scale: Self‐Assembly of the Polyoxotungstate Wheel [{β‐Ti₂SiW₁₀O₃₉}₄]²⁴⁻

New drugs and treatment for respiratory syncytial virus

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Broad spectrum anti-RNA virus activities of titanium and vanadium substituted polyoxotungstates

Cited by 121 publications

References 20 publications

Vanadium(V)-substituted Keggin-type heteropolyoxotungstophosphates as electron transfer and antimicrobial agents: oxidation of glutathione and sensitization of MRSA towards β-lactam antibiotics

Vanadium(V)-substituted Keggin-type heteropolyoxotungstophosphates as electron transfer and antimicrobial agents: oxidation of glutathione and sensitization of MRSA towards β-lactam antibiotics

Structural Control on the Nanomolecular Scale: Self‐Assembly of the Polyoxotungstate Wheel [{β‐Ti2SiW10O39}4]24−

New drugs and treatment for respiratory syncytial virus

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Structural Control on the Nanomolecular Scale: Self‐Assembly of the Polyoxotungstate Wheel [{β‐Ti₂SiW₁₀O₃₉}₄]²⁴⁻