Brittle nail syndrome: A pathogenesis-based approach with a proposed grading system

Kerkhof, P.C.M. van de; Pasch, Marcel C.; Scher, Richard K.; Kerscher, Martina; Gieler, Uwe; Haneke, E.; Fleckman, Philip

doi:10.1016/j.jaad.2004.09.002

Cited by 80 publications

(51 citation statements)

References 40 publications

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“…The mean water content of the nail plates in this analysis (12.05%) was within the range of the water content of normal nails reported in the literature (7%-18%). [2][3][4][6][7][8][9][10] In this investigation, although the difference was not statistically significant, brittle nails had higher nail plate water content than normal nails. Water percentage results varied more within a single participant than between participants.…”

Section: Discussionmentioning

confidence: 97%

“…This is an important finding given the multitude of authors who also mention moisturizing as a potential treatment regimen for brittle nails. 2,7,8,12,13 In addition, this finding may suggest that people who have brittle nails also tend to have dry skin, which may also imply that people with brittle nails attempt to self-treat their hands and nails with moisturizers more frequently. Professional manicures were associated with brittle nails.…”

Section: Discussionmentioning

confidence: 99%

“…5,7 The diagnostic criteria in the literature for brittle nails are not well defined. We used the definition elaborated by Kechijian, 8 who describes brittle nails as having two pathologic alterations: (1) excessive onychorrhexis (longitudinal ridging) that results in distal splitting; and/or (2) onychoschizia (horizontal layering).…”

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confidence: 99%

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Water content and other aspects of brittle versus normal fingernails

Stern¹,

Diamantis²,

Smith³

et al. 2007

Journal of the American Academy of Dermatology

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

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Water content and other aspects of brittle versus normal fingernails

Stern¹,

Diamantis²,

Smith³

et al. 2007

Journal of the American Academy of Dermatology

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“…30,31 Its tip is pressed a few seconds directly on the nail surface of the index (IN), the medium (ME) and the ring (RI) finger of the right or the left hand, (in right-or left-handed individuals, respectively). 32 The hardness value is assessed as the mean value of three repetitive measures in the same area of each finger.…”

Section: Nails Parameters Clinical Evaluation: a Durometer Device [Dumentioning

confidence: 99%

A dietary supplement improves age-related dermatological changes. Observational, anecdotal, spontaneous study.

et al. 2017

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Skin ageing involves also its annexes, such as hair and nails. Hair follicles are produced during embryogenesis. 1 In the postnatal life, hair follicle grows through three distinct phases: (i) anagen (growth) phase; (ii) catagen (regressing) phase; and (iii) telogen (resting) phase.2 This puzzling selfrenewal property is maintained by the stem cell niche located in the bulge portion of the hair follicle. 3 The hair follicle has a highly complex structure with eight distinct cell layers. The nail is hard keratin adnexa, produced by the same germinative epithelium and process through which epidermal skin cells produce the stratum corneum. Nail keratinocytes contribute to cornification through the production of hard keratins and the hardness of the nail plate is due to a high concentration of sulfur matrix protein. 4The rate of people with significant dermis and epidermis disorders increases linearly with age: at 70 years about 70% of the population claims at least one related-skin problem. 5The loss of hydration, appearance of fine wrinkles, roughness, dryness, thickening, laxity, telangiectasia, and loss of tensile strength are common features of the A B S T R A C T ORIGINAL ARTICLE ASIAN JOURNAL OF MEDICAL SCIENCESBackground: The rate of people with significant dermis and epidermis disorders increases linearly with age. The majority of skin changes are a consequence of cumulative exposure to environmental factors, such as chronic ultraviolet exposure. Aims and Objectives: Age-related dermatological changes include skin laxity, nails fragility, hair loss and hair breakage. This spontaneous, anecdotal observational study investigates if a dietary supplementation based on collagen, chondroitin sulfate, low-molecular weight hyaluronic acid, Pycnogenol® and coenzyme Q10 can improve age-related dermatological changes. Materials and Methods: Thirty four patients received the dietary supplement for 2 times/daily for 12 weeks. Facial skin hydration, Trans Epidermal Water Loss (TEWL) and elasticity were assessed at baseline and after 12 weeks in five selected areas. Nails hardness of the index, middle and ring fingers were also assessed at baseline and at followup by a durometer and by a nail score. The Hair Mass Index (HMI) and the Hair Breakage Index (HBI) were assessed by a mechanical device together with hair score at baseline and after 12 weeks. Results: After 12 weeks skin hydration, TEWL and elasticity significantly improved in all the tested areas (p < 0.01 and p < 0.001). Nails hardness of index, middle and ring finger significantly increased (p < 0.001) after 12 weeks. HMI and HBI were both significantly reduced (p < 0.0001) after 12 weeks. In addition, both nails and hair score improved. Conclusions: Dietary supplementation significantly improved age-related dermatological changes.

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Originalien Hintergrund und FragestellungBrüchige, splitternde wie auch weiche Nä-gel sind ein sehr häufiges Problem, unter dem ungefähr 20% der Bevölkerung leiden, wobei Frauen etwa doppelt so häufig betroffen sind wie Männer [12,17,21,22]. Klinisch können -isoliert oder kombiniert -vermehrte Brüchigkeit der Nagelplatte mit schichtweisem Abblättern vom distalen Rand (Onychoschisis) und/oder längsfaserigem Aufsplittern (Onychorrhexis) sowie bröckliges oder querlaufendes Abbrechen beobachtet werden, wobei der Begriff "brüchige Nägel" klinisch wie auch pathogenetisch nicht eindeutig definiert ist [12,22].

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