British HIV Association guidelines for the treatment of <scp>HIV</scp>‐1‐positive adults with antiretroviral therapy 2015

Churchill, Duncan; Waters, Laura; Ahmed, Nadia; Angus, Brian; Boffito, Marta; Bower, Mark; Dunn, David; Edwards, Simon; Emerson, Carol; Fidler, Sarah; Fisher, Martin; Horne, Rob; Khoo, Saye; Leen, Clifford; Mackie, Nicola; Marshall, Neal; Monteiro, Filipa; Nelson, Mark; Orkin, Chloe; Palfreeman, Adrian; Pett, Sarah; Phillips, Andrew; Post, Frank A.; Pozniak, Anton; Reeves, Iain; Sabin, Caroline; Trevelion, Roy; Walsh, John; Wilkins, Ed; Williams, Ian; Winston, Alan

doi:10.1111/hiv.12426

Cited by 91 publications

(76 citation statements)

References 625 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CD4+ T-cell enumeration, along with plasma HIV RNA (viral load) are the predominant biomarkers for assessment of patient compliance and disease progression (1,4,5,11). The panel is used to identify and enumerate T cells including CD4 and CD8 T-cell subsets, B cells (CD19+ cells) and NK cells (CD16/56+ cells) within patient blood samples and is typically used for monitoring individuals with HIV.…”

Section: Introductionmentioning

confidence: 99%

Interlaboratory comparison of the TransFix®/EDTA Vacuum Blood Collection tube with the 5 mL Cyto‐Chex® BCT

Harrison¹,

Ward

Bastow

et al. 2018

Cytometry Part B Clinical

View full text Add to dashboard Cite

Background: An interlaboratory study was performed to compare the performance of the 3 mL TransFix ® / EDTA Vacuum Blood Collection Tube (TVT), with the 5 mL Cyto-Chex ® BCT tube (BCT). Both devices are intended for collection and storage of whole blood specimens for immunophenotyping of leukocytes by flow cytometry for up to 14 days.Methods: One site in the United States and two in the United Kingdom tested samples from 10 HIV positive patients and four healthy subjects for a total of 42 samples. From each subject, three blood samples were collected: a BD 4 mL K 3 EDTA Vacutainer (Vacutainer), a TVT, and a BCT. At all sites, samples were analyzed on a BD FACS Canto II flow cytometer for a full lymphocyte subset count within 6 h of collection (all devices) and on Day 11 and Day 15 (TVT and BCT only). Data obtained from the Vacutainer were used as the control data set with which TVT and BCT data were statistically compared.Results and Conclusions: Statistical concordance was demonstrated for both devices in relation to cell absolute count recovery. For cell marker signal, both devices exhibited a significant decrease in mean fluorescence intensity (MFI) for the detection of lymphocyte subsets and their target markers. There was a marked increase in autofluorescence observed for BCT stabilized lymphocytes whereas values for the TVTs were comparable to the control. There were eight instances of statistical equivalence between the level of antibody autofluorescence observed in the control tube and the TVT across both patient cohorts, versus two for the BCT.

show abstract

Section: Introductionmentioning

confidence: 99%

Interlaboratory comparison of the TransFix®/EDTA Vacuum Blood Collection tube with the 5 mL Cyto‐Chex® BCT

Harrison¹,

Ward

Bastow

et al. 2018

Cytometry Part B Clinical

View full text Add to dashboard Cite

show abstract

“…Since our report and many of these case series, several characteristics of PLWH and therapies for PLWH have changed. First, antiretroviral therapies have changed notably with the introduction of the HIV strand transfer integrase inhibitors [20]. High rates of virological suppression are observed with integrase inhibitor-containing antiretroviral regimens and the majority of case series reporting rates of cerebrospinal fluid HIV RNA escape have not included substantial numbers of subjects receiving this class of drug.…”

Section: Introductionmentioning

confidence: 99%

Cerebrospinal fluid HIV RNA in persons living with HIV

et al. 2018

View full text Add to dashboard Cite

show abstract

“…The combination of efavirenz, tenofovir and emtricitabine is no longer a recommended first regimen in many developed countries . However, it is widely used and those successfully treated with it are likely to remain on it.…”

Section: Discussionmentioning

confidence: 99%

“…Using these results, we predict that 77, 60 and 48 patients would need to be exposed to a one-pill regimen rather than a three-pill regimen for 1, 2 and 3 years, respectively, in order to avoid one additional AIDS event or death. The combination of efavirenz, tenofovir and emtricitabine is no longer a recommended first regimen in many developed countries [4,5,27]. However, it is widely used and those successfully treated with it are likely to remain on it.…”

Section: Discussionmentioning

confidence: 99%

Antiretroviral pill count and clinical outcomes in treatment‐naïve patients with HIV infection

et al. 2017

View full text Add to dashboard Cite

show abstract

British HIV Association guidelines for the treatment of HIV‐1‐positive adults with antiretroviral therapy 2015

Cited by 91 publications

References 625 publications

Interlaboratory comparison of the TransFix®/EDTA Vacuum Blood Collection tube with the 5 mL Cyto‐Chex® BCT

Interlaboratory comparison of the TransFix®/EDTA Vacuum Blood Collection tube with the 5 mL Cyto‐Chex® BCT

Cerebrospinal fluid HIV RNA in persons living with HIV

Antiretroviral pill count and clinical outcomes in treatment‐naïve patients with HIV infection

Contact Info

Product

Resources

About