Broad range metabolomics coupled with network analysis for explaining possible mechanisms of Er-Zhi-Wan in treating liver-kidney Yin deficiency syndrome of Traditional Chinese medicine

Zhai, Yuanyuan; Xu, Jian; Li, Feng; Liu, Qinan; Yao, Weifeng; Li, Hui; Cao, Yudan; Cheng, Fang; Bao, Beihua; Zhang, Li

doi:10.1016/j.jep.2019.01.019

Cited by 19 publications

(8 citation statements)

References 57 publications

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“…Maintaining dynamic homeostasis of the human body is its basic principle [14] . The core pathogenesis of lung cancer in TCM results from a homeostatic imbalance, including disharmony of the spleen and stomach, [15] deficiency of qi and blood, [14] and Yin deficiency of the liver and kidney [16,17] . We followed the corresponding prescriptions to form the TCM treatment decoction in this study, including strengthening the spleen and stomach, nourishing qi and blood, and nourishing the liver and kidney, to restore internal balance.…”

Section: Introductionmentioning

confidence: 99%

Comprehensive TCM treatments combined with chemotherapy for advanced non-small cell lung cancer

et al. 2021

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Objective: We conducted this study to evaluate the efficacy and safety of traditional Chinese medicine (TCM) in advanced non-small cell lung cancer (NSCLC) patients who underwent chemotherapy. Design: This was a prospective, open-label, randomized controlled trial. NSCLC patients at stage IIIA, IIIB, or IV were randomly assigned to either TCM plus chemotherapy or chemotherapy alone. The comprehensive TCM treatment consisted of Kang Ai injection, herbal decoction, and Zhenqifuzheng capsules. The primary endpoint was quality of life (QOL) measured by the Functional Assessment of Cancer Therapy-Lung version 4.0. The secondary endpoints were chemotherapy completion rate, tumor response, and adverse events. All assessments were done at baseline, the third week, and the sixth week. Results: Thirty-nine participants were randomly assigned to the treatment group and 36 to the control group. The QOL scores were significantly improved in the treatment group compared with those of the control group in social well-being (cycle 1, P = .048; cycle 2, P = .015), emotional well-being (cycle 1, P = .047; cycle 2, P = 4.29E-05), and functional well-being (cycle 1, P = .030; cycle 2, P = .003), while the QOL scores in the above 3 domains declined in the control group ( P < .05). Both groups had a decline in the physical well-being score (cycle 1, P = .042; cycle 2, P = .017) and lung cancer symptom score (cycle 1, P = .001; cycle 2, P = .001) after 2 courses of intervention. The deterioration in physical well-being and lung cancer symptoms was noticeably smaller in the treatment group ( P < .05). There were significant differences between the 2 groups in social well-being, emotional well-being, functional well-being, lung cancer symptom domain, and the total score ( P < .05). Patients in the treatment group had a significantly lower incidence of platelet reduction than the control group ( P = .028) after 2 cycles of treatment. No significant difference in nonhematological adverse events (AEs) was observed. Conclusion: This study illustrated that comprehensive TCM treatment could promote the QOL of NSCLC patients, alleviate symptoms, and reduce the AEs caused by chemotherapy, verifying the synergistic and attenuating effects of TCM in NSCLC patients undergoing chemotherapy. Trial registration: Chinese Clinical Trial Registry ( www.chictr.org.cn ): ChiCTR-TRC-13003637

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Section: Introductionmentioning

confidence: 99%

Comprehensive TCM treatments combined with chemotherapy for advanced non-small cell lung cancer

et al. 2021

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“…The mechanism was found to be related to the MAVS-mediated signaling pathway [55]. Additionally, according to broad-range metabolomics coupled with network analysis, it was found that formulation-based TCM syndromes might prevent the pathological process of liver-kidney yin deficiency syndrome (LKYDS) through regulating the aging genes, such as CAV1 and ACO1 [56]. “Bushen” based on TCM theory could improve the immune system and delay the progression of the disease.…”

Section: Discussionmentioning

confidence: 99%

HLA-DQB1/DRB1 Alleles Associate with Traditional Chinese Medicine Syndrome of Chronic Hepatitis B: A Potential Predictor of Progression

