Broad cross-national public support for accelerated COVID-19 vaccine trial designs

Broockman, David E.; Kalla, Joshua; Guerrero, A.C. Marín; Budolfson, Mark; Eyal, Nir; Jewell, Nicholas P.; Magalhães, Monica; Sekhon, Jasjeet S.

doi:10.1016/j.vaccine.2020.11.072

Cited by 11 publications

(8 citation statements)

References 27 publications

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“…Not only was public funding made available almost immediately, but bureaucratic hurdles were handled much more quickly than in other clinical trials, and conditional licensing applications were processed in a prioritised fashion by regulatory authorities. Moreover, clinical trial recruitment was exceptionally successful ( Broockman et al, 2021 ). While this acceleration eventually led to the early availability of several COVID-19 vaccines, many of our participants - including those with positive stances on vaccination more generally - expressed concerns related to the speed of COVID-19 vaccine development as compared to previous vaccines.…”

Section: Resultsmentioning

confidence: 99%

Anticipating hopes, fears and expectations towards COVID-19 vaccines: A qualitative interview study in seven European countries

Zimmermann

Corsico

Fiske

et al. 2022

SSM - Qualitative Research in Health

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Vaccine uptake is essential to managing the ongoing COVID-19 pandemic, and vaccine hesitancy is a persistent concern. At the same time, both decision-makers and the general population have high hopes for COVID-19 vaccination. Drawing from qualitative interview data collected in October 2020 as part of the pan-European SolPan study, this study explores early and anticipatory expectations, hopes and fears regarding COVID-19 vaccination across seven European countries. We find that stances towards COVID-19 vaccines were shaped by personal lived experiences, but participants also aligned personal and communal interests in their considerations. Trust, particularly in expert institutions, was an important prerequisite for vaccine acceptance, but participants also expressed doubts about the rapid vaccine development process. Our findings emphasise the need to move beyond the study of factors driving vaccine hesitancy, and instead to focus on how people personally perceive vaccination in their particular social and political context.

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Section: Resultsmentioning

confidence: 99%

Anticipating hopes, fears and expectations towards COVID-19 vaccines: A qualitative interview study in seven European countries

Zimmermann

Corsico

Fiske

et al. 2022

SSM - Qualitative Research in Health

View full text Add to dashboard Cite

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“…More recent work has looked at cross-national comparisons of vaccine attitudes through the lens of COVID. 22 , 23 …”

Section: Prior Workmentioning

confidence: 99%

Estimating the size of “anti-vax” and vaccine hesitant populations in the US, UK, and Canada: comparative latent class modeling of vaccine attitudes

Gravelle

Phillips

Reifler

et al. 2022

Human Vaccines & Immunotherapeutics

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Vaccine hesitancy is a significant impediment to global efforts to vaccinate against the SARS-CoV-2 virus at levels that generate herd immunity. In this article, we show the utility of an inductive approach – latent class analysis (LCA) – that allows us to characterize the size and nature of different vaccine attitude groups; and to compare how these groups differ across countries as well as across demographic subgroups within countries. We perform this analysis using original survey data collected in the US, UK, and Canada. We also show that these classes are strongly associated with SARS-CoV-2 vaccination intent and perceptions of the efficacy and safety of the COVID-19 vaccines, suggesting that attitudes about vaccines to fight the novel coronavirus pandemic are well explained by latent vaccine attitudes that precede the pandemic. More specifically, we find four substantive classes of vaccine attitudes: strong supporters, supporters with concerns, vaccine hesitant, and “anti-vax” as well as a fifth measurement error class. The strong “anti-vax” sentiment class is small in all three countries, while the strong supporter class is the largest across all three countries. We observe different distributions of class assignments in different demographic groups – most notably education and political leaning (partisanship and ideology).

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“…A ‘cross-national survey (n=5920) in Australia, Canada, Hong Kong, New Zealand, South Africa, Singapore, the UK and the USA’ 48 found that ‘broad majorities prefer for scientists to conduct challenge trials (75%) … Even as respondents acknowledged the risks, they perceived … accelerated trials as similarly ethical to standard trial designs’. 48 Elsewhere, support for HCTs weathered longer deliberations. 49 Admittedly both of these studies collected data more than a year ago.…”

Section: Impact On Vaccination Rates?mentioning

confidence: 99%

Research ethics and public trust in vaccines: the case of COVID-19 challenge trials

Eyal

2022

J Med Ethics

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Despite their clearly demonstrated safety and effectiveness, approved vaccines against COVID-19 are commonly mistrusted. Nations should find and implement effective ways to boost vaccine confidence. But the implications for ethical vaccine development are less straightforward than some have assumed. Opponents of COVID-19 vaccine challenge trials, in particular, made speculative or empirically implausible warnings on this matter, some of which, if applied consistently, would have ruled out most COVID-19 vaccine trials and many non-pharmaceutical responses.

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Broad cross-national public support for accelerated COVID-19 vaccine trial designs

Cited by 11 publications

References 27 publications

Anticipating hopes, fears and expectations towards COVID-19 vaccines: A qualitative interview study in seven European countries

Anticipating hopes, fears and expectations towards COVID-19 vaccines: A qualitative interview study in seven European countries

Estimating the size of “anti-vax” and vaccine hesitant populations in the US, UK, and Canada: comparative latent class modeling of vaccine attitudes

Research ethics and public trust in vaccines: the case of COVID-19 challenge trials

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