British Ocular Syphilis Study (BOSS): 2-Year National Surveillance Study of Intraocular Inflammation Secondary to Ocular Syphilis

Mathew, Rajeev; Goh, B T; Westcott, Mark

doi:10.1167/iovs.14-14559

Cited by 111 publications

(140 citation statements)

References 20 publications

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“…This re-emphasizes the risk of coinfection with other sexually transmitted diseases in this patient group, and the desirability to test for HIV in case of ocular syphilis. Previously, HIV positivity has been associated with a worse visual outcome in syphilitic uveitis, a finding we and other recent studies [9][10][11]24,25 could not confirm. Also, previous studies described that HIV-positive patients tended to have a higher proportion of posterior and panuveitis and neurosyphilis than HIV-negative patients.…”

Section: Hivcontrasting

confidence: 94%

Clinical Manifestations and Outcome of Syphilitic Uveitis

Bollemeijer¹,

Wieringa

Missotten

et al. 2016

Invest. Ophthalmol. Vis. Sci.

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RESULTS. Mean age was 47 years (range, 27-73 years), 82.4% were male. HIV positivity was found in 28 (35.9%) patients; 13 were newly diagnosed. Most patients had pan (45.9%) or posterior (31.8%) uveitis. On average, logMAR visual acuity (VA) improved significantly from 0.55 at the start of syphilis treatment to 0.34 at 1 month and to 0.27 at 6 months follow-up. Most patients (86.7%) reached disease remission. No differences in efficacy between the various treatment regimens were found. A high logMAR VA at the start of syphilis treatment and a treatment delay of more than 12 weeks were prognostic for a high logMAR VA at 6 months follow-up. Chronicity was not related to any form of treatment, HIV status, or Venereal Disease Research Laboratory test outcome. CONCLUSIONS.In this large cohort of 85 patients with syphilitic uveitis, visual outcomes were favorable in the majority of cases. Visual outcome was dependent on VA at the start of syphilis treatment and treatment delay.

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Section: Hivcontrasting

confidence: 94%

Clinical Manifestations and Outcome of Syphilitic Uveitis

Bollemeijer¹,

Wieringa

Missotten

et al. 2016

Invest. Ophthalmol. Vis. Sci.

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“…Ocular manifestations were present in 0.60% of all reported syphilis cases, ranging by jurisdiction from 0.17% to 3.9%. In most jurisdictions, the percentage was similar to data from a study in England that estimated ocular syphilis affected approximately 0.6% of early syphilis cases from 2009 to 2010 (5). Five of the seven jurisdictions that reviewed cases in both years described an increase in suspected ocular syphilis cases in 2014 and 2015.…”

Section: Discussionsupporting

confidence: 78%

Ocular Syphilis — Eight Jurisdictions, United States, 2014–2015

Oliver¹,

Aubin²,

Atwell³

et al. 2016

MMWR Morb. Mortal. Wkly. Rep.

116

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“…The authors of the British Ocular Syphilis Study (BOSS) estimated that ocular syphilis occurred in 0.6% of cases of early syphilis 7. This figure is similar to that reported in the USA 8.…”

Section: Discussionsupporting

confidence: 67%

Syphilitic jaundice: a rare manifestation of the secondary stage presenting a missed opportunity to prevent ocular syphilis

Curran¹,

Higgins

2018

BMJ Case Reports

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The classical presentation of secondary syphilis comprises skin rashes, mucosal ulceration and lymphadenopathy. However, this disseminated stage can also present with symptoms and signs of ocular, neurological, pulmonary, renal, musculoskeletal and digestive tract disease. We report the case of a gay man who presented with icteric hepatitis. Although he underwent an exhaustive series of investigations (some of which were invasive), syphilis was not initially considered in the differential diagnosis. His jaundice resolved spontaneously, but he subsequently developed an acute optic neuritis. Early syphilis is relatively common in men who have sex with men (MSM). Prompt diagnosis and treatment in this case would have prevented ocular involvement. Syphilis testing should be considered in all MSM presenting with unexplained symptoms and signs.

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British Ocular Syphilis Study (BOSS): 2-Year National Surveillance Study of Intraocular Inflammation Secondary to Ocular Syphilis

Cited by 111 publications

References 20 publications

Clinical Manifestations and Outcome of Syphilitic Uveitis

Clinical Manifestations and Outcome of Syphilitic Uveitis

Ocular Syphilis — Eight Jurisdictions, United States, 2014–2015

Syphilitic jaundice: a rare manifestation of the secondary stage presenting a missed opportunity to prevent ocular syphilis

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