Liu

Wan

Dang³

et al. 2019

BioMed Research International

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Background and Aims Traditional Chinese medicine (TCM) has been widely applied in chronic hepatitis B (CHB) supplementary treatment in China. Kidney yang deficiency syndrome (KYDS), one of the most common TCM syndromes of CHB, is more likely to progress to liver cirrhosis or hepatocellular carcinoma than other syndromes. Polymorphisms in the human leucocyte antigen- (HLA-) DQB1 and -DRB1 genes were reported to be associated with hepatitis B virus infection outcomes. Here, we investigated whether HLA-DQB1 and HLA-DRB1 are associated with the classification of CHB TCM syndromes. Methods We genotyped HLA-DQB1 and HLA-DRB1 alleles in a total of 105 subjects, including 74 CHB patients (28 KYDS and 46 non-KYDS) and 31 healthy individuals from Sichuan Province of Southwest China, by polymerase chain reaction sequence-based typing (PCR-SBT). Moreover, a meta-analysis was carried out for further verification. Results The proportion of patients with high HBV DNA load (≥2000 IU/ml) in the KYDS group is higher than that in the non-KYDS group (60.70% [17/28] vs. 28.30% [13/46]); P=0.01). The frequencies of HLA-DQB1∗02:01 (P=0.04) and HLA-DRB1∗03:01 (P=0.04) in the KYDS group were significantly increased compared to the non-KYDS group. The gene test and meta-analysis showed that HLA-DRB1∗08:03 confers susceptibility to CHB (odds ratio = 1.57). Conclusion We found an association between HLA-DRB1/DQB1 polymorphisms and KYDS of CHB. Moreover, KYDS patients of CHB are characteristic with high HBV DNA loads. These findings help to reveal the biological mechanism of KYDS in high risk of CHB progression and suggest a potential prognostic value for disease outcome evaluation.

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“…With the aid of Metscape, a plugin in Cytoscape software, the lipid-enzyme-gene network was constructed (Figure S2). After the calculation of the node centralities, the core lipid-enzyme-gene subnetwork was extracted [28,29]. Finally, twelve enzymes including lysophospholipase, phospholipase, ceramidase, SM phosphodiesterase, and so forth were considered as core proteins related to the hypolipidemic efficacy of HZ (Figure 5B).…”

Section: Network Analysismentioning

confidence: 99%

Ultra‐high performance liquid chromatography‐quadrupole/time‐of‐flight mass spectrometry‐based lipidomics reveals key lipid molecules as potential therapeutic targets of Polygonum cuspidatum against hyperlipidemia in a hamster model

Yang

et al. 2023

J of Separation Science

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Polygonum cuspidatum is a homology of traditional medicine and functional food widely distributed around the world. Our previous study on the hyperlipidemic animal model demonstrated that Polygonum cuspidatum was effective in ameliorating hyperlipidemia, which is characterized by lipid disorders. Herein, the regulatory effect of Polygonum cuspidatum on lipid metabolism needs to be known if its hypolipidemic mechanism is desired to clarify. In this study, an ultra-high performance liquid chromatography-quadrupole/time-of-flight mass spectrometry-based lipidomic strategy was first applied to investigate the lipidomic patterns of high-fat diet-induced hyperlipidemic hamsters when treated with Polygonum cuspidatum. The results showed that Polygonum cuspidatum improved the lipidomic profile of hyperlipidemia. A total of 65 differential lipids related to the hypolipidemic effect of Polygonum cuspidatum were screened out and identified, and these differential lipids covered various categories, such as phosphatidylcholines, phosphatidylethanolamines, triacylglycerols, sphingomyelins and so on. Orally administrated Polygonum cuspidatum restored these differential lipids back to normal or nearly normal levels. This study adopted lipidomics to reveal the key lipid molecules as potential therapeutic targets of

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Broad range metabolomics coupled with network analysis for explaining possible mechanisms of Er-Zhi-Wan in treating liver-kidney Yin deficiency syndrome of Traditional Chinese medicine

Cited by 19 publications

References 57 publications

Comprehensive TCM treatments combined with chemotherapy for advanced non-small cell lung cancer

Comprehensive TCM treatments combined with chemotherapy for advanced non-small cell lung cancer

HLA-DQB1/DRB1 Alleles Associate with Traditional Chinese Medicine Syndrome of Chronic Hepatitis B: A Potential Predictor of Progression

Ultra‐high performance liquid chromatography‐quadrupole/time‐of‐flight mass spectrometry‐based lipidomics reveals key lipid molecules as potential therapeutic targets of Polygonum cuspidatum against hyperlipidemia in a hamster model

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