British Neuropathological Society and International Society of Forensic Radiology and Imaging expert consensus statement for <i>post mortem</i> neurological imaging

Shelmerdine, Susan C.; Hutchinson, J. Ciaran; Al‐Sarraj, Safa; Cary, N.; Dawson, Timothy; Plessis, Daniel du; Ince, Paul G.; McLaughlin, Siobhan; Palm, Liina; Smith, Chery; Stoodley, Neil; Rijn, Rick R. van; Arthurs, Owen J.; Jacques, Thomas S.

doi:10.1111/nan.12482

Cited by 7 publications

(3 citation statements)

References 19 publications

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“…The British Neuropathological Society (BNS) and International Society of Forensic Imaging (ISFRI) have published a joint consensus statement regarding when post-mortem neurological imaging may be helpful. 49 In this, they suggest post-mortem imaging of the brain where there is a high likelihood that the brain may be autolysed and damaged by autopsy extraction, and to help confirm diagnoses resulting in a termination of pregnancy. The modality of choice should be determined by the radiologist and pathologist involved in the case.…”

Section: Introductionmentioning

confidence: 99%

Post-mortem perinatal imaging: what is the evidence?

Shelmerdine

Arthurs

2022

BJR

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Post-mortem imaging for the investigation of perinatal deaths is an acceptable tool amongst parents and religious groups, enabling a less invasive autopsy examination. Nevertheless, availability is scarce nationwide, and there is some debate amongst radiologists regarding the best practice and optimal protocols for performing such studies. Much of the published literature to date focusses on single centre experiences or interesting case reports. Diagnostic accuracy studies are available for a variety of individual imaging modalities (e.g., post-mortem CT, MRI, ultrasound and micro-CT), however assimilating this information is important when attempting to start a local service. In this article, we present a comprehensive review summarising the latest research, recently published international guidelines, and describe which imaging modalities are best suited for specific indications. When the antenatal clinical findings are not supported by the post-mortem imaging, we also suggest how and when an invasive autopsy may be considered. In general, a collaborative working relationship within a multidisciplinary team (consisting of radiologists, radiographers, the local pathology department, mortuary staff, fetal medicine specialists, obstetricians and bereavement midwives) is vital for a successful service.

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Section: Introductionmentioning

confidence: 99%

Post-mortem perinatal imaging: what is the evidence?

Shelmerdine

Arthurs

2022

BJR

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“…Although both these methods of MIA are more appealing than a fully invasive autopsy, one challenging area is the assessment of the brain and spinal cord. Post‐mortem MRI (PMMR) is the preferred choice for foetal intracranial abnormalities, although any uncertainties at imaging will likely require whole brain extraction and fixation, rather than brain biopsies. This is particularly in the perinatal cohort when assessing developmental structural anomalies, as complex intracranial abnormalities identified on antenatal ultrasound can be missed on PMMR …”

Section: Introductionmentioning

confidence: 99%

Latest developments in post‐mortem foetal imaging

et al. 2019

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A sustained decline in parental consent rates for perinatal autopsies has driven the development of less‐invasive methods for death investigation. A wide variety of imaging modalities have been developed for this purpose and include post‐mortem whole body magnetic resonance imaging (MRI), ultrasound, computed tomography (CT) and micro‐focus CT techniques. These are also vital for “minimally invasive” methods, which include potential for tissue sampling, such as image guidance for targeted biopsies and laparoscopic‐assisted techniques. In this article, we address the range of imaging techniques currently in clinical practice and those under development. Significant advances in high‐field MRI and micro‐focus CT imaging show particular promise for smaller and earlier gestation foetuses. We also review how MRI biomarkers such as diffusion‐weighted imaging and organ volumetric analysis may aid diagnosis and image interpretation in the absence of autopsy data. Three‐dimensional printing and augmented reality may help make imaging findings more accessible to parents, colleagues and trainees.

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“…Compared to conventional paediatric autopsy practices, postmortem CT is noninvasive examination and provides a three-dimensional (3-D) digital record of anatomical information that can be post-processed in a variety of ways for clinical, research and teaching purposes. This is particularly useful where sanitised images are required for a jury in medicolegal proceedings, or to show family members when explaining the cause of death [ 6 ]. Although few publications relate to the diagnostic accuracy rates of paediatric postmortem CT, those published report reasonable concordance rates with autopsy of between 57.1% and 83.3% [ 4 , 5 , 7 , 8 ], particularly for musculoskeletal abnormalities such as fractures.…”

Section: Introductionmentioning

confidence: 99%

Joint European Society of Paediatric Radiology (ESPR) and International Society for Forensic Radiology and Imaging (ISFRI) guidelines: paediatric postmortem computed tomography imaging protocol

et al. 2019

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Postmortem CT for investigating childhood deaths is increasingly utilised as a noninvasive adjunct or alternative to standard autopsy; however there are no standardised published imaging protocols. This article describes a standardised imaging protocol that has been developed based on current practices of international postmortem imaging practitioners and experts. This recommendation is expected to be useful for postmortem imaging centres wishing to update their existing practices and for those starting paediatric postmortem CT as a new service.

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British Neuropathological Society and International Society of Forensic Radiology and Imaging expert consensus statement for post mortem neurological imaging

Abstract: The BNS/ISFRI statement represents current views of an expert panel of health professionals engaged in post-mortem neuroimaging. We hope this provides a working guideline for less experienced operators, stimulates discussion and highlights the most pressing clinical and research questions.

Cited by 7 publications

References 19 publications

Post-mortem perinatal imaging: what is the evidence?

Post-mortem perinatal imaging: what is the evidence?

Latest developments in post‐mortem foetal imaging

Joint European Society of Paediatric Radiology (ESPR) and International Society for Forensic Radiology and Imaging (ISFRI) guidelines: paediatric postmortem computed tomography imaging protocol

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