Broad-beam three-dimensional irradiation system for heavy-ion radiotherapy at HIMAC

Futami, Yasuyuki; Kanai, Tatsuaki; Fujita, Makoto; Tomura, H.; Higashi, A.; Matsufuji, Naruhiro; Miyahara, Nobuyuki; Endo, Masahiro; Kawachi, Kiyomitsu

doi:10.1016/s0168-9002(99)00194-1

Cited by 35 publications

(20 citation statements)

References 8 publications

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“…Ridge filter is used to obtain a full spread-out Bragg peak (SOBP) for a mono-energetic ion beam to stack throughout the depth of the target volume, as used in the 2D irradiation at NIRS [9]. However, the sharp Bragg peak is slightly spread out by ripple filter to form a mini SOBP, as used in the 3D irradiations at NIRS and GSI [5,15,18] Fig. 1 The vertical beam line in the therapy terminal at HIRFL for the treatment of superficially placed tumors with carbon ions a SOBP beam at depth z is the sum of the doses of the involved individual Bragg curves at z, that is…”

Section: Range Modulatormentioning

confidence: 99%

“…Up to now 2D and 3D conformal irradiations dedicated to particle therapy have been explored on the basis of passive beam delivery system [2,5,9,11], and even have been applied to clinical trials [9,10]. Because the passive beam delivery system mentioned above has been developed in the therapy terminal at HIRFL, 2D and 3D conformal irradiations to shallow-seated tumors can be easily performed.…”

Section: Conformal Irradiationsmentioning

confidence: 99%

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Heavy-ion conformal irradiation in the shallow-seated tumor therapy terminal at HIRFL

Dai

Yan

et al. 2007

Med Bio Eng Comput

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Basic research related to heavy-ion cancer therapy has been done at the Institute of Modern Physics (IMP), Chinese Academy of Sciences since 1995. Now a plan of clinical trial with heavy ions has been launched at IMP. First, superficially placed tumor treatment with heavy ions is expected in the therapy terminal at the Heavy Ion Research Facility in Lanzhou (HIRFL), where carbon ion beams with energy up to 100 MeV/u can be supplied. The shallow-seated tumor therapy terminal at HIRFL is equipped with a passive beam delivery system including two orthogonal dipole magnets, which continuously scan pencil beams laterally and generate a broad and uniform irradiation field, a motor-driven energy degrader and a multi-leaf collimator. Two different types of range modulator, ripple filter and ridge filter with which Guassian-shaped physical dose and uniform biological effective dose Bragg peaks can be shaped for therapeutic ion beams respectively, have been designed and manufactured. Therefore, two-dimensional and three-dimensional conformal irradiations to tumors can be performed with the passive beam delivery system at the earlier therapy terminal. Both the conformal irradiation methods have been verified experimentally and carbon-ion conformal irradiations to patients with superficially placed tumors have been carried out at HIRFL since November 2006.

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Section: Range Modulatormentioning

confidence: 99%

Section: Conformal Irradiationsmentioning

confidence: 99%

Heavy-ion conformal irradiation in the shallow-seated tumor therapy terminal at HIRFL

Dai

Yan

et al. 2007

Med Bio Eng Comput

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“…Beam delivery to date has been the 2-D system with wobbler magnets. 3-D treatments with range-stacking and a multi-leaf collimator will be started in the coming year 26 . A fourth treatment room is being commissioned, for exclusive use with radioactive 11 C, for both diagnostic, as well as treatment of small fields.…”

Section: Himacmentioning

confidence: 99%

Medical applications of nuclear physics and heavy-ion beams

Alonso¹

2001

Nuclear Physics A

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“…In radiation therapy, proton [1][2][3][4][5] and heavy-ion beams [6][7][8][9][10] have a great advantage over X-rays because of the high radiation biological effectiveness (RBE) of providing biological damage on malignant tumors and also of suppressing the fast recovery of the DNA. Furthermore, the well-controlled delivery, of the radiation to the planned treatment volume (PTV) and the well-defined depth of interaction, minimize an unnecessary delivery of the dose to normal tissue or sensitive organs surrounding the cancer tumor.…”

Section: Introductionmentioning

confidence: 99%

Test of a Multilayer Dose-Verification Gaseous Detector with Raster-Scan-Mode Proton Beams

Lee¹,

Ahn²,

Han³

et al. 2015

IEIE Transactions on Smart Processing and Computing

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A multilayer gaseous detector has been developed for the fast dose-verification measurements of raster-scan-mode therapeutic beams in particle therapy. The detector, which was constructed with eight thin parallel plate ionization chambers (PPICs) and polymethyl methacrylate (PMMA) absorber plates, is closely tissue-equivalent in a beam's eye view (BEV). The gas-electron signals, collected on the strips and pad arrays of each PPIC, were amplified and processed with a continuous charge-integration mode. The detector was test with 190-MeV raster-scan-mode beams that were provided by the Proton Therapy Facility at Samsung Medical Center, Seoul, South Korea. The detector responses, of the PPICs for a 190-MeV raster-scan-mode proton beam, agreed well with the doses predicted by the GEANT4 simulations. Furthermore, in this study it was confirmed that the detector simultaneously tracked the doses induced at the PPICs by the fast-oscillating beam, with a scanning speed of 2 m s -1. Thus, it is anticipates that the present detector, composed of thin PPICs and operating in the charge-integration mode, will allow medical scientists to perform reliable fast dose verification measurements for the typical dynamic mode therapeutic beams.

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Broad-beam three-dimensional irradiation system for heavy-ion radiotherapy at HIMAC

Cited by 35 publications

References 8 publications

Heavy-ion conformal irradiation in the shallow-seated tumor therapy terminal at HIRFL

Heavy-ion conformal irradiation in the shallow-seated tumor therapy terminal at HIRFL

Medical applications of nuclear physics and heavy-ion beams

Test of a Multilayer Dose-Verification Gaseous Detector with Raster-Scan-Mode Proton Beams

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